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Traditional Chinese medicinal recipe for inhibiting aeromonas sobria

The technology of Chinese herbal medicines and monospores is applied in the directions of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc., which can solve the problems of deterioration of the breeding environment, imbalance of ecological balance, threats to consumers, etc., and achieves a simple production process, No drug resistance, inexpensive effect

Inactive Publication Date: 2013-05-22
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term abuse of drugs or antibiotics will cause water environment pollution, which will lead to deterioration of the breeding environment, imbalance of ecological balance, and bacteria will develop drug resistance, and drug residues will pose a potential threat to consumers

Method used

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  • Traditional Chinese medicinal recipe for inhibiting aeromonas sobria
  • Traditional Chinese medicinal recipe for inhibiting aeromonas sobria
  • Traditional Chinese medicinal recipe for inhibiting aeromonas sobria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The invention relates to a Chinese herbal medicine formula for inhibiting Aeromonas sobria. The following 43 kinds of Chinese herbal medicines all have different degrees of antibacterial effects on Aeromonas sobria.

[0011] First of all, catechu and Chinese gallbladder had the strongest antibacterial effect on Aeromonas sobria, and their MICs were both 6.25 mg / ml; Schisandra, ebony and pomegranate peel also had strong inhibitory effects on Aeromonas sobria, and their MICs were 6.25 mg / ml. Both are 12.5mg / ml. Secondly, Kufen, Diding, Clematis, Burnet, Clove and Coptis have strong inhibitory effects on Aeromonas temperatus, and their MICs are all 25mg / ml. Thirdly, crane lice, rare sage grass, mugwort leaves, perilla seeds, dijincao, knotweed, leaked reed seeds, cassia seeds, prunella vulgaris, isatidis, angelica dahurica, goose does not eat, white peony root, sunburned myrrh, magnolia bark, asters, snake Bedbug, wild chrysanthemum, rhubarb, forsythia, hedyotis, raspberr...

Embodiment 2

[0015] The invention relates to a Chinese herbal medicine formula for inhibiting Aeromonas sobria. The Chinese herbal medicine is composed of the following raw materials and weight ratios: catechu, gallnut, schisandra and ebony are mixed in a ratio of 2:4:1:2. The results showed that the formula has a significant antibacterial effect on Aeromonas temperatus, which is more obvious than the antibacterial effect of single herbal medicine and other combinations of Chinese herbal medicine compound formula, and its minimum inhibitory concentration MIC is 2.93mg / ml.

[0016] The minimum inhibitory concentration MIC of the compound formula of Chinese herbal medicine in the ratio of 1:1:1:1 was 12.5 mg / ml, and the ratio of catechu, gall, Schisandra, and ebony was 2:2:1: The minimum inhibitory concentration MIC of the compound formula of Chinese herbal medicine mixed in the ratio of 8 is 20.31 mg / ml, which is not as good as the antibacterial effect of the best formula.

Embodiment 3

[0018] Antibacterial test of Chinese herbal medicine against Aeromonas temperatus in vitro

[0019] 1. Selection of Chinese herbal medicine and preparation of liquid medicine

[0020] The 86 kinds of Chinese herbal medicines selected in this study were all purchased from Beijing Tongrentang Pharmacy in Ningbo City. The 86 kinds of Chinese herbal medicines are: Burnet, pomegranate peel, dry alum, Kochia scoparia, crane lice, sage grass, lobelia, mugwort leaves, perilla, andrographis, dijincao, Guanzhong, knotweed slices, snakeberry grass , Shijunzi, leaking reed seeds, cassia seeds, flavescens slices, cork, gonggong leaves, Senecio, dandelion, sage, perilla stalk, artemisia annua, Viola chinensis, perrin, wormwood, prunella, calamus, isatis root , Torreya, (raw) Shouwu, Angelica dahurica, Ginkgo, Laifuzi, Myrobalan meat, Suzi, Clematis, Curcuma, Goose Bushi, Baishao, Baibu, Sunburned Myrrh, Solanum nigrum, Magnolia officinalis, Aster, Catechin, Araceae, Galla, Astragalus, Cni...

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Abstract

The invention discloses a traditional Chinese medicinal recipe for inhibiting aeromonas sobria. The recipe is characterized by comprising at least one of catechu, galla chinensis, fructus schisandrae chinensis, fructus mume, pericarpium granati, aluminis usti, corydalis bungeana turcz, radix clematidis, radix sanguisorbae, flos caryophyllata, coptis chinensis franch, fructus carpesii, siegesbeckia orientalis L, folium artemisiae argyi, fructus perillae, herba euphorbiae humifusae, rhizoma polygoni cuspidate, radix rhapontici, semen cassiae, spica prunellae, radix isatidis, radix angelicae dahuricae, herba centipedae, white paeony root, fried myrrha, cortex magnoliae officinalis, radix asteris, fructus cnidii, wild chrysanthemum, radix et rhizoma rhei, fructus forsythiae, hedyotis diffusa, fructus rubi, anemone chinensis, semen arecae, tetradium ruticarpum, gentiana scabra bunge, chaenomeles speciosa, raw rhizoma atractylodis, folium isatidis, houttuynia cordata, cortex moutan radicis and sapium sebiferum, wherein a recipe which is formed by mixing the catechu, the galla chinensis, the schisandrae chinensis and the fructus mume according to the mass ratio of 2:4:1:2 has an optimal antibacterial effect. The recipe has the advantages of naturality, no toxity and residues, no tolerance and low price.

Description

technical field [0001] The invention relates to a Chinese herbal medicine formula, in particular to a Chinese herbal medicine formula for inhibiting Aeromonas sobria. Background technique [0002] As another common pathogenic species of Aeromonas, Aeromonas sobria is widely distributed in various fresh waters and is one of the main pathogenic pathogens of aquatic organisms. It can harm almost all freshwater fishes, frogs, soft-shelled turtles and even birds and mammals, causing diseases such as sepsis and diarrhea as the main symptoms. Aeromonas sobria has a strong pathogenicity to fish, and can invade healthy fish, causing the internal organs of the fish to bleed and die quickly. Aeromonas sobria can also cause skin ulceration of carp. Aeromonas sobria is one of the most common pathogenic bacteria in aquaculture freshwater fish in my country, and it is also one of the most common pathogenic bacteria among people in coastal areas of my country. Because Aeromonas sobria can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K36/86A61K36/78A61K36/754A61K36/748A61K36/739A61K36/736A61K36/732A61K36/73A61K36/718A61K36/716A61K36/71A61K36/708A61K36/704A61K36/634A61K36/61A61K36/575A61K36/57A61K36/536A61K36/482A61K36/47A61K36/328A61K36/28A61K36/234A61K35/64A61K33/06A61P31/04
Inventor 龚一富张文青章丽潘益芳李君王何瑜童丽娟
Owner NINGBO UNIV
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