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Tilmicosin dry suspension, method for preparing dry suspension and uses thereof

A technology of tilmicosin and dry suspension, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of preparing dry suspensions without micosin To achieve the effect of facilitating clinical drinking water administration, expanding the scope of application, and improving palatability

Active Publication Date: 2014-09-24
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no relevant report that tilmicosin is prepared into a dry suspension

Method used

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  • Tilmicosin dry suspension, method for preparing dry suspension and uses thereof
  • Tilmicosin dry suspension, method for preparing dry suspension and uses thereof
  • Tilmicosin dry suspension, method for preparing dry suspension and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 tilmicosin dry suspension of the present invention

[0023] prescription:

[0024] Table 1 Prescription Ⅰ of tilmicosin dry suspension

[0025] name

Quantity / kg

Tilmicosin

5.75

Ethyl cellulose

25

powdered sugar

64

Poloxamer 188

2.5

Sodium carboxymethyl cellulose

1.25

sodium saccharin

0.5

Anhydrous Sodium Citrate

1

total

100

[0026] Process: 1. Take white granulated sugar, crush it, pass through an 80-mesh sieve, and weigh the prescription amount for later use;

[0027] 2. Take anhydrous sodium citrate and sodium saccharin according to the prescription and mix them by hand, then add sodium carboxymethylcellulose and poloxamer 188 and mix them by hand, then add tilmicosin and ethyl cellulose and mix them evenly. Pulverize and pass through a 200-mesh sieve for subsequent use;

[0028] 3. Put the powder obtained in the above two s...

Embodiment 2

[0029] Embodiment 2 The preparation of tilmicosin dry suspension of the present invention

[0030] prescription:

[0031] Table 2 Tilmicosin dry suspension prescription Ⅱ

[0032] name

Quantity / kg

Tilmicosin

10

Ethyl cellulose

15

powdered sugar

66.8

Poloxamer 188

2.5

Sodium carboxymethyl cellulose

2.5

Fresh Milk Flavor

0.6

sodium saccharin

0.6

Anhydrous Sodium Citrate

2

total

100

[0033] Process: 1. Take white granulated sugar, crush it, pass through an 80-mesh sieve, and weigh the prescription amount for later use;

[0034] 2. Take anhydrous sodium citrate and sodium saccharin according to the prescription and mix them by hand, then add sodium carboxymethylcellulose and poloxamer 188 and mix them by hand, then add tilmicosin and ethyl cellulose and mix them evenly. Pulverize and pass through a 200-mesh sieve for subsequent use;

[0035] 3. Put the powde...

Embodiment 3

[0036] Embodiment 3 The preparation of tilmicosin dry suspension of the present invention

[0037] prescription:

[0038] Table 3 Tilmicosin dry suspension prescription III

[0039] name

Quantity / kg

Tilmicosin

14

Ethyl cellulose

10

powdered sugar

59.4

Poloxamer 188

3

Sodium carboxymethyl cellulose

6

Fresh Milk Flavor

0.8

sodium saccharin

0.8

Anhydrous Sodium Citrate

6

[0040] Process: 1. Take white granulated sugar, crush it, pass through an 80-mesh sieve, and weigh the prescription amount for later use;

[0041] 2. Take anhydrous sodium citrate and sodium saccharin according to the prescription and mix them by hand, then add sodium carboxymethylcellulose and poloxamer 188 and mix them by hand, then add tilmicosin and ethyl cellulose and mix them evenly. Pulverize and pass through a 200-mesh sieve for subsequent use;

[0042] 3. Put the powder obtained in the above...

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Abstract

The present invention provides a tilmicosin dry suspension. The invention also provides a method for preparing the dry suspension and uses thereof. According to the tilmicosin dry suspension of the present invention, via reasonable compatibility of excipients, dispersion of tilmicosin in water is significantly improved, so the tilmicosin is enabled to be evenly distributed in the water in a long time, convenient for clinical administration of medicine by drinking water. Meanwhile, the dry suspension has greatly improved the palatability of the tilmicosin, so the dry suspension can be used not only for animal groups with underdeveloped taste such as chickens, but also for other animal groups with sensitive taste such as pigs, thus expanding the scope of application of the product.

Description

technical field [0001] The invention relates to a tilmicosin dry suspension, a preparation method and application thereof. Background technique [0002] Tilmicosin (Tilmicosin) is a semi-synthetic macrolide antibiotic for livestock and poultry, with a chemical name of 4 A -O-de(2,6-dideoxy-3-C-methyl-L-ribose-pyranylhexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)- Tylosin, also known as 20-deoxy-20-(3,5-dimethyl-1-piperidinyl) decarbamucose tylosin, its structural formula is: [0003] [0004] Molecular formula is C 46 h 80 N 2 o 13 , molecular weight 869.13. [0005] The tilmicosin products recorded in "The Veterinary Pharmacopoeia of the People's Republic of China (2010 Edition)" have three dosage forms: premix, injection, and solution, and are mainly used clinically to treat animals such as cattle, goats, sheep, dairy cows, pigs, and chickens. Infectious diseases caused by sensitive bacteria, especially livestock and poultry respiratory infection and cow mastiti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/706A61K47/38A61K47/40A61K47/36A61P31/04
Inventor 丁晓刚房春林李犹平杨海涵吴学渊李超徐莎
Owner CHENGDU QIANKUN VETERINARY PHARMA
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