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Application of stizolobium cochinchinensis seed extract to preparation of medicament for treating Parkinson's disease accompanied by sleep disorder

A technology for Parkinson's disease and sleep disorders, applied in the field of traditional Chinese medicine, can solve the problems of Parkinson's disease that have not yet been seen, and achieve the effect of low price, high bioavailability, and high safety

Inactive Publication Date: 2013-01-23
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of cat bean compound extracts in the treatment of Parkinson's disease with sleep disorders

Method used

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  • Application of stizolobium cochinchinensis seed extract to preparation of medicament for treating Parkinson's disease accompanied by sleep disorder
  • Application of stizolobium cochinchinensis seed extract to preparation of medicament for treating Parkinson's disease accompanied by sleep disorder
  • Application of stizolobium cochinchinensis seed extract to preparation of medicament for treating Parkinson's disease accompanied by sleep disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 extracts levodopa and feline guanidine from cat bean medicinal material

[0037] Extract levodopa: use 732 type strong acidic cation exchange resin, dissolve levodopa with 0.2mol / L hydrochloric acid solution, use ion exchange chromatography column method to do static adsorption and dynamic adsorption of levodopa solution, and then use 0.3 The mol / L ammonia water was used as the eluent for dynamic elution and collection. The eluate is collected in two parts; the main component of the first part of the eluate is levodopa, accounting for about 3.52% of the total amount of cat beans; the second part of the eluate is separated and purified to obtain madoguanidine (MDG), accounting for about 0.27% of cat bean total amount; (Huang Zengqiong, Jiang Weizhe etc., 717 type anion exchange resins separate the preparation method of cat bean guanidine in cat bean. Drug Research. The 12th phase of volume 18 in 2009, the 23-24 page), adopt High-pressure liquid chromatograp...

Embodiment 2

[0040] Embodiment 2 animal experiments

[0041] 1) Influence experiment of mouse autonomous activity: get 30 mice, be divided into 3 groups at random, i.e. blank control group (distilled water 10mL / kg), positive control group (stable 1mg / kg), medicine group of the present invention: contain cat bean Guanidine / Levodopa (MDG / DL) 350 / 125mg / kg;

[0042] Before administration, each mouse was put into the activity box of the animal behavior analysis system to adapt for 5 minutes, and the movement distance and shuttle times of the mice were recorded within 2 minutes, and then the mice in each group were administered ig once, and after 60 minutes of administration, the mice were measured in the same way. Mouse activity distance and shuttle times.

[0043] 2) Effect experiment on sleep of mice with subthreshold hypnotic dose of pentobarbital sodium: animal grouping and administration method are the same as item 1). After 30 minutes of administration, mice in each group were given ip ...

Embodiment 3

[0064] Embodiment 3 toxicity and side effects experiment

[0065] Get 12 male and female pigeons of healthy pigeons, divide into two groups of cat bean compound extract medicine group (n=6) and cat bean powder group (n=6) of the present invention, in the medicine group of the present invention, cat bean guanidine / L-poly Ba (MDG / DL) was 350 / 125mg / kg, and the cat bean powder group was cat bean powder 450mg / kg, and the test pigeons were fed with cold boiled water 10ml / kg for 14 days, once a day, and fasted for 24 hours before the experiment. Drugs were given by gavage, and the emesis latency and times of emesis (vomiting frequency) of each group were recorded. The results showed that after feeding the medicine, 5 domestic pigeons (83.33%) in the cat bean powder group experienced vomiting in varying degrees, and the number of vomiting was 1-4 times, with an average of 2.2 times. The earliest occurrence was when the cat bean powder was fed for 24 minutes. Only domestic pigeon (100...

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Abstract

The invention belongs to the field of Chinese medicine pharmacy, and relates to an application of a stizolobium cochinchinensis seed extract to preparation of a medicament for treating a Parkinson's disease accompanied by sleep disorder. The stizolobium cochinchinensis seed extract mainly comprises levodopa and stizolobium cochinchinensis seed guanidine components which are purified and combined respectively for preparing a medicament for treating Parkinson's diseases accompanied by sleep disorder of mammals including human beings. As proved by the result of an animal experiment, the stizolobium cochinchinensis seed compound extract can be used for improving the sleeping effect, and has a similar hypnotic effect to a calming effect; the pentobarbital sodium sleeping time can be prolonged, and the anti-shock effect is similar to that of levodopa; and the toxic and side effects are weak. The stizolobium cochinchinensis seed compound extract disclosed by the invention has the advantages of higher bioavailability, shorter response time, longer action maintaining time and the like, can be used for effectively treating Parkinson's diseases accompanied by sleep disorder of mammals including human beings, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the medicinal use of a Chinese medicinal material cat bean extract, in particular to the use of the cat bean extract in preparing and treating Parkinson's disease accompanied by sleep disorder. Background technique [0002] Parkinson's disease (PD), also known as Parkinson's paralysis, is the second most common neurodegenerative disease. In addition to resting tremor, bradykinesia, increased muscle tone, and posture maintenance disorders and other motor symptoms, it is often accompanied by depression and mental disorders. , dementia, autonomic nervous system dysfunction, and nocturnal sleep disturbance; among them, sleep disturbance is the most important non-motor disorder symptom of PD, which seriously affects the quality of life of patients; sleep disturbance often appears in the early stage of PD, and research shows that it is mainly related to brainstem sleep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K31/198A61P25/16A61P25/20
Inventor 潘卫东刘云吴春岚孙燕支惠萍方正龙
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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