Metoprolol slow-release tablet and preparation method thereof
A torolol sustained-release tablet and torolol tablet technology, which are applied in the field of medicine, can solve the problems of drug burst release, reduce the efficacy of metoprolol, and the drug cannot be released stably, so as to avoid drug burst release and reduce The effect of the degree of fragmentation
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Embodiment 1
[0046] Embodiment 1: Preparation of metoprolol sustained-release tablet of the present invention
[0047] 1. Formula
[0048] See Table 1.
[0049] Table 1 Formulation
[0050]
[0051] 2. Preparation method
[0052] To prepare medicated pellets:
[0053] Dissolve the prescribed amount of HPMC E5 and metoprolol succinate in water, add microcrystalline cellulose PH-F20JP and crystalline cellulose to the solution under stirring to disperse them, and set aside.
[0054] Weigh the prescribed amount of sucrose pellets and place them in the fluidized bed. After starting the instrument and setting the experimental parameters, after the temperature of the material reaches the set material temperature, spray the liquid with the bottom spray method. The experimental parameters are: the diameter of the nozzle is 0.5mm, the air inlet temperature is 55-60°C, the material temperature is 30-45°C, and the atomization pressure is 0.15-0.20MPa.
[0055] Package isolation layer:
[0056...
Embodiment 2
[0069] Embodiment 2: Preparation of metoprolol sustained-release tablet of the present invention
[0070] 1. Formula
[0071] See Table 2.
[0072] Table 2 Formulation
[0073]
[0074]
[0075] 2. Preparation method
[0076] To prepare medicated pellets:
[0077] Take an appropriate amount of water in a beaker, heat it to 70-80°C, add the prescribed amount of HPMC E5 into the water and stir to disperse it. After cooling down, wait until HPMC E5 is completely dissolved, add metoprolol succinate, microcrystalline cellulose PH101 and HPMC K4M according to the prescription amount in the table, mix well and place in a wet granulator, set the speed of the stirring paddle at 200-250 rpm The speed of the cutting knife is 2000-3000 rpm, and after dry mixing, an appropriate amount of purified water is gradually added to make a soft material.
[0078] The prepared soft material was transferred to an extruder and extruded into strips with a diameter of 0.4 mm, and the screw sp...
Embodiment 3
[0093] Embodiment 3: Preparation of metoprolol sustained-release tablet of the present invention
[0094] 1. Formula
[0095] See Table 3.
[0096] Table 3 Formulation
[0097]
[0098]
[0099] 2. Preparation method
[0100] To prepare medicated pellets:
[0101] Dissolve the prescribed amount of HPMC E5 and metoprolol succinate in water, add microcrystalline cellulose PH-F20JP and crystalline cellulose to the solution under stirring to disperse them, and set aside.
[0102] Weigh the prescribed amount of microcrystalline cellulose pellets and place them in the fluidized bed. After starting the instrument and setting the experimental parameters, after the material temperature reaches the set material temperature, spray the liquid and apply the medicine by bottom spraying. The experimental parameters are: the diameter of the nozzle is 0.5mm, the air inlet temperature is 55-60°C, the material temperature is 30-45°C, and the atomization pressure is 0.15-0.20MPa.
[0103...
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