Traditional Chinese medicine for preventing and curing recurrent aphthae and preparing method thereof
A technology of traditional Chinese medicine and components, applied in the field of medical engineering, can solve the problems of recurrent aphthous ulcers that cannot be cured, strong irritation of the digestive tract, and poor pertinence, and achieve high-efficiency prevention and treatment, no drug resistance, and low price Effect
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preparation example Construction
[0058] The present invention also provides a preparation method of a traditional Chinese medicine for preventing and treating recurrent aphthous sores. When the dosage form of the traditional Chinese medicine is a capsule, it includes:
[0059] In the first step, the components are mixed in proportion, and ethanol with an alcohol concentration of 80% to 90% is added for heating and reflux extraction for 2 to 4 times. The obtained extracts are combined, filtered, and concentrated under reduced pressure to remove 80% by mass. ~90% ethanol to obtain a concentrated solution, the mass of ethanol added is 2~4 times the mass of the mixture;
[0060] In the second step, the above concentrated solution is passed through a macroporous adsorption resin column, first eluted with 3 to 5 times the volume of the resin column deionized water or distilled water, and then 2 to 4 times the volume of the resin column with an alcohol concentration of 90%-95% Ethanol elution, collect ethanol eluate, con...
Embodiment 1
[0074] Example 1 Toxicity test of the traditional Chinese medicine of the present invention
[0075] Experimental drug
[0076] South Ginseng 23g, Evodia 15g, Cinnamon 9g, Qianghuo 14g, Aloe 32g, Indigo Naturalis 38g, Gallnut 15g, Dogwood 22g, Cistanche 18g, Oldenlandia diffusa 25g, Sophora flavescens 25g, Polygala 12g, Ebony 22g, Coptis 68g, Plantain 20g of senna, 16g of senna, 15g of puerariae, 25g of medlar, 35g of rehmannia, 32g of peony bark, 28g of licorice and 25g of Atractylodes macrocephala, mixed with 1600g of ethanol with 90% alcohol concentration and refluxed for 3 times, and the obtained extract Combine, filter, concentrate under reduced pressure to remove 80% of the mass percentage of ethanol to obtain a concentrated solution. The concentrated solution is passed through a 6LAB-8 type macroporous adsorption resin column, first eluted with 4 times the volume of the resin column of deionized water, and then used The alcohol concentration of 4 times the volume of the res...
Embodiment 2
[0079] Example 2 Preparation of capsules
[0080] South Ginseng 23g, Evodia 15g, Cinnamon 9g, Qianghuo 14g, Aloe 32g, Indigo Naturalis 38g, Gallnut 15g, Dogwood 22g, Cistanche 18g, Oldenlandia diffusa 25g, Sophora flavescens 25g, Polygala 12g, Ebony 22g, Coptis 68g, Plantain 20g of senna, 16g of senna, 15g of puerariae, 25g of medlar, 35g of rehmannia, 32g of peony bark, 28g of licorice and 25g of Atractylodes macrocephala, mixed with 1600g of ethanol with 90% alcohol concentration and refluxed for 3 times, and the obtained extract Combine, filter, concentrate under reduced pressure to remove 80% of the mass percentage of ethanol to obtain a concentrated solution. The concentrated solution is passed through a 6LAB-8 type macroporous adsorption resin column, first eluted with 4 times the volume of the resin column of deionized water, and then used The alcohol concentration of 4 times the volume of the resin column is 95% ethanol elution. Collect the ethanol eluate, concentrate it ...
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