Ozagrel sodium drug combination for injection
A technology of ozagrel sodium and its composition, which is applied in the field of ozagrel sodium pharmaceutical composition and its preparation, which can solve the problems of inconvenient use, storage and transportation, etc., and achieve the reduction of market risk, the method is simple and easy, and there is no allergic reaction Effect
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Embodiment 1
[0061] The ozagrel sodium pharmaceutical composition described in every 1000 bottles, its formula consists of:
[0062]
[0063] Preparation process: Take 70% of the prescribed amount of water for injection, at a temperature of 50-60°C, add the prescribed amount of mannitol and anhydrous sodium bicarbonate, stir and dissolve; add the prescribed amount of ozagrel sodium, stir until completely dissolved; measured Initial pH value, according to the initial pH value, use 4% sodium hydroxide solution to adjust the pH value range to 7.7-8.7; add 0.05% medicinal charcoal to the mixture, stir at 50-60 °C for 30 minutes; suction filter, add water for injection to Full volume, mixed evenly; fine filtration; filling; freeze-drying: put the filled glass bottle into a freeze-drying box that has been cooled down to 5°C, quickly cool down to -40°C, keep warm and freeze for 3 hours, and then vacuumize , raise the temperature to -5°C within 3 hours, maintain the time at -5°C for 10-15 hours...
Embodiment 2
[0065] The ozagrel sodium pharmaceutical composition described in every 1000 bottles, its formula consists of:
[0066]
[0067] Preparation process: with embodiment 1.
Embodiment 3
[0069] The ozagrel sodium pharmaceutical composition described in every 1000 bottles, its formula consists of:
[0070]
[0071] Preparation process: with embodiment 1.
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