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Novel notriterpenoid saponin compound and preparation method and application thereof

A compound, nortriterpene technology, applied in the field of preparation of antineoplastic drugs and new saponins

Active Publication Date: 2012-04-11
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] North American Salicornia has no pharmacological activity reports, but it belongs to the same relative species and has medicinal value

Method used

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  • Novel notriterpenoid saponin compound and preparation method and application thereof
  • Novel notriterpenoid saponin compound and preparation method and application thereof
  • Novel notriterpenoid saponin compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 30Kg of the whole herb of Salicornia chinensis was extracted three times with 90% ethanol under reflux, the dosage was 200 liters, each time for 3 days, concentrated and combined into a concentrated solution without alcohol smell to obtain the total extract. Then sequentially extracted with petroleum ether, ethyl acetate, n-butanol. The n-butanol extract was separated by column chromatography to obtain 3 grams of salicornia saponin A. (see attached Figure 9 )

Embodiment 2

[0044]10Kg of the whole herb of Salicornia chinensis, extracted three times by heating with water, the amount of water used is 20 liters, the extraction time is 1 hour, the extraction temperature is 70°C, and the extract is absorbed by macroporous resin (D101, AB-8, HP-20, etc.) , washed with water and 30% ethanol and then eluted with 70% ethanol, and the 70% ethanol eluate was recovered under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.8 g of salicordin A, respectively.

Embodiment 3

[0046] 10Kg of the whole plant of Salicornia chinensis, extracted three times by cold immersion in methanol, the amount of methanol used is 20 liters, the extraction time is 1 day, and the extract is absorbed by macroporous resin (D101, AB-8, HP-20, etc.). Wash with water and 30% ethanol and then elute with 70% ethanol, and recover the solvent from the 70% ethanol eluate under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.9 g of salicordin A, respectively.

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PUM

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Abstract

The invention discloses a novel notriterpenoid saponin compound and a preparation method and application thereof, belonging to the field of natural pharmaceutical chemistry. The method is characterized in that: a novel notriterpenoid compound is obtained through extraction, separation and purification from salicornia bigelovii torr by using a chemical method of water or organic solvent, and is named salicornia bigelovii torr macranthoidin. The compound can inhibit the proliferation of tumor cell in vitro, demonstrating that the salicornia bigelovii torr macranthoidin has a new application of preparing an antitumor drug in the medical field.

Description

1. Technical field: [0001] The invention relates to the field of natural medicines, in particular to a new saponin extracted and separated from Salicornia saponica, its preparation method, and the antitumor activity of the new saponin and its use in the preparation of antitumor drugs. 2. Technical background: [0002] Salicornia bigelovii Torr., also known as Salicornia bigelovii Torr., belongs to the genus Salicornia L. of Chenopodiaceae, and can be directly irrigated with seawater. The cultivation of Salicornia is beneficial to improving the ecological environment, constructing ecological wetlands, and providing food and habitat for wild birds. [0003] At the same time, Salicornia has a variety of comprehensive utilization methods. The oil content of its seeds is about 30%, and the unsaturated fatty acid content is as high as 90%. 40 times that of vegetables, and can be used as raw materials for green organic vegetables, health food, health oil, etc. [0004] North Amer...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08A61K31/704A61P35/00
Inventor 单宇冯煦王奇志管福琴王鸣陈雨印敏赵友谊孙浩
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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