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Use method for chicken coccidiosis vaccine suspending agent and preparation method for suspension

Inactive Publication Date: 2012-10-17
烟台青大生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When drinking water for immunization, the mixed vaccine oocysts are easy to precipitate, so the vaccine oocysts obtained by chickens during drinking water immunization will have large differences and poor uniformity

Method used

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  • Use method for chicken coccidiosis vaccine suspending agent and preparation method for suspension
  • Use method for chicken coccidiosis vaccine suspending agent and preparation method for suspension
  • Use method for chicken coccidiosis vaccine suspending agent and preparation method for suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Contains 6 ml of sporulated oocyst liquid of 4 kinds of chicken coccidia (a total of 60,000 sporulated oocysts of chicken coccidia), shake well, and divide into 6 parts of 1 ml each. Sixty 4-day-old chickens were divided into 6 groups with 10 chickens in each group. Get wherein 5 kinds (methylcellulose, hydroxyethylmethylcellulose, hydroxypropylmethylcellulose, hydroxybutylmethylcellulose, hydroxypropylcellulose) of the cellulose ether mentioned in this invention, heat respectively After stirring the water, pour it into low-temperature water to make a 0.25% solution, take 9 ml of each solution and mix it with 1 part of coccidioides sporulated oocyst fluid, and inoculate 1 group of chickens with 1 ml of each chicken; Chickens in group 6 were not added with cellulose ether solution, mixed with 9 milliliters of water and 1 part of sporulated oocyst fluid of chicken coccidioides, and inoculated to chickens in the amount of 1 milliliter per chicken. The oocyst-containing fe...

Embodiment 2-1

[0053] Example 2-1: The minimum critical solution temperature of methylcellulose produced by a certain company is 58°C. Take 250 grams of the methyl cellulose and add it to 2 kg of high-temperature water at a temperature of 90°C. The suspending agent will not dissolve or agglomerate at this temperature. Kilogram temperature is the low temperature water of 15 ℃ and stirs, and this methyl cellulose dissolves rapidly within a few seconds in this high, low temperature mixed water.

Embodiment 2-2

[0054] Example 2-2: The minimum critical solution temperature of hydroxypropyl methylcellulose produced by a certain company is 60°C. Take 250 grams of this hydroxypropyl methylcellulose and add it to 3 kg of high-temperature water at a temperature of 80°C. The suspending agent will not dissolve or agglomerate at this temperature, and pour the high-temperature water containing cellulose ether Put it into 97 kilograms of low-temperature water with a temperature of 20° C. and stir it, and the hydroxypropyl methylcellulose will dissolve rapidly within a few seconds in this high-temperature and low-temperature mixed water.

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PUM

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Abstract

The invention discloses a use method for a chicken coccidiosis vaccine suspending agent and a preparation method for a suspension. The use method comprises the steps of: mixing one, two or more than two kinds of cellulose ether with lowest critical solution temperature or a mixture consisting of the cellulose ether with high-temperature water; pouring the high-temperature water containing the cellulose ether into low-temperature water and stirring; dissolving the cellulose ether or the mixture rapidly; and using the dissolved cellulose ether or mixture as the chicken coccidiosis vaccine suspension. The preparation method is as follows: adding the suspension prepared by the chicken coccidiosis vaccine suspending agent into chicken coccidiosis tetravalent living vaccine and then mixing. The use method and the preparation method have the following advantages: (1) the suspending agent disclosed by the invention can be dissolved into water rapidly; (2) the prepared suspension can keep the oocyst of the chicken coccidiosis living vaccine from settling into water within 8 hours, and the uniformity of the number of the vaccine oocyst which is driven by chicken is increased; (3) chicken flocks can be immune without cutting off water, and water cut-off stress is decreased; (4) the chicken flocks can be also immune by cutting off water, and immune time is shortened; and (5) the side effect of the vaccine can be reduced.

Description

technical field [0001] The present invention relates to a method for using a chicken coccidiosis vaccine suspending agent and a preparation method for a suspension, in particular to a method for using a suspending agent for a chicken coccidiosis live oocyst vaccine used for drinking water immunization and for its use in A method for preparing chicken coccidiosis vaccine suspension for drinking water immunization. The suspension can not only dissolve quickly; but also slow down the sinking of vaccine oocysts for up to 8 hours, and enable the chickens to be immunized without water or without water, and in both cases can reduce the vaccine side effects. Background technique [0002] Chicken coccidiosis is a kind of protozoan parasitic disease, by Eimeria tenaca, Eimeria pileosa, Eimeria giant, Eimeria poisonous, Eimeria placidum, Caused by one or more species of Eimeria brucei and Eimeria prematuria. They parasitize in various parts of the intestinal tract of chickens, causi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K39/012A61P33/02
Inventor 郝言芝
Owner 烟台青大生物制药有限公司
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