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Platycodin D sperm-killing contraceptive suppository for external use and placing device thereof

A platycodon saponin and spermicidal technology, which is applied in the direction of female contraceptives, suppository delivery, other medical devices, etc., can solve problems such as no reports on spermicidal research, and achieve a strong spermicidal effect.

Inactive Publication Date: 2013-04-03
王磊光
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, there is no research report about platycodon saponin D in vitro spermicide

Method used

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  • Platycodin D sperm-killing contraceptive suppository for external use and placing device thereof

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Embodiment Construction

[0016] The present invention will be further described below.

[0017] 1. Preparation of Campanulaceae saponin extract:

[0018] Accurately weigh 50g of bellflower sample powder, place it in a 500mL Erlenmeyer flask, add 300mL of 70% methanol, soak for 24 hours, ultrasonicate for 30 minutes, repeat 4 times, centrifuge, filtrate is recovered under reduced pressure to obtain extract, add 300mL of acetone for precipitation After filtration, the filtrate was recovered to obtain the extract, which was added to 300mL of water, transferred to a separatory funnel, and extracted twice with 300mL of ether. Discard the ether layer, add 300mL of water to the water layer, extract with saturated n-butanol 4 times, combine the n-butanol layers and recover under reduced pressure to obtain the extract, and finally precipitate with 500mL of ether to remove impurities, and dry the precipitate to obtain a white powder substance 280 mg. Accurately weigh 50 mg of white powder, and dissolve it in ...

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Abstract

The invention discloses a platycodin D sperm-killing contraceptive suppository for external use. The contraceptive suppository is characterized in that the active ingredient of the suppository is platycodin D diluent; the platycodin D diluent is different concentrations of physiological saline solution of platycodin D extracts; and the suppository is solid at normal temperature. When the contraceptive suppository is used, the contraceptive suppository is quickly dissolved in vaginas at body temperature, is in a semi-liquid state and can quickly kill sperms after being in contact with the sperms and deactivate the sperms, thus playing a role in contraception. The invention also discloses a matched placing device of the contraceptive suppository. The contraceptive suppository has a good contraceptive effect and can avoid unplanned pregnancy.

Description

technical field [0001] The invention relates to a contraceptive suppository with platycodon saponin as an active ingredient, belonging to the technical field of medicine, in particular to a contraceptive suppository for external use of platycodon saponin D and a placement device. Background technique [0002] Platycodon grandiflorum is the dry root of Campanulaceae plant Campanulaceae. Platycodon grandiflorum is flat in nature, bitter in taste, pungent, and has the effects of resolving phlegm and relieving cough, relieving throat and opening sound, clearing lung qi, draining pus and eliminating carbuncle. In recent years, as a traditional Chinese medicine with the same source of medicine and food, Platycodon grandiflorum has attracted widespread attention for its pharmacological effects in terms of immune regulation, anti-inflammation, expectorant, liver protection, and blood lipid reduction. At present, the more researched monomer compounds are platycodon saponins A, B, C,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/704A61K47/44A61F6/06A61M31/00A61P15/18
Inventor 王磊光邱毅
Owner 王磊光
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