Salted fructus alpiniae oxyphyllae formula particle and preparation method thereof

Abstract

The invention belongs to the field of extraction and preparation of traditional Chinese medicines, and particularly relates to a salted fructus alpiniae oxyphyllae formula particle and a preparation method thereof, aiming at providing a salted fructus alpiniae oxyphyllae formula particle with an obvious curative effect of the product and convenient administration. The preparation method comprises the following steps of: removing shells of alpinia oxyphylla medicines, adding saline solution for complete moistening, frying to be dried and obtaining salted fructus alpiniae oxyphyllae; crushing the salted fructus alpiniae oxyphyllae into rough powder, adopting supercritical carbon dioxide extraction to obtain volatile oil and medicine dregs for spare; clathrating the volatile oil with beta-cyclodextrin to obtain volatile oil-beta-cyclodextrin clathrate compound; decocting the medicine dregs with water to obtain decocted liquid, filtering, concentrating into extract, adding auxiliary materials with the amount being 15-25% of that of the extract, spraying, drying and obtaining extract powder; and adding the clathrate compound into the extract powder, carrying out dry-process granulation and obtaining the particle. The invention has the advantages that the strict standard is formulated in the aspects of shell removing process, the salting process, the quality of the raw medicine pieces and the like, and in the aspect of the pharmacological and pharmacodynamic test, the obvious effect of urine reduction of the product is ensured; and simultaneously the cost is low, the storage is easy, the carrying and the administration are convenient and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction and preparation, and in particular relates to salt-yizhiren formula granules and a preparation method thereof. Background technique [0002] Nootropic kernels are nootropic Alpinia oxyphylla The dried ripe fruit of Miq. is a traditional Chinese medicine commonly used in clinical practice. Yizhi Rensheng products are pungent, warm and dry, and they are mainly returned to the spleen meridian. They are used to warm the spleen and stop diarrhea, and absorb saliva. It is often used for abdominal pain, vomiting and diarrhea, and salivary flow due to spleen and stomach deficiency. Saliva can relieve dryness after salt roasting Its nature, mainly returns to the kidney meridian, specializes in the lower energizer, is better than solidifying essence and reducing urination, and is mostly used to treat seminal emission, premature ejaculation, frequent urination, enuresis, white turbidi...

AI Technical Summary

Problems solved by technology

[0005]1. The shelling process of traditional nootropic medicinal materials is cumbersome and time-consuming

[0006]The traditional way of shelling the nuts is to manually crush and remove the shells, or to crush and remove the shells in a groove, or fry the nuts until the surface bulges. Then crush it with a flattening machine, and then remove the shell by winnowing. This method is labor-intensive and time-consuming, and the yield of Yizhi kernel is not high, so it is not suitable for large-scale production.

[0007]2. The quality of Yanyizhiren formula granules cannot be guaranteed from the source

At present, there are no legal standards for the processing technology and quality control of Yanyizhiren

In the 2010 edition of the Chinese Pharmacopoeia, the salt-burning process of Yizhi kernels is "taking Yizhi kernels and frying them with salt water". There are no specific process parameters, and the quality control of medicinal materials is still only based on the volatile oil content. It is difficult to guarantee and control the salt and Yizhi The quality of kernel decoction pieces cannot guarantee the quality of formula granules from the source

[0009]3. The extraction rate of volatile oil from Yanyi Zhiren is not high

[0010]The traditional extraction process of Yanyizhiren usually uses steam distillation to extract the volatile oil, and the dregs are decocted with water to extract the remaining components. The extraction rate of volatile oil is not high, and it is easy to Adhesion to the wall of the device and loss, thus affecting product quality and clinical efficacy

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