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Compound tablet containing tamsulosin (slow-release) and finasteride (quick-release) and preparation method thereof

A kind of technology of finasteride and compound tablet, applied in the field of pharmaceutical preparations

Inactive Publication Date: 2013-04-03
江苏开元医药有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The combination of tamsulosin hydrochloride and finasteride has been reported. According to the research, the combination of the two drugs has achieved a good therapeutic effect on bengin prostatic hyperplasia (BPH) with chronic prostatitis (CP) (see Journal of Zhejiang University of Traditional Chinese Medicine, Volume 35, Issue 2, March 2011, Observation on the curative effect of finasteride combined with tamsulosin in the treatment of benign prostatic hyperplasia with chronic prostatitis), there is no compound preparation of tamsulosin hydrochloride and finasteride listing

Method used

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  • Compound tablet containing tamsulosin (slow-release) and finasteride (quick-release) and preparation method thereof
  • Compound tablet containing tamsulosin (slow-release) and finasteride (quick-release) and preparation method thereof

Examples

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Embodiment Construction

[0027] Set forth the present invention with example below:

[0028] Case 1: Double layer film

[0029] Slow release layer:

[0030] Tamsulosin Hydrochloride 0.2g HPMC15M 50g lactose 10g Sodium stearyl fumarate 0.5g

[0031] Immediate release layer:

[0032] finasteride 5g microcrystalline cellulose 45g Croscarmellose Sodium 15g 2%HPMCK30 aqueous solution Appropriate amount Sodium stearyl fumarate 0.5g

[0033] A total of 1000 pieces were made.

[0034] making process:

[0035] Weigh the prescribed amount of tamsulosin hydrochloride and lactose, mix well, then mix well with HPMC15M, add water to moisten, granulate at 20 mesh, dry at 50-60°C, granulate at 20 mesh, add sodium stearyl fumarate and mix Uniformly, obtain the sustained-release granules containing tamsulosin hydrochloride;

[0036] Weigh finasteride, microcrystalline cellulose and croscarmellose sodium and mix well, add 2% HPMCK30 aqueous...

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Abstract

The invention relates to a compound tablet containing tamsulosin (slow-release) and finasteride (quick-release) and a preparation method of the compound tablet, and belongs to the field of pharmaceutical formulations.

Description

technical field [0001] The invention relates to a compound tablet containing tamsulosin (sustained release) and finasteride (fast release) and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Tamsulosin hydrochloride: [0003] Chemical name: 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride [0004] The chemical structural formula is: [0005] [0006] Molecular formula: C20H28N2O5S HCI [0007] Molecular weight: 444.9. [0008] Tamsulosin hydrochloride is a new type of a1 receptor blocker, which can selectively block the smooth muscle a1 receptors of the bladder neck, prostate gland and capsule, reduce smooth muscle tension, reduce lower urinary tract resistance, and improve the pain caused by prostatic hypertrophy. Urinary disorders. Animal experiments have shown that tamsulosin hydrochloride can selectively block the adrenergic a1 receptors of rats and rabbi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/18A61K9/24A61K9/22A61P13/08
Inventor 燕立波王丽赵晖程思
Owner 江苏开元医药有限公司
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