Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tio2 nanotube drug sustained release material with pha coating and its application

A slow-release material and nanotube technology, applied in medical science, surgery, coating, etc., can solve the problems of uncontrollable drug release rate, too fast release rate, difficult to control, etc., and achieve good biodegradability and prolonged release Effect of time, good biocompatibility

Active Publication Date: 2015-10-14
SHANGHAI JIAOTONG UNIV +1
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the uncontrollable drug release rate of this method, and the shortcomings of the release rate too fast, it was proposed to use TiO 2 A solution for surface modification of nanotubes【Song Y Y, Schmidt-Stein F, Bauer S, et al.Amphiphilic TiO 2 nanotube arrays: an actively controllable drug delivery system [J]. Journal of the American Chemical Society, 2009, 131(12): 4230-4232.], but this method has complicated steps, is difficult to control, and requires Perform different surface modifications

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) TiO 2 Preparation of Nanotubes: Preparation of TiO by Anodic Oxidation 2 Nanotube, the length of the nanotube is 0.8-2.5μm, the inner diameter of the tube is 70-140nm, and the wall thickness of the tube is 20-40nm.

[0037] (2) Pretreatment of samples before drug loading: for TiO 2 Heat treatment of nanotubes: in a vacuum muffle furnace from room temperature to 400°C at a rate of 1°C / min, keep warm for 4h, and then cool down with the furnace. Alkali treatment is performed on the heat-treated sample, and the sample is immersed in a 2.0M NaOH solution for 2 hours to form sodium titanate on its surface.

[0038] (3) Loading of gentamicin: immerse the heat-treated and alkali-treated sample in the mixed solution of gentamicin and simulated body fluid (SBF), and incubate for 48h in a cell culture device to obtain loaded gentamicin nanotube.

[0039](4) Prepare PHA polymer film at the mouth of the nanotube: 2g of P3,4HB is dissolved in 2ml of chloroform solution, and t...

Embodiment 2

[0041] (1) TiO 2 Preparation of Nanotubes: Preparation of TiO by Hydrothermal Synthesis 2 The nanotube, the nanotube tube length is 0.5-2 μm, the tube diameter is 30-50 nm, and the tube wall thickness is 5-10 nm.

[0042] (2) Pretreatment of samples before drug loading: for TiO 2 Heat treatment of the nanotubes: in a vacuum muffle furnace from room temperature to 500°C at a rate of 3°C / min, hold for 3h, and then cool down with the furnace. The heat-treated sample is subjected to alkali treatment, and the sample is immersed in a 5.0M NaOH solution for 1 hour to form sodium titanate on its surface.

[0043] (3) Loading of vancomycin: soak the heat-treated and alkali-treated samples into a mixture of vancomycin and simulated body fluid (SBF), and incubate in a cell culture device for 24 hours to obtain vancomycin-loaded nanotubes.

[0044] (4) Preparation of PLGA polymer film on the surface of nanotubes: 1 g of PLGA was dissolved in 3 ml of chloroform solution, and then TiO2 l...

Embodiment 3

[0046] (1) TiO 2 Preparation of Nanotubes: Preparation of TiO by Anodic Oxidation 2 Nanotube, the length of the nanotube is 0.8-2.5μm, the inner diameter of the tube is 70-140nm, and the wall thickness of the tube is 20-40nm.

[0047] (2) Pretreatment of samples before drug loading: for TiO 2 Heat treatment of nanotubes: heating from room temperature to 600°C in a vacuum muffle furnace at a rate of 5°C / min, keeping the heat for 2 hours, and then cooling down with the furnace. Alkali treatment is performed on the heat-treated sample, and the sample is immersed in 8.0M NaOH solution for 0.5h to form sodium titanate on its surface.

[0048] (3) Loading of gentamicin: immerse the heat-treated and alkali-treated sample in the mixed solution of gentamicin and simulated body fluid (SBF), and incubate for 72h in a cell culture device to obtain loaded gentamicin nanotube.

[0049] (4) Preparation of PHA polymer film at the nanotube mouth: 1g of P3HB was dissolved in 2ml of chlorofo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
verticalityaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a TiO2 nano-tube drug sustained-release material with a PHA (phytohematoagglutinin) coating and application thereof. The drug sustained-release material is a TiO2 nano-tube of which a polyhydroxyalkanoate polymeric membrane is coated on the outer surface, and can be used for drug loading. Compared with the prior art, the PHA polymeric membrane is coated on the surface of the drug-loaded TiO2 nano-tube, so that the speed of a drug release process can be controlled, and the drug release time can be prolonged; and the method has the advantages of simple process, reliable effect, safe process and low cost.

Description

technical field [0001] The invention belongs to the technical field of surface treatment of orthopedic implant materials, in particular to a TiO with PHA coating 2 Nanotube drug sustained release material and its application. Background technique [0002] Titanium and titanium alloys are widely used in the field of orthopedic implants due to their high mechanical strength, biological inertness, good biocompatibility and elastic modulus close to that of human bone. However, one of the most serious complications after artificial joint implantation is postoperative infection. The fundamental reason why infection is difficult to cure is the formation of biofilm on the surface of the prosthesis and the lack of immunity at the prosthesis / tissue interface, which is conducive to bacteria (mainly epidermal grapevine). cocci) colonize the prosthesis. [0003] In order to prevent implant infection, most researchers load antibacterial coatings on the surface of implants. For example, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/16
Inventor 李华王珮严怡峰刘忠堂刘河洲陶文燕
Owner SHANGHAI JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com