Tamsulosin sustained release tablet and preparation method thereof

A technology of sustained-release tablets and tamsulosin, which is applied in the field of tamsulosin sustained-release tablets and its preparation, can solve the problems of long production process, lack of preparation methods, complex preparation equipment, etc., and achieve simple equipment and high production process. Convenience, avoiding the effect of gelation process

Active Publication Date: 2009-12-09
KUNMING JIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many methods for preparing sustained-release tablets, a simple and effective preparation method is generally lacking, and the above-mentioned methods often require complicated preparation equipment and a long production process

Method used

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  • Tamsulosin sustained release tablet and preparation method thereof
  • Tamsulosin sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Preparation of extended-release tablets:

[0066] As shown in Table 1, by fixing the dosage of hypromellose inside the prescription, gradually increasing the dosage of external hypromellose, adopt wet granulation and tableting, and observe the change law of the release rate in 2 hours.

[0067] Table 1 plus prescriptions of different amounts of hypromellose

[0068]

[0069]

[0070] The specific operations are as follows:

[0071] 1. As shown in Table 1, weigh various raw materials, wherein hypromellose is The K 100M type hypromellose in the K series hypromellose has a particle size of 120 mesh to 200 mesh.

[0072] 2. The weighed tamsulosin is dissolved in 80% ethanol to obtain solution a for subsequent use;

[0073] 3. Weigh povidone K30, add 80% ethanol to dissolve it, add it to solution a, and mix to obtain solution b;

[0074] 4. Weigh the added hypromellose and talc described in Table 1, add the trough mixer, after stirring and mixing, evenly and slow...

Embodiment 2

[0085] The raw materials and operations taken in this example are basically the same as those in Example 1, and the only difference is that the hypromellose used in this example and the hypromellose used externally are any of the hypromellose in the following table. .

[0086] 1

2

3

4

trademark

No. Model

90SH-100000

90SH-15000

90SH-100000SR

60SH-10000

average

Granularity

70um

70um

50um

70um

Production

Manufacturer

Shin-Etsu Chemical

Industrial Co., Ltd.

(ShinEtsu)

Shin-Etsu Chemical

Industrial Co., Ltd.

(ShinEtsu)

Shin-Etsu Chemical Co., Ltd.

Industry Co., Ltd.

(ShinEtsu)

Shin-Etsu Chemical Co., Ltd.

Industry Co., Ltd.

(ShinEtsu)

[0087] The measured results of the tamsulosin sustained-release tablets prepared by using any one of the above-mentioned 4 kinds of hypromellose are t...

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PUM

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Abstract

The invention provides a Tamsulosin tablet, which is prepared by the following steps: taking Tamsulosin, and dissolving in ethanol; adding a part of hydroxypropyl methyl cellulose and other proper excipients, evenly mixing, and pelletizing; and then adding the rest hydroxypropyl methyl cellulose, fully mixing, and pressing into the sustained release tablet. The release of the Tamsulosin tablet in two hours is effectively controlled within 40 percent, and the sustained release performance of the medicament is greatly improved. The preparation method has simple adopted equipment and concise production process.

Description

technical field [0001] The invention relates to a tamsulosin sustained-release tablet, in particular to a tamsulosin sustained-release tablet prepared by internally adding hypromellose before granulation and adding hypromellose externally after granulation and a preparation method thereof. Background technique [0002] Tamsulosin (Tamsulosin, also translated as Tamsulosin) chemical name is (-)-(R)-5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]propane Base] -2-methoxyphenyl sulfonamide, a selective α1 adrenergic receptor blocker, for voiding disorders caused by benign prostatic hyperplasia (BPH). Tamsulosin described in the present invention includes tamsulosin and pharmaceutically acceptable salts thereof. [0003] There are two main types of sustained-release preparations: matrix type and depot type. Among them, the drug is evenly dispersed in various carrier materials in the form of molecules, microcrystals, and particles, forming a matrix sustained-release preparation. The dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/18A61K47/38A61P13/08
Inventor 曹天海苏礼镜王文
Owner KUNMING JIDA PHARMA
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