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Preparation method of natural polyelectrolyte-based core-shell structured nano-fiber

A polyelectrolyte, nanofiber technology, applied in the direction of chemical characteristics of fibers, pharmaceutical formulations, conjugated synthetic polymer man-made filaments, etc., to achieve the effect of a simple method

Inactive Publication Date: 2012-07-25
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the preparation of polyelectrolyte-based core-shell nanostructures by using an electric field to control the phase separation of electrospinning solution components.

Method used

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  • Preparation method of natural polyelectrolyte-based core-shell structured nano-fiber
  • Preparation method of natural polyelectrolyte-based core-shell structured nano-fiber
  • Preparation method of natural polyelectrolyte-based core-shell structured nano-fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Dissolving hyaluronic acid with a molecular weight of 5000g / mol in water to prepare a solution with a weight percentage of 10wt%, and then fully stirring the solution so as to completely dissolve to obtain a hyaluronic acid solution.

[0024] (2) Dissolving polyoxyethylene in water to prepare a solution with a weight percentage of 4wt%, and then fully stirring the solution so as to completely dissolve to obtain a polyoxyethylene solution. The hyaluronic acid solution and the polyoxyethylene solution are mixed according to a volume ratio of 1:1 to obtain an electrospinning solution.

[0025] (3) Add the electrospinning solution prepared in step (2) into the solution supply device, adjust the voltage to 30kV; the distance from the spinneret to the collecting plate is 20cm; the flow rate of the spinneret spinning solution is 1mL / h. Start the device for electrospinning, and obtain hyaluronic acid / polyoxyethylene core-shell structure nanofibers on the collecting plate, w...

Embodiment 2

[0027] (5) The hyaluronic acid / polyoxyethylene core-shell structure nanofibrous membrane obtained in step (3) was subjected to a cell inoculation experiment, and it had excellent cell attachment and proliferation characteristics. Embodiment 2: (1) dissolving chitosan with a molecular weight of 3000g / mol in water is prepared into a solution of 5wt% by weight, and then the solution is fully stirred so that it is completely dissolved to obtain a chitosan solution.

[0028] (2) Dissolving polyvinyl alcohol in water to prepare a solution with a weight percentage of 10 wt%, and then fully stirring the solution so that it is completely dissolved to obtain a polyvinyl alcohol solution. The chitosan solution and the polyvinyl alcohol solution are mixed at a volume ratio of 5:1 to obtain an electrospinning solution.

[0029] (3) Add the electrospinning solution prepared in step (2) into the solution supply device, adjust the voltage to 25kV; the distance from the spinneret to the collec...

Embodiment 3

[0032] Example 3: (1) Dissolve hyaluronic acid with a molecular weight of 2 000 000 g / mol in water to prepare a solution with a weight percentage of 1 wt%, and then stir the solution fully so that it is completely dissolved to obtain a hyaluronic acid solution.

[0033] (2) Dissolving polyvinylpyrrolidone in water to prepare a solution with a weight percentage of 10wt%, and then fully stirring the solution so that it is completely dissolved to obtain a polyvinylpyrrolidone solution. The hyaluronic acid solution and the polyvinylpyrrolidone solution are mixed at a volume ratio of 9:1 to obtain an electrospinning solution.

[0034] (3) Add the electrospinning solution prepared in step (2) into the solution supply device, adjust the voltage to be -30kV; the distance from the spinneret to the collecting plate is 8cm; the flow rate of the spinneret spinning solution is 0.5mL / h. Start the device for electrospinning, and obtain hyaluronic acid / polyvinylpyrrolidone core-shell struct...

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Abstract

The invention provides a preparation method of natural polyelectrolyte-based core-shell structured nano-fiber. According to the invention, natural products of hyaluronic acid, sodium polymannuronate, heparin, gamma-polyglutamic acid, chitosan, and epsilon-polylysine, and synthesized polymers of polyoxyethylene, polyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol and polycaprolactone are adopted as raw materials; a soluble composite solution of the materials are prepared; and the natural polyelectrolyte-based core-shell structured nano-fiber is prepared with a high-pressure electrospinning technology. According to the invention, polyelectrolyte and synthesized polymers are separated through the induction of electric fields, such that the core-shell structured nano-fiber is successfully prepared. The nano-fiber prepared by the invention has special potential application in respects such as bioactive compound or medicine packaging, chemical modification, cell stents, medicine releasing, and gene transferring.

Description

technical field [0001] The invention belongs to the field of preparation of biopolymer composite nanofiber materials, and relates to a preparation method of polyelectrolyte-based core-shell structure nanofibers. Background technique [0002] Electrospinning is a processing method that injects charged polymer solution or melt in an electrostatic field to prepare polymer ultrafine fibers. When the applied electric field reaches a certain critical value, the fiber will be ejected from the spinneret At the same time, the solvent gradually evaporates away from the charged fibers, and the dried fibers fall on the collecting plate to form ultra-fine nanofiber non-woven fabrics. The prepared nanofiber non-woven fabric has the advantages of large specific surface area, high porosity, fineness and uniformity of fibers, and large aspect ratio, making it suitable for biological tissue engineering, wound repair, skin burns and postoperative anti-adhesion, etc. Biomedical materials and o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/18D01F8/16D01F8/10D01F8/14D01F8/12A61K47/32A61K47/34A61K47/36A61L27/26A61L27/50
Inventor 马贵平聂俊刘洋王志亮
Owner BEIJING UNIV OF CHEM TECH
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