Use of 1,4-naphthalene diphenol in preparing external use sperm killing contraceptive medicine of preventing and curing genital tract infection

Abstract

The present invention discloses the use of 1, 4-naphthalene diphenol in preparing external use spermicidal contraceptive capable of preventing and treating genital tract infection and the external use spermicidal contraceptive prepared with 1, 4-naphthalene diphenol. The external use spermicidal contraceptive possesses triple functions of diminishing inflammation, birth control and improving sexual life. The spermicidal contraceptive has powerful spermicidal effect 25 times higher than that of nonoxynol nonylphenoxy-polyethoxyethanol, no bacteriostasis on normal lactobacillus inside vagina and effect of defending partial STD pathogens. It has the features of safety, high efficiency and convenience.

Description

technical field [0001] The invention belongs to the field of medicine and health (family planning and contraceptive medicines), in particular to 1,4-naphthohydroquinone (1,4-Naphthohydroquinone / 1,4-Dihydroxynaphthalene, N) for the preparation of external spermicidal contraception for preventing and treating reproductive tract infection The use of the medicine, and Kunbaikang Contraceptive Cream (KBK) (preparation), a kind of external spermicidal and contraceptive medicine for preventing and treating reproductive tract infection prepared by the 1,4-naphthalenediol. Background technique [0002] Among the current various contraceptive measures, although each has its own characteristics, whether it is intrauterine device, tubal ligation and vasectomy, or hormonal oral contraceptives, etc., there are invasiveness or long-term use with large side effects and inappropriate use. Convenience; it may disturb the normal physiological process of the human body, and there are many poten...

AI Technical Summary

Problems solved by technology

[0004] Nonoxynol (NP-9) is the only topical spermicidal contraceptive promoted by the World Health Organization in the world. Although it has a strong spermicidal effect, many studies in recent years have proved that it has hepatic-enteric circulation in the body. , has the ability to accumulate in the body, is toxic to the liver and kidney, and does not have the effect of preventing and treating reproductive tract infections

In 2002, the Cochrane Library published a meta-analysis of all available studies, which concluded that NP-9 may be harmful because it increases the incidence of reproductive tract damage and thus may increase the likelihood of transmission of STDs

[0005] In addition, although there are many other reports on external use of spermicidal contraceptives at home and abroad, such as Chinese herbal medicine pokeweed saponin, achyranthes saponin, pig bile (ZDZ), black plum, cnidium, matrine and western medicine phenylmercuric acetate, chloride Benzethoxyamine, dextropropranolol, sodium morrhuate, phytohemagglutinin, phenolic, phenolic ketones, phenolic acid compounds, benzalkonium chloride (BZN), chlorhexidine (CH), sulfonated polystyrene and miconazole, etc., but they are all in experimental research, and because of their relatively high toxicity and low spermicidal efficacy, they have not been reported to be used in clinical practice.

Moreover, the known vaginal spermicide contraceptives have a certain damage effect on women's vaginal epithelial cells, and more can also affect the normal flora in the vagina

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