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Venenum bufonis powder injection for cardiotonic emergency treatment and preparation method thereof

A technology for injection and toad venom, which is applied in the field of toad venom powder injection and preparation thereof, can solve the problems of poor stability of liquid toad venom preparation, vascular irritant effect, easy deterioration and failure, etc., and achieves avoiding first-pass effect, not easy to deteriorate, failure and shortening. The effect of onset time

Active Publication Date: 2013-10-16
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the toad venom preparation is insoluble in water and highly toxic, it will stimulate blood vessels. At present, it is mostly administered orally, but it is still difficult to avoid the disadvantages of low efficacy and side effects, and the stability of the liquid toad venom preparation is not good. , easy to deteriorate and fail

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] ①Take 15 grams of toad venom that meets the requirements of the Pharmacopoeia, grind it, wash it with water to remove impurities, pass it through a 20-mesh sieve, and mix it for later use;

[0035] ② Add 3 times the amount of 95% ethanol to the toad venom treated in the above steps, heat and reflux for 20 hours, repeat twice, combine the obtained extracts, concentrate and evaporate to dry to make toad venom extract;

[0036] ③ Dissolve the extract of toadseye prepared in step 2 in physiological saline containing 1.5% poloxamer 188, add sodium sulfate with a concentration of 0.4mol / ml to make the final concentration 60mmol / ml, and obtain a solution of toadseye;

[0037] 4. Weigh 8 grams of chitosan powder, dissolve in double distilled water, emulsify and mix at high speed, and prepare a chitosan emulsion with a mass fraction of 1.5%, and add acetic acid to adjust the pH value to 5.2;

[0038] 5. Mix the toad venom solution obtained in step 3 with the chitosan emulsion ob...

Embodiment 2

[0041] ①Take 15 grams of toad venom that meets the requirements of the Pharmacopoeia, grind it, wash it with water to remove impurities, pass it through a 20-mesh sieve, and mix it for later use;

[0042] ② Add 3 times the amount of 95% ethanol to the toad venom treated in the above steps, heat and reflux for 20 hours, repeat twice, combine the obtained extracts, concentrate and evaporate to dry to make toad venom extract;

[0043] ③ Dissolving the extract of toad venom prepared in step 2 in physiological saline containing 1.2% poloxamer 188, adding sodium sulfate with a concentration of 0.4 mol / ml to make the final concentration 40 mmol / ml to obtain a solution of toad venom;

[0044] ④ Take 15 grams of aluminum nitrate, add double distilled water to dissolve, prepare a saturated solution, and filter out insoluble matter

[0045] ⑤ Add ammonia water dropwise to the above solution and stir slowly, stop adding after the white flocculent precipitate no longer increases, and let i...

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Abstract

The invention relates to venenum bufonis powder injection for cardiotonic emergency treatment. The venenum bufonis powder injection consists of venenum bufonis powder and a pharmaceutically acceptable carrier in a weight ratio of (1:1)-(4:1), wherein the carrier is chitosan or aluminium hydroxide; and the powder size of the venenum bufonis powder injection is between 10 and 120 microns. The venenum bufonis powder injection is particularly applicable to a needle-free injection technology. The invention also relates to a preparation method for the venenum bufonis powder injection.

Description

technical field [0001] The invention relates to a toad venom powder injection for cardiotonic first aid and a preparation method thereof, and in particular to a toad venom powder injection suitable for a needle-free injection technique and a preparation method thereof. Background technique [0002] Toad Su is a white slurry secreted by Bufo Bufo Bufo or Bufo Black Orbital glands behind the ears and skin glands. It is processed and dried. The main function is to detoxify, reduce swelling, strengthen the heart, and relieve pain. It is clinically used for carbuncle furuncle, sore throat, fever and abdominal pain embolism. Modern research shows that toad venom is a mixture of various cardiotonic steroid compounds, mainly containing bufolides, bufotryptamines, sterols and other components. The main medicinal ingredients are bufogenin and bufotoxin. The cardiotonic effects of bufogenin and bufotoxin are mainly manifested in enhancing myocardial contractility, increasing cardiac ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K35/65
Inventor 王伽伯肖小河王喆桅金城李奇
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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