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High-bioactivity ganoderma spore oil and supercritical preparation method thereof

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum spore powder, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc. It can solve the problems of failing to meet the requirements of freezing and transparent experiments and affecting the appearance of products, so as to avoid acidification and corruption and reduce losses.

Active Publication Date: 2013-03-20
厦门爱逸零食研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ganoderma lucidum spore oil is easy to crystallize at low temperature, which does not meet the national edible oil freezing and transparency test requirements (>5.5h), which affects the appearance of the product. At present, there is no patent to improve this situation

Method used

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  • High-bioactivity ganoderma spore oil and supercritical preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] Weigh 300g of Ganoderma lucidum spore powder, dry at 50°C for 8h, and then put it into a tank. According to the ball-to-material ratio of 2:1, the ratio of large beads to small beads is 1:1:1, and the treatment time is 5 hours. After completion, it is taken out, and the grinding medium is separated to obtain broken-wall spore powder. Mix the broken spore powder with 2% corn starch, put it into a dry press granulator to make 15-mesh granules, put it into a supercritical CO2 extraction kettle, put the absorbent cotton in the middle of the filter paper into the filter plate of the extraction kettle, The extraction pressure is 35MPa, the temperature is 40°C, and the extraction is 90min; add 20% absolute ethanol as an entrainer, and extract for 90min; the pressure of the separation tank I is 5.5MPa, and the temperature is 35°C; At 30°C, the extract was taken out from the separation kettle to obtain a light yellow oily liquid, and the entrainer was recovered by rotary evapora...

Embodiment 2

[0030] Weigh 400g of Ganoderma lucidum spore powder, dry at 50°C for 8h, and then put it into a tank. According to the ball-to-material ratio of 2.5:1, the ratio of large beads to small beads is 1:1:1, and the treatment time is 6 hours. After the treatment is completed, it is taken out, and the grinding medium is separated to obtain the broken spore powder. Mix the broken spore powder with 3% corn starch, put it into a dry press granulator to make 20-mesh granules, put it into a supercritical CO2 extraction kettle, put the absorbent cotton in the middle of the filter paper into the filter plate of the extraction kettle, Extraction pressure 30MPa, temperature 30°C, extraction 100min; add 25% absolute ethanol as entrainer, extraction 90min; separation tank I, pressure 5MPa, temperature 38°C; separation tank II pressure 6MPa, temperature 32°C , the extract was taken out from the separation tank to obtain a light yellow oily liquid, and the entrainer was recovered by rotary evapor...

Embodiment 3

[0033]Weigh 500g of Ganoderma lucidum spore powder, dry at 50°C for 10h, and then put it into a tank. According to the ball-to-material ratio of 3:1, the ratio of large beads to small beads is 1:1:1, and the treatment time is 7 hours. After completion, it is taken out, and the grinding medium is separated to obtain broken-wall spore powder. Mix the broken spore powder with 5% corn starch, put it into a dry press granulator to make 10-mesh granules, put it into a supercritical CO2 extraction kettle, put the absorbent cotton in the middle of the filter paper into the filter plate of the extraction kettle, Extraction pressure 38MPa, temperature 35°C, extraction 110min; then add 30% absolute ethanol as entrainer, extraction 60min; separation tank I, pressure 5MPa, temperature 40°C; separation tank II pressure 6MPa, temperature 35°C , the extract was taken out from the separation tank to obtain a light yellow oily liquid, and the entrainer was recovered by rotary evaporation. Put ...

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Abstract

The invention aims to disclose high-bioactivity ganoderma spore oil and a preparation method thereof, and belongs to the field of Chinese medicament. The method comprises the following steps: breaking walls of ganoderma spore powder by adopting a high-energy nano impact mill, performing dry granulation, supercritical CO2 extraction, molecular distillation and purification, and thus obtaining the ganoderma spore oil. The operation process of the method is carried out in an anhydrous environment, so that oxidation of the spore oil in the processing process is reduced, and the obtained product is stable in property; the freezing transparent test time of the ganoderma spore oil prepared by the method exceeds 5.5 hours; and the measured unsaturated fatty acid content is between 60 and 80 percent, the total triterpenoid content is 2 to 3 percent, the total ergosterol content is 2 to 5 mg / g, the ganoderic acid A content is more than 1 mg / g, the peroxide value is less than 5mmol / kg, and the acid value is less than 10 mg KOH / g.

Description

Technical field: [0001] The invention relates to a ganoderma lucidum spore oil with high biological activity, which belongs to the field of traditional Chinese medicine. It also relates to a high-energy nanometer impact milling method for wall breaking of ganoderma lucidum spore powder and a preparation method of supercritical CO2 extraction and molecular distillation purification of the ganoderma spore oil. Background technique: [0002] Ganoderma lucidum spores are the sexual reproductive cells of Ganoderma lucidum. They contain all the genetically active substances of Ganoderma lucidum. They have anti-tumor, blood sugar-lowering and immune-regulating effects. They have applications in pharmacology and clinical practice, and are also a good raw material for natural health care products. Ganoderma lucidum spores are rich in polysaccharides, triterpenoids, polypeptides, nucleic acids, organic germanium and other anti-tumor substances, and Ganoderma lucidum triterpenoids are ...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61P35/00A61P3/10A61P37/02
Inventor 刘元法张新新李进伟王兴国
Owner 厦门爱逸零食研究所有限公司
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