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Green coffee bean extract sustained-release tablet and preparation method thereof

A green coffee bean and extract technology, applied in the field of green coffee bean extract sustained-release tablets, can solve problems such as user discomfort and adverse reactions, increase weight loss and fat-lowering effects, eliminate discomfort, improve weight loss and lipid-lowering Effect

Inactive Publication Date: 2013-05-15
ANJI E SWEET CANDY FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the disadvantages of using green coffee bean extracts in the prior art, which may cause discomfort and adverse reactions to users, and provides a new type of green coffee that can alleviate the above discomfort and adverse reactions and has a synergistic weight loss effect. Coffee bean extract sustained-release tablet and preparation method thereof

Method used

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  • Green coffee bean extract sustained-release tablet and preparation method thereof
  • Green coffee bean extract sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Pre-mix 20%wt green coffee bean extract (containing 50% chlorogenic acid), 10%wt HPMC (E50), 0.2%wt precrossed starch, and use GHL high-speed mixing granulator for mixing Granulate, shear at medium / high speed, stir at medium / low speed, mix evenly and break up agglomerates; use 80% alcohol solution to spray the mixture of green coffee bean extract, HPMC and precrossified starch Granules, the spraying time is about 15 minutes, the amount of alcohol solution used is 15-50%wt of the component formula, after adding the alcohol solution, the mixture is wet mixed (shear at high speed, stir at medium / low speed) 1 -2 minutes to obtain granules; pulverize the obtained granules, break up larger agglomerates, and pass through a swing granulator to obtain smaller granules. The granules are dried with a fluidized bed dryer or an oven, and the drying loss is 3%-9%; the granules are pulverized and sieved with a 12-20 mesh to obtain the required particle size. Continue to add 0.2%wt of...

Embodiment 2

[0022] Steps as described in Example 1, wherein the content of each component is respectively: 50%wt green coffee bean extract, 40%wt HPMC, 2.0%wt stearic acid, 4.0%wt stomach-soluble film Coating powder, the balance is lactose. The obtained tablet is 1000 mg / tablet, and each tablet contains 500 mg of green coffee extract.

Embodiment 3

[0024] Steps as described in Example 1, wherein the contents of each component are respectively: 30%wt of green coffee bean extract, 20%wt of HPMC, 46%wt of sugar alcohol, 3%wt of gastric-soluble film package The magnesium stearate of coating powder, 1%wt. The obtained tablet is 1000 mg / tablet, and each tablet contains 300 mg of green coffee extract.

[0025] Comparative test 1

[0026] Take the green coffee bean extract sustained-release tablets obtained in the above-mentioned Examples 1-3 for a comparative test, and randomly select 48 people (half male and half female, aged between 23-45 years old) as test subjects, with 16 people as a group, a total of 3 groups, a total of 8 people with half of the test subjects in each group took the sustained-release tablets of the above-mentioned embodiments 1-3 respectively as the experimental group, each person took 1 tablet each time, took 3 times in the morning, noon and evening every day, and took it continuously for 6 months , re...

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PUM

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Abstract

The invention relates to the manufacturing field of food and drugs, and discloses a green coffee bean extract sustained-release tablet. The green coffee bean extract sustained-release tablet comprises the following components: 20%-50%wt of green coffee bean extract, 10%-40%wt of hydroxy propyl methyl cellulose (HPMC), 0.2%-4.0%wt of lubricating agent, 2.0%-4.0%wt of stomach-soluble film coating powder and the balance of excipient. The invention further discloses a preparation method of the sustained-release tablet. The green coffee bean extract sustained-release tablet has the advantages of better weight loss effect, slight uncomfortableness after orally taking and high application value.

Description

technical field [0001] The invention relates to the field of food and drug manufacture, in particular to a sustained-release tablet of green coffee bean extract and a preparation method of the sustained-release tablet. Background technique [0002] Chlorogenic acid has a wide range of antibacterial effects, but it can be inactivated by proteins in the body. Similar to caffeic acid, when taken orally or intraperitoneally, it can increase the excitability of the central nervous system, increase the peristalsis of the gastrointestinal tract, especially the small intestine, and increase the secretion of bile. At present, chlorogenic acid has many applications in weight loss and lipid lowering. Green coffee bean extract contains more chlorogenic acid, so it is often used as an effective source of chlorogenic acid. Therefore, green coffee bean extract is widely used in the field of weight loss and fat reduction . Existing studies have pointed out that direct consumption of gree...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/28A61K47/38A61P3/04A61P3/06
Inventor 金杰
Owner ANJI E SWEET CANDY FOOD
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