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Composite temperature-sensitive aquagel and preparation method thereof

A temperature-sensitive hydrogel and water-soluble technology, applied in chemical instruments and methods, carrier binding/immobilizing peptides, non-active components of polymer compounds, etc., can solve the problem of limiting drug inclusion effects and clinical applications, and the limitations of chemical cross-linking agents. application, poor solubility of β-cyclodextrin, etc., to achieve good research and development application prospects, wide applicability, biocompatibility and good slow-release performance

Inactive Publication Date: 2012-09-26
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that chitosan-sodium glycerophosphate (GP) system hydrogels are thermosensitive and can be used in drug controlled release systems. However, most gels have a long response time, mechanical properties need to be improved, and the use of chemical cross-linking agents also limits its practical application
Moreover, chitosan thermosensitive hydrogel has no obvious slow-release effect on small molecules and poorly water-soluble drugs, which has certain limitations in clinical application.
It has been reported that chitosan-sodium glycerophosphate temperature-sensitive system blended with β-cyclodextrin inclusion compound was used to prepare ibuprofen and chlorhexidine drug sustained-release carriers, and to study the sustained-release effect in vitro. However, due to β-cyclodextrin The poor solubility of the drug will limit the inclusion effect and clinical application of the drug

Method used

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  • Composite temperature-sensitive aquagel and preparation method thereof
  • Composite temperature-sensitive aquagel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composite temperature-sensitive hydrogel of this embodiment is made through the following steps:

[0029] (1) Copolymerize 6-deoxy-6-amino-α-cyclodextrin and carboxymethyl chitosan to obtain water-soluble 6-deoxy-6-amino-α-cyclodextrin-carboxymethyl chitosan copolymerization Add 0.20g of water-soluble 6-deoxy-6-amino-α-cyclodextrin-carboxymethyl chitosan copolymer to 20ml of distilled water, stir evenly, and prepare solution A, add 0.20g active The substance doxorubicin was stirred and dissolved, and the stirring speed was 3000rpm to obtain solution B;

[0030] (2) Dissolve 1.0 g of sodium glycerophosphate in 2 ml of distilled water, stir to dissolve, and prepare solution C;

[0031] (3) Place solution B and solution C in an ice bath and cool to 4°C, then add solution C to solution B under stirring, and stir evenly to prepare a composite temperature-sensitive hydrogel.

Embodiment 2

[0033] The composite temperature-sensitive hydrogel of this embodiment is made through the following steps:

[0034] (1) Copolymerize 6-deoxy-6-amino-β-cyclodextrin and carboxymethyl chitosan to obtain water-soluble 6-deoxy-6-amino-β-cyclodextrin-carboxymethyl chitosan copolymerization Add 2g of water-soluble 6-deoxy-6-amino-β-cyclodextrin-carboxymethyl chitosan copolymer to 20ml of distilled water, stir evenly, and prepare solution A, add 0.02g active substance to solution A Doxorubicin was stirred and dissolved, and the stirring speed was 3000rpm to prepare solution B;

[0035] (2) Dissolve 0.8g sodium glycerophosphate in 2ml distilled water, stir to dissolve, and prepare solution C;

[0036] (3) Place solution B and solution C in an ice bath and cool to 0°C, then add solution C to solution B under stirring, and stir evenly to prepare a composite temperature-sensitive hydrogel.

Embodiment 3

[0038] The composite temperature-sensitive hydrogel of this embodiment is made through the following steps:

[0039] (1) Copolymerize 6-deoxy-6-amino-β-cyclodextrin and carboxypropyl chitosan to obtain water-soluble 6-deoxy-6-amino-β-cyclodextrin-carboxypropyl chitosan copolymerization Add 1.0g of water-soluble 6-deoxy-6-amino-β-cyclodextrin-carboxypropyl chitosan copolymer to 20ml of distilled water, stir evenly, and prepare solution A, add 0.10g active The substance mercaptopurine was stirred and dissolved, and the stirring speed was 3000rpm to obtain solution B;

[0040] (2) Dissolve 3.0 g of sodium glycerophosphate in 5 ml of distilled water, stir to dissolve, and prepare solution C;

[0041] (3) Place solution B and solution C in an ice bath and cool to 0°C, then add solution C to solution B under stirring, and stir evenly to prepare a composite temperature-sensitive hydrogel.

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Abstract

The invention relates to the technical field of high molecular materials, and particularly discloses a composite temperature-sensitive aquagel and a preparation method thereof. The preparation method of the composite temperature-sensitive aquagel comprises the following steps: copolymerizing 6-desoxy-6-amino-cyclodextrin with chitosan carboxyl derivatives to obtain a water-soluble cyclodextrin-chitosan derivative copolymer, dissolving the water-soluble cyclodextrin-chitosan derivative copolymer in water to prepare a solution A, adding active substances into the solution A, and dissolving by stirring to obtain a solution B; dissolving glycerophosphate sodium in water to prepare a solution C; and cooling the solution B and the solution C, and adding the solution C into the solution B under stirring conditions, thereby obtaining the composite temperature-sensitive aquagel. The composite temperature-sensitive aquagel disclosed by the invention has the advantages of favorable temperature sensitivity, favorable biocompatibility and good slow release performance; and the preparation method has the advantages of stable technique, wide raw material sources and low manufacturing cost, and is simple to operate.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a composite temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Cyclodextrin (CD) is an oligomeric cyclic compound connected by α-1,4-glycosidic bonds. It has a unique internal hydrophobic and external hydrophilic structure. It is a commonly used pharmaceutical excipient and has good biophase Compatibility, can form clathrates with various organic substances, and is currently used in the fields of oral administration preparations, topical administration preparations, traditional Chinese medicine preparations and nanoparticle drug delivery systems. However, the solubility of β-cyclodextrin in water is very low, and the clathrate formed is almost insoluble, and its solubility can be improved by forming a copolymer. [0003] Temperature-sensitive in-situ gel drug delivery system has become a research hotspot in the field of pharm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/16C08L5/08C08G81/00C08B37/08C08B37/16A61K47/40C07K17/10C12N11/10
Inventor 周惠云张延萍姜凌娟周冬菊冯素香
Owner HENAN UNIV OF SCI & TECH
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