Nano-hydroxyapatite/chitosan/chondroitin sulfuric acid composite stent

A technology of nano-hydroxyapatite and chondroitin sulfate, which is applied in the fields of medical science and prostheses, can solve problems such as uneven dispersion of hydroxyapatite, decline in mechanical properties of materials, and weak interface binding force, so as to promote adhesion and growth, improved mechanical properties, and controllable crystallinity

Inactive Publication Date: 2013-02-13
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the composite material prepared by simple compounding, the dispersion of hydroxyapatite is uneven, agglomeration is easy to occur, and the interface bonding force is weak, which makes the mechanical properties of the material decrease and the microstructure is disordered.

Method used

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  • Nano-hydroxyapatite/chitosan/chondroitin sulfuric acid composite stent
  • Nano-hydroxyapatite/chitosan/chondroitin sulfuric acid composite stent
  • Nano-hydroxyapatite/chitosan/chondroitin sulfuric acid composite stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Prepare 2mol / L calcium nitrate salt solution and 1.2mol / L potassium dihydrogen phosphate solution; the mass ratio of chitosan and chondroitin sulfate is 10:1;

[0028] 2) Dissolve the chitosan / chondroitin sulfate in the mass ratio in 1% acetic acid solution, and stir evenly;

[0029] 3) Slowly add a certain amount of calcium nitrate salt solution and potassium dihydrogen phosphate solution to the above chitosan / chondroitin sulfate mixture, and stir for 1 hour; where n(Ca 2+ ):n(PO 4 3- )=1.67:1, the mass ratio of organic components to theoretically formed HAP is 1:0.4;

[0030] 4) Add the cross-linking agent EDC / NHS, the concentration of EDC is 2 mg / mL, the molar ratio of EDC / NHS is 1.5:1, cross-link at room temperature for 6 hours; the final mixture is poured into the mold, moved to a refrigerator at 4°C for 4 hours, and then Freeze in a -10°C ultra-low temperature refrigerator for at least 12 hours, then transfer to a freeze dryer to freeze dry until completely ...

Embodiment 2

[0034] 1) Prepare 2mol / L calcium nitrate solution and 0.6mol / L potassium dihydrogen phosphate solution; the mass ratio of chitosan and chondroitin sulfate is 5:1;

[0035] 2) Dissolve the chitosan / chondroitin sulfate in the ratio in 1% acetic acid solution, and stir evenly;

[0036] 3) Slowly add a certain amount of calcium nitrate solution and potassium dihydrogen phosphate solution to the uniformly mixed chitosan / chondroitin sulfate mixture, and stir for 1 hour; where n(Ca 2+ ):n(PO4 3- )=1.67:1, the mass ratio of organic components to theoretically formed HAP is 1:0.5;

[0037] 4) Add cross-linking agent EDC / NHS, the concentration of EDC is 2.5 mg / mL, the molar ratio of EDC / NHS is 2:1, cross-link at room temperature for 5 hours; the final mixture is poured into the mold, moved to 4 ° C refrigerator for 4 hours, and then Freeze in a -20°C ultra-low temperature refrigerator for at least 12 hours, then transfer to a freeze dryer to freeze dry until completely dehydrated;

...

Embodiment 3

[0041] 1) Prepare 1mol / L calcium nitrate solution and 1.2mol / L disodium hydrogen phosphate solution; the mass ratio of chitosan and chondroitin sulfate is 10:3;

[0042] 2) Dissolve the chitosan / chondroitin sulfate in the ratio in 1% acetic acid solution, and stir evenly;

[0043] 3) Slowly add a certain amount of calcium nitrate solution and disodium hydrogen phosphate solution to the homogeneously mixed chitosan / chondroitin sulfate mixture, and stir for 1 hour; where n(Ca 2+ ):n(PO 4 3- )=1.67:1, the mass ratio of organic components to theoretically formed HAP is 1:0.6;

[0044] 4) Add cross-linking agent EDC / NHS, the concentration of EDC is 3 mg / mL, the molar ratio of EDC / NHS is 2.5:1, cross-link at room temperature for 5 hours; the final mixture is poured into the mold, moved to 4 °C refrigerator for 6 hours, and then put Freeze in a -80°C ultra-low temperature refrigerator for at least 12 hours, and then transfer to a freeze dryer to freeze-dry until completely dehydra...

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Abstract

The invention discloses a nano-hydroxyapatite / chitosan / chondroitin sulfuric acid composite stent with high biological response and a preparation method of the nano-hydroxyapatite / chitosan / chondroitin sulfuric acid composite stent. The preparation method comprises the steps of: using chitosan / chondroitin sulfuric acid as an organic matrix and using a calcium-phosphor salt solution as an inorganic phase precursor; fully uniformly mixing a chitosan / chondroitin sulfuric acid acetic acid solution with a soluble calcium-phosphor salt solution, crosslinking with a crosslinking agent, carrying out injection molding and forming, carrying out in-situ biomimetic mineralization crystallization in alkaline liquor, freezing and drying to obtain the nano-hydroxyapatite / chitosan / chondroitin sulfuric acid composite stent with high biological response. The preparation method can be used for simulating a composition and a structure of natural bone on the aspect of material preparation, is mild in preparation condition, and is simple to operate; and the prepared material can be randomly shaped and re-machined according to the use demand.

Description

technical field [0001] The invention belongs to the technical field of artificial bone repair materials, and in particular relates to a high biological response nano-hydroxyapatite / chitosan / chondroitin sulfate composite scaffold and a preparation method thereof. Background technique [0002] Human bone tissue is a naturally mineralized biomaterial with a highly precise structure assembled from weakly crystalline nano-hydroxyapatite and collagen. In a broad sense, it can be regarded as a dual-phase composite material or an organic / inorganic nanocomposite material containing nanocrystals in the matrix, which provides inspiration and inspiration for the research and development of bone repair materials. Nano-hydroxyapatite bone repair composite Materials came into being. The so-called nanocomposite material refers to the composite material whose dispersed phase size is at least less than 100nm. Due to the large interface area between the dispersed phase and the matrix, the pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46
Inventor 陈景帝余其凤张惠张玉珏张其清
Owner FUZHOU UNIV
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