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Degradable Fe-Mn-C ternary iron alloy material and its application

A fe-mn-c, ferroalloy technology, applied in medical science, surgery, etc., can solve the problem of low degradation speed, achieve low magnetic properties, long plasma recalcification time, and excellent compatibility

Active Publication Date: 2014-12-10
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the problem that the degradation rate of pure iron and Fe-30Mn alloy in the prior art is too low in the human body environment, the purpose of the present invention is to provide a Fe-Mn-C ternary iron alloy material with a higher biodegradation rate, Another object is to provide a kind of material for cardiovascular stent, peripheral vascular stent

Method used

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  • Degradable Fe-Mn-C ternary iron alloy material and its application
  • Degradable Fe-Mn-C ternary iron alloy material and its application
  • Degradable Fe-Mn-C ternary iron alloy material and its application

Examples

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Embodiment 1

[0020] Fe-Mn-C ternary iron alloy, the mass percentages are: Mn: 30%, C: 1%, the rest is Fe, expressed as Fe-30Mn-1C. Ferroalloy ingots are made by vacuum induction melting. After the ingots are kept at 1050°C for 1 hour, they are forged, air-cooled after forging, and finally forged into round rods with a diameter of Ф25mm.

[0021] The forged ferroalloy is processed into a tensile sample of M10Ф5×25mm, and the mechanical properties of the material are tested on the AG-100kNG mechanical testing machine according to the GB / T 228-2002 standard. The tensile strength is 1010MPa, and the yield strength is 373MPa. The elongation was 88%. Electrochemical impedance spectroscopy in saline at 37°C as figure 1 As shown, compared with Fe-30Mn alloy, Fe-30Mn-1C alloy has lower polarization resistance, indicating its higher degradation rate in physiological environment. The immersion experiment in physiological saline showed that the degradation rate of the alloy was as high as 0.20mm / yea...

Embodiment 2

[0025] The Fe-Mn-C ternary iron alloy has the following mass percentages: Mn: 10%, C: 0.8%, and the balance is Fe. Ferroalloy ingots are made by vacuum induction melting. After the ingots are kept at 1050°C for 1 hour, they are forged, air-cooled after forging, and finally forged into round rods with a diameter of Ф25mm.

[0026] The forged iron alloy is processed into a tensile sample of M10Ф5×25mm, and the mechanical properties of the material are tested on the AG-100kNG mechanical testing machine according to the GB / T 228-2002 standard. The tensile strength is 980MPa, and the yield strength is 310MPa. The elongation is 80%. The immersion experiment in physiological saline showed that the degradation rate of the alloy was as high as 0.18mm / year, and the degradation rate decreased to 0.13mm / year after 14 days, which has a relatively high degradation rate. According to the evaluation method of ISO10993, the cytotoxicity of the material in this example is grade 1, and the hemo...

Embodiment 3

[0028] The Fe-Mn-C ternary iron alloy has the following mass percentages: Mn: 40%, C: 2%, and the balance is Fe. Ferroalloy ingots are made by vacuum induction melting. After the ingots are kept at 1050°C for 1 hour, they are forged, air-cooled after forging, and finally forged into round rods with a diameter of Ф25mm.

[0029] The forged iron alloy is processed into a tensile sample of M10Ф5×25mm, and the mechanical properties of the material are tested on the AG-100kNG mechanical testing machine according to the GB / T 228-2002 standard. The tensile strength is 1035MPa, and the yield strength is 320MPa. The elongation is 75%. The immersion experiment in physiological saline showed that the degradation rate of the alloy was as high as 0.23mm / year, and the degradation rate decreased to 0.18mm / year in 14 days, which has a higher degradation rate. According to the evaluation method of ISO10993, the cytotoxicity of the material in this example is grade 1, and the hemolysis rate is...

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Abstract

The invention relates to a biodegradable Fe-Mn-C ternary iron alloy material in the field of biological medical materials. The alloy material comprises the following components by weight: 1-45% of Mn, 0.5-2.5% of C, and the balance iron. In the invention, the characteristic that the metal iron can corrode in a human body environment so as to be biodegraded is utilized, and Mn and C elements are added into pure iron to improve the corrosion rate of the pure iron in an organism environment, so that after the material is implanted in the body, the degradation time can be shortened, the stimulation on the organism can be reduced, and the treatment effects of medical devices can be improved. The material provided in the invention has good biocompatibility and mechanical properties, as well as better MRI (magnetic resonance imaging) compatibility, thus being able to be used as an intravascular stent material.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a biodegradable Fe-Mn-C ternary iron alloy material and its application. Background technique [0002] Existing non-degradable vascular stents, such as 316L stainless steel stents and Co-based alloy stents, may cause chronic damage to blood vessels if they remain in the human body for a long time, and may cause medial atrophy, aneurysm formation, and reactive intimal hyperplasia in the later stage etc., thus easily leading to the occurrence of intravascular restenosis. The biodegradable vascular stent can degrade and disappear from the body after completing the mechanical support for the diseased blood vessel, so as to completely avoid the occurrence of restenosis in the blood vessel. Polymers and magnesium alloys are two types of biodegradable cardiovascular stent materials that have been extensively studied. However, the poor mechanical properties of the two mate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C38/04A61L31/02
Inventor 谭丽丽徐文利杨柯任伊宾
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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