Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing

Abstract

The invention discloses a preparation method of a bacterial cellulose composite chitosan moist antimicrobial dressing, and relates to medical equipment and the technical field of a preparation of the medical equipment. The preparation method comprises the following steps that a seed mash prepared from activating a strain is dropped on a non-woven fabric or a woven fabric, and a small amount of fermentation culture media are added to be cultured for 12 to 48 hours, then the fermentation culture media are supplemented, and culturing is carried out for 3 to 6 days, and a fermentation product is taken out, the fermentation product is purified to obtain a bacterial cellulose composite non-woven fabric or a woven fabric membrane material, and an electrostatic spinning method is used for ejecting a chitosan solution from a spinneret, trickles of the ejected chitosan solution are ejected to the bacterial cellulose composite non-woven fabric or the woven fabric membrane material containing anhydrous ethanol and / or water, finally the bacterial cellulose composite chitosan moist antimicrobial dressing is obtained after the bacterial cellulose composite non-woven fabric or the woven fabric membrane material containing anhydrous ethanol and / or water is treated. The preparation method disclosed by the invention is simple and easy in preparation processes, convenient to operate, and low in cost, and the prepared moist antimicrobial dressing can cure chronic unhealed traumas, pressure acute refractory wounds, burns, and a large area of soft tissue defects and / or infections.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a method for preparing a bacterial cellulose composite chitosan moist antibacterial dressing. Background technique [0002] Modern medical theory proves that the wound healing process is a continuous dynamic process, which is a process of interaction between cells and cells, cells and cell matrix, and soluble media. From the perspective of the development of medical dressings, with the popularization of "wet therapy" theory and practice, wet dressings have received increasing attention in the world's medical and health fields. The application of "wet therapy" will keep the wound in a warm and humid environment. In this environment, bacteria multiply rapidly in the wound, making the wound an important source of cross-infection in the ward. In order to control the bacteria on the wound and prevent their spread, it is necessary to add antibacterial sub...

AI Technical Summary

Problems solved by technology

Existing composite methods often destroy the three-dimensional nano-network structure of bacterial cellulose itself, resulting in the degradation of some properties of the composite material due to the destruction of the bacterial cellulose structure, such as: mechanical strength, water absorption performance, air permeability, etc.

The destruction of these properties will limit the application of bacterial cellulose materials in the field of dressings