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Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof

A vaginal expansible suppository and hygienic technology, which is applied in suppository delivery, measuring devices, and pharmaceutical formulations, can solve the problems of undisclosed dosage of drug ingredients, disordered expansion, and unsatisfactory effects, so as to avoid secondary infection and prevent outflow Effect

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this patent does not disclose the report that can solve the above-mentioned side effect problem, although it has the effect of treating vaginitis and spermicide at the same time, the effect is still unsatisfactory
In addition, "Chinese Journal of Family Planning" published an article titled "Experimental Research on the In Vitro and External Spermicidal and Anti-fertility Effects of Bosidei Hygienic Suppository" in the 5th issue of 1997, the total number 31, which disclosed a Bosidi sanitary suppository, which is refined from Chinese herbal medicines such as licorice, grass, pinellia, and cnidium, has the effect of treating vaginitis and killing sperm. Although the effect is good, the dosage of each drug ingredient is not disclosed
In addition, the Shuan Sanitary Suppository also has the following technical problems: 1. The traditional Shuan Sanitary Suppository has no expansion effect, or the expansion is disordered, which greatly reduces the clinical application; , the content, stability, and melting time between batches vary greatly

Method used

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  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof
  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof
  • Shu'an sanitary expandable vaginal suppository, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Prescription quantity: 1000 parts by weight of the base and traditional Chinese medicine composition does not conform to the claims

[0107] Composition dosage:

[0108] Liao Diao Bamboo 300g Liangmianzhen 100g Cnidium Seed 100g

[0109] Rhubarb 200g Wild Chrysanthemum 200g Licorice 150g

[0110] Honeysuckle 100g bitter dish 100g

[0111] Substrate dosage:

[0112] Lecithin 10g, coconut oil 150g, palm kernel oil 150g;

[0113] Massa Estarinum A300g

[0114] Dosage of cotton sliver: 1000 pieces, 2g each

[0115] Preparation method of traditional Chinese medicine composition:

[0116] a) Take 50% of Liaodiao bamboo, liangmianzhen and Cnidium cylindrica by adding 6 times the amount of 50 ethanol, and extract for 2 hours for 1 time. Combine the extracts of each time and recover the ethanol to obtain the first alcohol extract;

[0117] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and bitter dish, add 6 times the amount of water, extract for 4 hours, extract twice, combine t...

Embodiment 2

[0123] Prescription: 100 pieces

[0124] Composition dosage:

[0125] Liao Diao bamboo 35g liangmianzhen 15g Cnidium seed 30g

[0126] Rhubarb 30g Wild Chrysanthemum 30g Licorice 20g

[0127] Honeysuckle 30g, bitter dish 30g.

[0128] Substrate dosage:

[0129] Lecithin 5g, coconut oil 70g, palm kernel oil 70g;

[0130] Massa Estarinum AS12g;

[0131] 100 cotton slivers, 1g each

[0132] Preparation method of traditional Chinese medicine composition:

[0133] a) Take 50% of Liaodiao bamboo, liangmianzhen and Cnidium cylindrica by adding 8 times the amount of 75% ethanol, and extract for 4 hours for 3 times. Combine the extracts of each time and recover the ethanol to obtain the first alcohol extract;

[0134] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and bitter dish, add 7 times the amount of water, extract for 5 hours, extract 3 times, combine the extracts to obtain the water extract, and keep the medicine residue;

[0135] c) Take wild chrysanthemum, honeysuckle and medic...

Embodiment 3

[0140] Prescription: 100 pieces

[0141] Composition dosage:

[0142] Liao Diao Bamboo 25g Liangmianzhen 20g Cnidium Seed 15g

[0143] Rhubarb 15g Wild Chrysanthemum 15g Licorice 10g

[0144] Substrate dosage:

[0145] Lecithin 3g, coconut oil 40g, palm kernel oil 40g;

[0146] Massa Estarinum T11g;

[0147] 100 cotton sliver, 3g each

[0148] Preparation method of traditional Chinese medicine composition:

[0149] a) Take 50% of Liaodiao bamboo, liangmianzhen and Cnidium cylindrica by adding 7 times the amount of 65% ethanol, and extract for 3 hours for a total of 2 times. Combine the extracts of each time and recover the ethanol to obtain the first alcohol extract;

[0150] b) Take the other 50% of Liao Diao bamboo, rhubarb, licorice, and bitter dish, add 8 times the amount of water, extract for 6 hours, extract 3 times, combine the extracts to obtain the water extract, and keep the medicine residue;

[0151] Combine the extracts to obtain a water extract and retain the drug residue;

[0152...

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Abstract

The invention relates to a Shu'an sanitary expandable vaginal suppository. The expandable suppository comprises 30-500 weight parts of a traditional Chinese medicine composition, 800-2000 weight parts of a matrix and 500-4000 weight parts of an expansion carrier. The suppository is fully expanded, and the drug-containing layer and the inner wall of the vagina can fully contact to prevent outflow liquid. The expandable vaginal suppository has beneficial effects of high efficacy and low incidence on pruritus vulvae, pain and frequent micturition; and the Shu'an sanitary expandable vaginal suppository employs six originally created leading technologies. Surprisingly, the suppository provided by the invention can the treat various vaginitis and at the same time has strong spermicidal effect.

Description

Technical field [0001] The invention belongs to the field of vaginal suppositories, and particularly relates to a Shuan hygienic vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] The 61st volume of "Standards for New Drug Transformation" discloses a Shuan sanitary suppository with a grain weight of 1.5g, which is a yellow-brown conical suppository made of Liao Diaozhu, liangmianzhen, Cnidium, rhubarb, wild chrysanthemum and licorice. The sanitary suppository is used for fungal vaginitis, bacterial vaginitis, and damp-heat betting syndrome. The more prominent problem of the drug is that it is less effective for users' genital itching, pain, frequent urination and other symptoms. More importantly, it will induce the above symptoms in patients who have not had such symptoms before, and the incidence is higher. Although those skilled in the field of pharmacy would have thought that the drug formulation would contain ...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K9/02A61K47/44A61P15/02A61P15/00A61P15/18A61P31/10A61P31/04G01G17/00G01N33/15
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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