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Preparation containing ligustilide type component for treating cardio-cerebrovascular disease and preparation method thereof

A technique for cardiovascular and cerebrovascular diseases and yangchuanxiongolide, which is applied in the field of extracting chuanxiongolide components and their preparation, can solve problems such as poor quality controllability of active ingredients, achieve good economic and social benefits, maintain stability, Easy-to-save effects

Inactive Publication Date: 2012-08-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems in the prior art, the present invention provides a chuanxiong lactone component preparation and its preparation method, which solves the problem of poor quality controllability of the active ingredients in the preparation and extraction of chuanxiong medicinal materials in the prior art

Method used

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  • Preparation containing ligustilide type component for treating cardio-cerebrovascular disease and preparation method thereof
  • Preparation containing ligustilide type component for treating cardio-cerebrovascular disease and preparation method thereof
  • Preparation containing ligustilide type component for treating cardio-cerebrovascular disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Preparation of sublingual lozenges for the treatment of cardiovascular and cerebrovascular diseases by Chuanxiong lactone components

[0032] (1) Preparation of effective parts of chuanxiong lactones

[0033] Take 10Kg of Rhizoma Chuanxiong medicinal material (origin: Guan County, Sichuan Province) and crush it, pass through a 20-mesh sieve, and place it in a supercritical fluid extraction apparatus for extraction. Kettle I has a temperature of 40°C and a pressure of 7MPa, and a separation kettle II has a temperature of 30°C and a pressure of 6MPa. The extracts from the combined separation kettles I and II are the effective parts of Ligusticum lactone.

[0034] (2) Preparation of β-cyclodextrin inclusion compound

[0035] Weigh 80g of β-cyclodextrin and add it into water at 30°C to make a saturated solution. Slowly drop 10g of Rhizoma Chuanxiong volatile oil (diluted with an equal amount of absolute ethanol) into the saturated solution of β-cyclodextrin, sti...

Embodiment 2

[0038] Embodiment 2. Preparation of dripping pills for the treatment of cardiovascular and cerebrovascular diseases by Chuanxiong lactone components

[0039] (1) Preparation of effective parts of chuanxiong lactones

[0040] Take 10Kg of Rhizoma Chuanxiong medicinal material (origin: Guan County, Sichuan Province) and crush it, pass through a 20-mesh sieve, and place it in a supercritical fluid extraction apparatus for extraction. The temperature of kettle I is 50°C, the pressure is 7MPa, the temperature of separation kettle II is 40°C, the pressure is 6MPa, and the entrainer is 2% absolute ethanol. The extracts in the two separation kettles are combined, the obtained product is evaporated to remove ethanol, and the residual water is removed with anhydrous sodium sulfate to obtain the effective part of Ligusticum lactone.

[0041] (2) Preparation of dropping pills

[0042] Take 50g of polyethylene glycol 6000 and heat it until it is completely melted, then add 8g of the effe...

Embodiment 3

[0044] (1) Preparation of effective parts of chuanxiong lactone components and β-cyclodextrin inclusion compound reference example 1.

[0045] (2) Preparation of sublingual lozenges

[0046] Take 60g of the above-mentioned β-cyclodextrin inclusion compound, add 80g of starch, 40g of dextrin, 20g of powdered sugar, 10g of glutathione, an appropriate amount of 17% starch slurry, 10g of povidone (PVP), 2g of magnesium stearate, Stearic acid 3g, made sublingual lozenge 1000 according to conventional technology, vested.

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Abstract

The invention discloses a preparation containing a ligustilide type component and a preparation method thereof. The ligustilide type component comprises the following components by weight percent: ligustilide 14%-42%, sedanolide 3%-20%, butylidenephthalide 0.1%-5%, butylphthalide 0.1%-3%, senkyunolide-H 0.2%-3%, senkyunolide-I 0.4%-5%, levistilide A 0.5%-1.5%, and riligustilide 0.4%-1.2%. The preparation method prevents the ligustilide type component from being destroyed by the wet distillation method and the solvent extraction method, and the quality of the ligustilide type component is more ensured without solvent residue. The preparation containing the ligustilide type component is safe and controllable on the effective part. Drop pills and sublingual tablets containing the ligustilide type component can avoid the defects of the oral preparation after administration such as liver first pass effect and gastrointestinal reaction, and an injection containing the ligustilide type component can also avoid the possible situations during using the injections such as acute poisoning reaction and allergic reaction. The preparation containing the ligustilide type component is safer and more effective, and has good economic benefit and social benefit.

Description

technical field [0001] The invention relates to a traditional Chinese medicine active ingredient preparation and a preparation method thereof, in particular to a method for extracting chuanxiong lactone components from Ligusticum chuanxiong by using a supercritical fluid method and a preparation process thereof. Background technique [0002] The traditional Chinese medicine Chuanxiong is the dried rhizome of Ligusticum chuanxiong in the Umbelliferae family. Its main functions are to promote blood circulation and Qi, dispel wind and relieve pain. , headache, and rheumatic arthralgia are commonly used traditional Chinese medicines in traditional Chinese medicine prescriptions, and are also important raw materials for many Chinese patent medicines. Since 1977, Beijing Institute of Pharmaceutical Sciences published "Research on the Active Components of Chuanxiong" in the 7th issue of "Chinese Medical Journal", naming tetramethylpyrazine as "TMP", its pharmacological research has...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61P9/10
Inventor 杨学东胡立翠伍勋
Owner TIANJIN UNIV
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