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A kind of preparation method of bacterial cellulose slow-release dressing

A bacterial cellulose, sustained-release technology, applied in textiles, papermaking, non-woven fabrics, etc., can solve the problems of low dressing efficiency and skin irritation, and achieve the effect of improving effective utilization, reducing side effects and reducing sensitivity

Active Publication Date: 2016-02-10
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional dressings have low drug delivery efficiency, require frequent dressing changes, and are irritating to the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Dissolving chitosan in 0.1% acetic acid aqueous solution by weight, and preparing chitosan acetic acid aqueous solution (oil phase solution) with 0.1% chitosan by weight at room temperature, and mixing gelatin aqueous solution with camptothecin Mix to make an aqueous solution. Wherein the gelatin accounts for 1% by weight of the aqueous phase solution. The two solutions were mixed and mechanically stirred to obtain a uniform water-in-oil (W / O) electrospinning emulsion. The aqueous phase solution accounted for 40% of the volume fraction of the final electrospinning emulsion.

[0021] (2) The electrospinning method is adopted, the electrospinning voltage is set to 1kV, the distance between the spinneret and the bacterial cellulose membrane is 5.0cm, and the spinning speed is 3.0ml / h. The electrospinning emulsion is injected from the spinneret, and the injected emulsion is sprayed onto the bacterial cellulose membrane containing 90% by weight of absolute ethanol. Aft...

Embodiment 2

[0023] (1) Dissolve polyglycolide in hexafluoroisopropanol, prepare a 5% polyglycolide solution (oil phase solution) by weight at 37°C, mix polyvinylpyrrolidone aqueous solution with functional drug ibuprofen Mix to make an aqueous solution. Wherein the polyvinylpyrrolidone accounts for 5% by weight of the aqueous phase solution. The two solutions were mixed and homogenized to obtain a uniform water-in-oil (W / O) electrospinning emulsion. The volume fraction of the aqueous phase solution in the final electrospinning emulsion was 1%.

[0024] (2) The electrospinning method is adopted, the electrospinning voltage is set to 50kV, the distance between the spinneret and the bacterial cellulose membrane is 10.0cm, and the spinning speed is 2.5ml / h. The electrospinning emulsion is ejected from the spinneret, and the injected emulsion is sprayed onto the bacterial cellulose membrane containing 75% by weight of absolute ethanol. After post-treatment, the diameter of 300nm is obtained,...

Embodiment 3

[0026] (1) Dissolve polylactic acid in chloroform, prepare a polylactic acid solution (oil phase solution) with a weight percentage of 1% at room temperature, and mix polyvinyl alcohol aqueous solution with functional drug penicillin to prepare an aqueous phase solution. Wherein the polyvinyl alcohol accounts for 0.1% by weight of the aqueous phase solution. The two solutions were mixed and subjected to ultrasonic treatment to obtain a uniform water-in-oil (W / O) electrospinning emulsion. The aqueous phase solution accounted for 10% by volume of the final electrospinning emulsion.

[0027] (2) The electrospinning method is adopted, the electrospinning voltage is set to 100kV, the distance between the spinneret and the bacterial cellulose membrane is 15cm, and the spinning speed is 2.0ml / h. The electrospinning emulsion is ejected from the spinneret, and the injected emulsion is sprayed onto the bacterial cellulose membrane with a water content of 60% by weight. After post-treat...

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Abstract

The invention discloses a method for manufacturing bacterial cellulose slow-release dressing, and relates to the technical field of medical equipment and manufacture thereof. The method is characterized in that polymers are dissolved in an organic solvent to manufacture oil-phase solution, and water-soluble polymers are mixed with functional drugs to manufacture water-phase solution; the oil-phase solution and the water-phase solution are mixed with each other to obtain uniform water-in-oil (W / O) electrostatic spinning emulsion; and the electrostatic spinning emulsion is ejected from a spinneret by an electrostatic spinning process, ejected emulsion trickles are sprayed onto a bacterial cellulose diaphragm containing anhydrous ethanol and / or water, the bacterial cellulose slow-release dressing is obtained after the bacterial cellulose diaphragm is treated, polymeric nano-fibers with drug slow-release functions uniformly cover surfaces of bacterial celluloses of the bacterial cellulose slow-release dressing to form a network, and diameters of the polymeric nano-fibers range from 100nm to 1000nm. The method has the advantages that a manufacturing procedure is simple and feasible, operation is convenient, and the cost is low; and multiple types of slow-release dressing which carries drugs with different functions can be manufactured by the method as needed, and the slow-release dressing can be used for curing various skin wounds.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a preparation method of a bacterial cellulose slow-release dressing. Background technique [0002] Traditional dressings have low drug delivery efficiency, require frequent dressing changes, and are irritating to the skin. In order to improve the efficacy of drugs, reduce adverse reactions and the number of administrations, and meet the requirements of high efficiency, long-term effect, and low toxic and side effects, drug sustained-release dressings can be used. Sustained drug release is the combination (or compounding, encapsulation) of drug active molecules with polymer carriers, and then administered into the biologically active body through diffusion, penetration and other control methods, and then the drug active molecules are released at an appropriate concentration and duration. So as to achieve the purpose of giving full play to the curativ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H13/00D04H1/728
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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