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Diclofenac sodium sustained-release capsule and preparation method thereof

A technology of diclofenac sodium and sustained-release capsules, which is applied in the field of medicine, can solve the problems of many types and components of excipients, and the release degree and stability need to be further improved, and achieve the effects of excellent release curve, maintaining effective concentration and increasing curative effect.

Active Publication Date: 2015-06-17
NANJING CHANGAO PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Diclofenac Potassium Sustained-release Pellets of the above-mentioned patents use many types and components of excipients, and their release and stability need to be further improved.

Method used

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  • Diclofenac sodium sustained-release capsule and preparation method thereof
  • Diclofenac sodium sustained-release capsule and preparation method thereof
  • Diclofenac sodium sustained-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Diclofenac Sodium Sustained Release Capsules Prescription Composition and Preparation Method

[0026]

[0027] The preparation steps are:

[0028] (1) 1g hypromellose K30 is added to 4.5 times the weight of 95% ethanol, stirred and dissolved; the prescription amount of diclofenac sodium is added to the above solution, stirred and dissolved;

[0029] (2) Add 150g blank pellet cores to the granulator, turn on the temperature and compressed air, and slowly spray the medicinal solution (1) onto the blank pellet cores to prepare drug-containing pellet cores;

[0030] (3) dissolving 10g ethyl cellulose and 2g diethyl phthalate, 4.5g talcum powder, 2g hypromellose with 10 times the weight of 95% ethanol solution to make a slow-release coating solution;

[0031] (4) Evenly spray the prepared sustained-release coating solution (3) on the surface of the prepared drug-containing pellets, and then place the obtained sustained-release pellets in a vacuum drying oven at...

Embodiment 2

[0033] Example 2 Diclofenac Sodium Sustained Release Capsules Prescription and Preparation Method

[0034]

[0035] The preparation steps are:

[0036] (1) 1.8g hypromellose K30 is added to 4.5 times the weight of 95% ethanol, stirred and dissolved; the prescription amount of diclofenac sodium is added to the above solution, stirred and dissolved;

[0037] (2) Add 150g blank pellet cores to the granulator, turn on the temperature and compressed air, and slowly spray the medicinal solution (1) onto the blank pellet cores to prepare drug-containing pellet cores;

[0038] (3) dissolving 15g cellulose acetate, 3g triethyl citrate, 5g magnesium stearate, 3.6g hypromellose with 11 times the weight of 95% ethanol solution to make a slow-release coating solution;

[0039](4) Sprinkle the prepared sustained-release coating solution (3) evenly on the surface of the prepared drug-containing pellets, and then place the obtained sustained-release pellets in a vacuum drying oven at 70°C...

Embodiment 3

[0041] Example 3 Diclofenac Sodium Sustained Release Capsules Prescription and Preparation Method

[0042]

[0043] The preparation steps are:

[0044] (1) 2g hypromellose is added in 95% ethanol of 3.5 times of weight, stirring and dissolving; Diclofenac sodium of recipe quantity is added in the above-mentioned solution, stirring and dissolving;

[0045] (2) Add 150g blank pellet cores to the granulator, turn on the temperature and compressed air, and slowly spray the medicinal solution (1) onto the blank pellet cores to prepare drug-containing pellet cores;

[0046] (3) Dissolve 15g of cellulose acetate and 3g of triacetin, 5g of micropowdered silica gel, and 6g of hypromellose with 95% ethanol solution of 10 times the weight to make a slow-release coating solution;

[0047] (4) Sprinkle the prepared sustained-release coating solution (3) evenly on the surface of the prepared drug-containing pellets, and then place the obtained sustained-release pellets in a vacuum dryin...

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Abstract

The invention provides an anti-inflammation analgesia medicine, particularly provides a diclofenac sodium sustained-release capsule and a production method thereof. The preparation method of the diclofenac sodium sustained-release capsule includes that diclofenac sodium is prepared to be a sustained-release pellet, and the sustained-release pellet is filled in the capsule. The diclofenac sodium sustained-release pellets is composed of a blank pellet core serving as a parent nucleus, a main medicine layer and a sustained-release coating layer, the main medicine layer contains the diclofenac sodium and is coated outside the pellet core, and the sustained-release coating layer is coated outside the main medicine layer. The diclofenac sodium sustained-release capsule has the advantages that the preparation stability is good, the releasing effect is remarkably excellent, and compared with common capsules, the diclofenac sodium sustained-release capsule is safe and convenient for a patient to take in.

Description

technical field [0001] The invention relates to a sustained-release preparation, in particular to a diclofenac sodium sustained-release capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Diclofenac sodium is a non-steroidal anti-inflammatory drug, and its active ingredient is diclofenac, which mainly produces analgesic, anti-inflammatory and antipyretic effects by inhibiting the synthesis of prostaglandins. It has a good therapeutic effect on joint pain caused by rheumatoid arthritis, rheumatoid arthritis, degenerative osteoarthritis, gout, soft tissue inflammation around the joint, and injury. Its curative effect is better than other steroidal drugs such as indomethacin, aspirin, fenbid, naproxen, etc., and it is absorbed quickly, has fewer side effects, and has lighter gastrointestinal reactions than most non-steroidal anti-inflammatory drugs, and is well tolerated. Small and individual differences are sma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/196G01N30/02A61P29/00
Inventor 吴苏敏李战吴小涛宋祥珍薛晓兵
Owner NANJING CHANGAO PHARM CO LTD
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