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Composite anaesthetic

A compound anesthesia and drug technology, applied in the direction of anesthetics, drug combinations, hydroxyl compound active ingredients, etc., can solve the problems of large side effects, large dosage, etc., achieve the effect of reducing discomfort and broad application prospects

Inactive Publication Date: 2013-08-28
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of large dosage and side effects of existing anesthetic drugs, the present invention provides a compound anesthetic drug with small dosage, small side effects and good anesthesia effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1, the combined use situation of antioxidant vitamin C and anesthetic propofol

[0050] 1. Experimental animals

[0051] Clean grade C57BL / 6J, male, 6-7 weeks old, weighing 20±2g, purchased from Beijing Weitong Lihua Experimental Animal Company; room temperature 23±2°C, fluorescent lighting 7:00-19:00. Before the official start of the experiment, the mice were allowed to adapt to the laboratory environment for at least 1 week, free to eat and drink, and the experiment was carried out at a fixed time every day (14:00-16:00), and the laboratory environment was kept quiet.

[0052] 2. Drug use

[0053] Propofol (Propofol) injection (specification: 10mg / mL), vitamin C (Vc) injection, 0.9% normal saline injection.

[0054] The anesthetic drug propofol is a new type of rapid and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, and sedation of critically ill patients in the ICU. It has the advant...

Embodiment 2

[0071] Embodiment 2, the combined use situation of antioxidant reduced glutathione (GSH) and anesthetic propofol

[0072] 1. Experimental animals

[0073] Clean grade C57BL / 6J, male, 6-7 weeks old, weighing 20±2g, purchased from Beijing Weitong Lihua Experimental Animal Company; room temperature 23±2°C, fluorescent lighting 7:00-19:00. Before the official start of the experiment, the mice were allowed to adapt to the laboratory environment for at least 1 week, free to eat and drink, and the experiment was carried out at a fixed time every day (14:00-16:00), and the laboratory environment was kept quiet.

[0074] 2. Drug use

[0075] Propofol (Propofol) injection (specification: 10mg / mL), reduced glutathione (GSH), 0.9% normal saline injection; the dose of GSH is 200mg / kg (according to the injection dose commonly used in clinic 2g / d Conversion), 100mg / kg.

[0076] 3. Method

[0077] A general anesthesia induction model of propofol was established in mice, and all drugs were...

Embodiment 3

[0086] Embodiment 3, the combined use situation of antioxidant N-acetylcysteine ​​(NAC) and anesthetic propofol

[0087] 1. Experimental animals

[0088] Clean grade C57BL / 6J, male, 6-7 weeks old, weighing 20±2g, purchased from Beijing Weitong Lihua Experimental Animal Company; room temperature 23±2℃, fluorescent lighting 7:00-19:00, the experiment officially started Before that, the mice were allowed to adapt to the laboratory environment for at least 1 week, free to eat and drink, conduct experiments at a fixed time every day (14:00-16:00), and keep the laboratory environment quiet.

[0089] 2. Drug use

[0090] Propofol (Propofol) injection (specification: 10mg / mL, AstraZeneca), N-acetylcysteine ​​(NAC), 0.9% normal saline injection; NAC dose 200mg / kg (according to clinically commonly used The injection dose is 2g / d conversion, defined as "maximum effective dose"), 100mg / kg.

[0091] 3. Method

[0092] A general anesthesia induction model of propofol was established in ...

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Abstract

The invention discloses a novel clinical composite anaesthetic. The anaesthetic is an injection or powder using an anti-oxidant and a conventional clinical anaesthetic as active components. According to the invention, combined usage of the anti-oxidant and the conventional clinical anaesthetic can substantially decrease a desired clinical dosage during individual usage of the conventional clinical anaesthetic without influencing anesthetic effects, so side effects of the anaesthetic, especially damage of the anaesthetic to important internal organs like the brain, the heart and the kidney, are reduced, the problems of a great usage amount and great side effects of the conventional clinical anaesthetic are overcome, discomfort of a patient in the process of treatment can be substantially reduced, and the risk of cognitive disorder of the patient caused by usage of a great amount of the anaesthetic is lowered down. The composite anaesthetic provided by the invention has the advantages of a small usage amount, safety and high efficiency and is applicable to clinical anesthesia induction and (or) maintenance of medication related to anesthesia induction of an operation and anaesthesia in an operation.

Description

technical field [0001] The invention belongs to anesthetics in the field of medicine, in particular to a compound anesthetic containing antioxidants and a preparation method thereof. Background technique [0002] With the introduction of the concept of "fast track" for surgical anesthesia, it is objectively required clinically that anesthesia should have the least stress response to the body, the least physiological interference, and fast postoperative recovery. Especially with the trend of population aging in our country, there are more and more elderly and critical surgical patients. At the same time, some people think that anesthesia drugs for infants, teenagers and the elderly will have adverse effects on cognition. Therefore, the safety of anesthesia drug application It has also become one of the focuses of people's attention. [0003] Anesthesia drugs are necessary drugs for clinical operations. For example, after more than ten years of development, propofol has been ...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/4174A61K31/135A61K31/515A61K47/24A61K47/22A61P23/00
Inventor 张成岗李伟光仇焕容李军怀李志慧
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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