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Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials

A microfluidic chip and polymer technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of microfluidic chip integration, miniaturization, popularization, and limited applications. problem, to achieve the effect of easy control of process parameters, shortened bonding time, and low process cost

Inactive Publication Date: 2014-12-10
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This is contrary to the purpose of popularizing microfluidic chips through integration and miniaturization, thus limiting their application in various fields

Method used

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  • Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials
  • Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials
  • Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials

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Experimental program
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specific Embodiment approach 1

[0025] Specific implementation mode 1: Firstly, two absorbing and heating substrates with flat surfaces are prepared, and the mass ratio of the doped absorbing material is 27%. During preparation, an appropriate amount of substances capable of generating heat under microwave radiation is mixed into the heating substrate material. Align and cover the two substrates of the chip. Place a heated substrate horizontally into a closed container with an electromagnetic wave generator, and then place the microfluidic chip (including the substrate and cover) on the heated substrate. Afterwards, another heating substrate is horizontally covered on the microfluidic chip. After putting the chip and heating substrate into the airtight container, close the container. Wherein, the size of the microchannel on the microfluidic chip is 156 μm×150 μm. The electromagnetic wave power is set to 800W, the timing is 40 seconds, the bonding temperature is controlled within the range of 95-200° C., a...

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Abstract

The invention discloses a bonding method for a micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials and relates to a bonding method for the micro-fluidic chip. The bonding method disclosed by the invention comprises the following steps of: respectively gluing two prefabricated wave-absorbing heating substrates with the upper surface and the lower surface of the chip; then, putting in a closed container; and performing radiation heating in the closed container by using a high-frequency electromagnet wave, wherein the microwave power is 400-1000W, the highest transient temperature range of a bonding interface is controlled to be 95-200 DEG C, and the bonding time is 30-200S, Compared with other domestic and overseas bonding methods for the polymeric micro-fluidic chip, the novel bonding method is simple in required equipment, low in process cost and few in step and can be easily popularized and applied in the field of bonding the micro-fluidic chip based on the polymeric materials.

Description

technical field [0001] The invention relates to a bonding method of a microfluidic chip, in particular to a bonding method of a microfluidic chip based on PMMA (polymethyl methacrylate, commonly known as plexiglass) and other organic polymer materials. Background technique [0002] A microfluidic chip refers to the miniaturization of a biological or chemical laboratory onto a sheet of only a few square centimeters through microfabrication technology and other processing methods. A chemical or biological laboratory built on a chip can integrate basic operating units such as sample preparation, reaction, separation, detection, cell culture, sorting, and lysis involved in the fields of chemistry and biology. Ultimately, the above-mentioned operating units can be integrated into a very small chip, and a network of microchannels can be used to run through the entire system with controllable fluids to realize various functions in conventional chemical or biological laboratories. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 刘晓为韩小为王蔚田丽张贺
Owner HARBIN INST OF TECH
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