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Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, antipyretics, etc., can solve the problems of affecting the absorption and utilization of active ingredients of drugs, slow release of active ingredients, and long healing period, so as to achieve improved compliance, drug The effect of stable active components and high bioavailability

Active Publication Date: 2013-08-28
JINKE TIBETAN MEDICINE QINGHAI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the preparation methods of ruyizhenbao medicines all adopt the simple physical treatment of pulverizing and mixing the raw materials. Although the biological activity of the original medicine is retained, it is easy to cause dissolution, slow disintegration, and slow release of active ingredients. Affect the absorption and utilization of the active ingredients of the drug, resulting in slow onset and long healing period

Method used

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  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof
  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof
  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0040] Experimental Example 1. Analgesic effect of the pharmaceutical composition preparation of the present invention (prepared in Example 1)

[0041] 1 Test material

[0042] 1.1 Experimental animals

[0043] Kunming mice, male, 19-22g, laboratory animal center of Shandong Natural Medicine Engineering Technology Research Center, certificate number: SYXK (Lu) 20030020.

[0044] 1.2 Test drugs and reagents

[0045] Tested drug: Ruyi Zhenbao Pill, specification 0.5g / pill, batch number: 20100918, provided by Qinghai Jinhe Tibetan Medicine Co., Ltd. The capsule preparation of the pharmaceutical composition of the present invention, batch number: 20110110, provided by Shandong Arula Pharmaceutical Research and Development Co., Ltd.

[0046] Positive control drug: indomethacin, specification 25mg / tablet, batch number: A100802, commercially available.

[0047] Reagent: acetic acid, Shandong Chemical Industry Research Institute, batch number: 980610; CMC-Na, Shanghai Wanbang Chem...

experiment example 2

[0064] Experimental Example 2, the anti-gout effect of the pharmaceutical composition preparation of the present invention (prepared in Example 1)

[0065] 1 Test material

[0066] 1.1 Experimental animals

[0067] SD rats, male, weighing 190-240 g. Provided by the Laboratory Animal Center of Shandong University of Traditional Chinese Medicine, certificate number: SCXK (Lu) 20050015.

[0068] 1.2 Test drugs and reagents

[0069] Tested drug: capsule preparation of the pharmaceutical composition of the present invention, batch number: 20110110, provided by Shandong Arula Pharmaceutical Research and Development Co., Ltd.

[0070] Positive control drug: indomethacin, specification 25mg / tablet, batch number: A100802, commercially available.

[0071] Reagents: uric acid, purchased from Sigma, batch number: U2625; Tween 80, Shandong Institute of Chemistry, batch number: 080612; physiological saline, Shandong Qidu Pharmaceutical Co., Ltd., batch number: 3B10102305; Chloral hydrat...

Embodiment 1

[0098] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Example 1 The pharmaceutical composition capsule of the present invention

[0099] Composition of API:

[0100]

[0101] (1) Extraction and inclusion of volatile oil: take 100g of agarwood, 40g of cloves, 40g of nutmeg, 40g of cardamom, 30g of grass fruit, 40g of celery, 80g of sandalwood, 40g of Nigella sativa, 330g of Fructus cuspidatum, 30g of longan, 80g of galangal, 50g of cinnamon, 80g of woodsy, and 80g of cinnamon, add 6 times by weight of water, extract volatile oil by steam distillation, extract for 4h, collect volatile oil to obtain 25ml of volatile oil, filter the medicinal solution, and obtain the medicine Liquid A and medicinal residue A, medicinal liquid A is concentrated to the fluid extract A with a relative density of 1.12 under the condition of 60 ° C; : 4g ratio, under stirring conditions, add the volatile oil to the β-cyclodextrin aqueous solution with a weight volume ratio of 4%, the temperature...

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Abstract

The invention discloses a Ruyizhenbao medicine composite, which is prepared by adopting the following steps of essential oil extraction and inclusion, ethanol extraction, water extraction, fluid extract drying, medicinal material fine powder crushing, expensive and fine medicine fine powder preparation and the like. Pharmaceutically conventional auxiliary materials are added according to a conventional process to be prepared into clinically acceptable dosage forms such as: powders, capsules, tablets, oral liquid, condensed pills, granular formulations, pills, pellets and slow release preparations. The invention is characterized in that the Ruyizhenbao composite is prepared by taking phytochemical components as the material base and the pharmacodynamics activity as the guidance by adoptinga modern extraction preparation method. The medicinal preparation prepared by the method disclosed by the method has the advantages of high absorption rate, stable pharmacodynamic components, high bioavailability and the like under the condition that the pesticide effects of the raw preparation are remained.

Description

technical field [0001] The invention relates to a preparation of a pharmaceutical composition and a preparation method thereof, in particular to a preparation method of a pharmaceutical preparation for treating stroke sequelae, white vein disease, gout and joint unfavorable conditions. technical background: [0002] Ruyi Zhenbao Pill, Tibetan medicine name: Sangpei Nubu Ribu; it is recorded in the Tibetan medicine classic book "Supplement to Tibetan Medicine" in the 15th century AD. In the 17th century AD, the book "Pande Qiongnai" edited by Situ Quejiqiongnai, a famous Tibetan medical scientist, recorded the formula and functions of this prescription, and it is still in use today. It is now included in the first volume of "Medical Standards of the Ministry of Health of the People's Republic of China: Tibetan Medicine", the standard number is WS3-BC-0314-95. [0003] The prescription is mainly composed of 30 kinds of medicinal materials such as mother of pearl, agarwood, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/10A61K36/9064A61P19/02A61P19/06A61P29/00A61K31/122A61K33/06A61K35/32A61K35/413A61K35/56A61K35/612A61K35/618
Inventor 马振元邵成雷李丽李怀平孙绪丁刘玉芹
Owner JINKE TIBETAN MEDICINE QINGHAI PROV
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