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Nano-hydrogel with oxidation-reduction/pH double-stimulation responsiveness and preparation method and application thereof

A nano-hydrogel and gel technology, which is applied in the field of biomedicine, can solve the problems of human side effects and low dosage, and achieve the effect of reducing side effects and clear and concise preparation process

Inactive Publication Date: 2013-03-20
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] According to a large number of studies, doxorubicin is an effective anticancer drug, but the dose that reaches the tumor tissue through the body fluid circulation after direct injection is very low, and it will bring serious side effects to the human body

Method used

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  • Nano-hydrogel with oxidation-reduction/pH double-stimulation responsiveness and preparation method and application thereof
  • Nano-hydrogel with oxidation-reduction/pH double-stimulation responsiveness and preparation method and application thereof
  • Nano-hydrogel with oxidation-reduction/pH double-stimulation responsiveness and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of PMAA nano hydrogel

[0032] MAA monomer 500 mg, BACy crosslinker 55.6 mg, AIBN initiator 16.7 mg, 40 mL acetonitrile, heated to 82 o C, 20 mL of solvent was distilled off, the solvent and unreacted monomer were removed by centrifugation, washed three times with ethanol and deionized water, and dried in a vacuum oven for 24 h.

Embodiment 2

[0033] Embodiment 2: Preparation of PAA nano hydrogel

[0034] AA monomer 500 mg, BACy crosslinker 55.6 mg, AIBN initiator 16.7 mg, 40 mL acetonitrile-ethanol mixed solvent (V 乙腈 :V 乙醇 =1:1), heated to 82 o C, 20 mL of solvent was distilled off, the solvent and unreacted monomer were removed by centrifugation, washed with acetone and deionized water three times, and dried in a vacuum oven for 24 h.

Embodiment 3

[0035] Embodiment 3: the preparation of PMAA-co-PHPMA nano hydrogel

[0036] MAA monomer 250 mg, HPMA 250 mg, BACy crosslinker 55.6 mg, AIBN initiator 16.7 mg, 40 mL acetonitrile-toluene mixed solvent (V 乙腈 :V 甲苯 =4:1), heated to 82 o C, 20 mL of solvent was distilled off, the solvent and unreacted monomer were removed by centrifugation, washed with acetone and deionized water three times, and dried in a vacuum oven for 24 h.

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Abstract

The invention belongs to the technical field of biological medicine, and in particular relates to a nano-hydrogel with oxidation-reduction / pH double-stimulation responsiveness and a preparation method and application thereof. The preparation method comprises the following steps of: adding a polymerized monomer and a crosslinking agent into a solvent to perform a polymerization reaction, and distilling the deposits to remove a half of the solvent; removing the solvent and the unreacted monomer, and drying to obtain polymer gel particles; or further modifying different functional groups such as on-belt amino groups and the like, and performing a reaction on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) / N-hydroxysuccinimide (NHS) and amino-folic acid to obtain folate-targeted nano-hydrogel particles. The nano-hydrogel is in morphologically regular spherical shape, uniform in size and controllable in particle size, has oxidation-reduction and pH double-stimulation responsiveness, good colloidal stability and dispersity, is used as a drug carrier, and can be easily discharged out of a body through the kidney during subsequent in vivo metabolism.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a nano hydrogel and its preparation method and application, and further relates to a nano hydrogel with redox / pH dual stimulus responsiveness and a preparation method thereof, and the nano hydrogel Application as a drug carrier. Background technique [0002] According to a large number of studies, doxorubicin is an effective anticancer drug, but the dose that reaches the tumor tissue through the body fluid circulation after direct injection is very low, and it will bring serious side effects to the human body. There have been many studies in the world to develop target-targeted drug delivery systems (drug delivery systems, dds) to enhance drug efficacy and reduce side effects. These drug carriers include various forms of micelles, nanoparticles, microcapsules, and nanohydrogels. Glue etc. [0003] Among various drug carriers, polymer nanohydrogel is an ideal drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61K31/704A61P35/00
Inventor 汪长春潘元佳
Owner FUDAN UNIV
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