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Gas/liquid chromatogram-electron bombardment electrospray dual-ion-source flight time mass spectrum system

A technology of time-of-flight mass spectrometry and electron bombardment of ions, which is applied in the field of scientific instruments, can solve the problems of weakening the advantages of chromatography-mass spectrometry technology, difficult simultaneous analysis and reduction of various forms of samples, etc.

Inactive Publication Date: 2012-11-28
王利兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is precisely because of the high specificity of chromatography-mass spectrometry that the single-mode gas chromatography-, liquid chromatography-, and thin-layer chromatography-mass spectrometry techniques are difficult to apply to samples in various forms (gas, liquid, etc.) or solid state); in addition, when developing a chromatographic-mass spectrometry detection method for compounds with unknown properties, it is necessary to use gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry at the same time. The approach not only requires an expensive chromatographic-mass spectrometer as a guarantee, but each chromatographic-mass spectrometer has different requirements for sample pretreatment, calibration of its own performance status, data recording and operating system, which virtually reduces and Weaken the advantages of chromatography-mass spectrometry in the qualitative and quantitative analysis of trace organic compounds

Method used

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  • Gas/liquid chromatogram-electron bombardment electrospray dual-ion-source flight time mass spectrum system
  • Gas/liquid chromatogram-electron bombardment electrospray dual-ion-source flight time mass spectrum system
  • Gas/liquid chromatogram-electron bombardment electrospray dual-ion-source flight time mass spectrum system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Gas chromatography-electron bombardment-time-of-flight working mode.

[0030] like figure 2 and Figure 4 As shown, after the control terminal (403) issues an instruction, the automatic sampling needle (102) searches for the specified sample vial on the sample tray (101) according to the instruction, draws a certain volume of sample solution and injects it into the injection port, and the sample is vaporized The high-purity helium flow provided by the carrier gas cylinder (106) enters the quartz capillary column (104) for adsorption / separation, and the separated samples enter the bombardment ionization chamber (240) of the electron bombardment ion source with the helium flow. The vacuum degree of the ionization chamber (240) reaches 10 under the joint action of the foreline mechanical pump and the molecular turbo pump (235) connected to the vacuum evacuation (206). -4 below pa; the voltage loaded on the filament (238) excites the filament (238) to emit ele...

Embodiment 2

[0032] Example 2 Liquid chromatography-electrospray-time-of-flight working mode.

[0033] like image 3 and Figure 4 As shown, after the control terminal (403) sends an instruction, the autosampler (303) extracts the sample in the sample bottle, and under the action of the hydraulic pump (305), it enters the online mixer (304) together with the mobile phase and mixes evenly. Then flow into the chromatographic column (306) for adsorption / separation, select and control the flow direction through the six-way valve (307), and then inject the electrospray nozzle (201) along the liquid pipeline (308), and the high pressure at the tip of the electrospray nozzle (201) The outflowing liquid droplets are ionized in the electric field; the charged liquid droplets are rapidly atomized and desolvated in the spray chamber (202), and then the charged ions flow through the electrospray stainless steel capillary conduit (204) into the mass spectrometer vacuum chamber (207), and Desolvation ...

Embodiment 3

[0035] Example 3 Gas-liquid chromatography-electron bombardment electrospray-time-of-flight working mode.

[0036] like figure 2 , image 3 and Figure 4 As shown, while the autosampler (102) extracts the sample in the sample tray (101) for gas chromatography-electron bombardment-time-of-flight mode analysis, the autosampler (303) extracts the sample in the sample bottle and enters the chromatographic column ( 306) for liquid chromatography-electrospray-time-of-flight analysis. While the gaseous sample in the quartz capillary column is ionized in the bombardment ionization chamber (240) according to the approach and method shown in Example 1, the liquid sample is ionized in the electrospray nozzle of the electrospray ion source according to the approach shown in Example 2. (201) Ionization at the needle tip; the electron bombardment ion beam (243) introduced vertically from the Z direction through the electric lens group (241) and the electrospray ion beam (242) vertically...

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Abstract

The invention provides a gas / liquid tandem mass spectrum system with a multimode ionization ion source. The gas / liquid tandem mass spectrum system is characterized by being formed by connecting a multimode ionization ion source, a gas chromatography, a Liquid Chromatography, a mass analyzer with purification and enrichment functions, and a flight time mass spectrometry in series. According to the invention, the applicability of a single-ion-source mass spectrometry specific to analysis of polymorphic samples is broadened, meanwhile, the high resolution performance of fragment ions on mass selection and analysis is enhanced, and the researches on an ionic reaction mechanism are realized.

Description

technical field [0001] The invention belongs to the technical field of scientific instruments, and in particular relates to a gas-phase liquid chromatography-electron bombardment electrospray dual ion source tandem mass spectrometry system. Background technique [0002] Chromatography-mass spectrometry technology, which combines the powerful separation and quantification capabilities of chromatography with the precise qualitative function of mass spectrometry (MS), is one of the powerful technical means for analyzing the content of small organic molecules and the speciation of inorganic elements. In the existing chromatography-mass spectrometry technology, the chromatographic techniques involved include gas chromatography (GC), liquid chromatography (LC), thin layer chromatography (TLC) and ion chromatography (IC). The corresponding technologies include quadrupole (Q) mass spectrometers, ion trap (IT) mass spectrometers, and time-of-flight (TOF) mass spectrometers. In the p...

Claims

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Application Information

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IPC IPC(8): H01J49/04G01N30/02G01N30/72
Inventor 王利兵丁利清江于艳军苏荣欣胥传来侯尧
Owner 王利兵
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