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A new salicornia nortriterpenoid saponin compound and its preparation method and application

A technology of triterpenoid saponins and compounds, applied in the field of new saponins, preparation of anti-tumor and anti-inflammatory drugs

Active Publication Date: 2015-09-16
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] North American Salicornia has no pharmacological activity reports, but it belongs to the same relative species and has medicinal value

Method used

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  • A new salicornia nortriterpenoid saponin compound and its preparation method and application
  • A new salicornia nortriterpenoid saponin compound and its preparation method and application
  • A new salicornia nortriterpenoid saponin compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 30Kg of the whole herb of Salicornia chinensis was extracted three times with 80% ethanol under reflux, the dosage was 200 liters, each time for 3 days, concentrated and combined into a concentrated solution without alcohol smell to obtain the total extract. Then sequentially extracted with petroleum ether, ethyl acetate, n-butanol. The n-butanol extract was separated by column chromatography to obtain 2.4 g of salicordin B. (see attached Figure 9 )

Embodiment 2

[0059] 10Kg of the whole herb of Salicornia chinensis, heated and extracted three times with water, the water consumption is 20 liters, the extraction time is 2 hours, the extraction temperature is 80°C, and the extract is absorbed by macroporous resin (D101, AB-8, HP-20, etc.) , washed with water and 30% ethanol and then eluted with 50% ethanol, and the 50% ethanol eluate was recovered under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.8 g of salicordin B, respectively.

Embodiment 3

[0061] 10Kg of the whole plant of Salicornia chinensis, extracted three times by cold immersion in methanol, the amount of methanol used is 20 liters, the extraction time is 1 day, and the extract is absorbed by macroporous resin (D101, AB-8, HP-20, etc.). Wash with water and 30% ethanol and then elute with 50% ethanol, and recover the solvent from the 50% ethanol eluent under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.7 g of salicordin B, respectively.

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Abstract

The present invention relates to a new nortriterpenoid saponin compound, a preparation method and uses thereof, and belongs to the field of natural pharmaceutical chemistry, wherein a chemical method adopting water or an organic solvent is adopted to extract, separate and purify the whole plant of salicornia bigelovii torr to obtain a new nortriterpenoid compound, which is named salicornia bigelovii torr saponin B. The present invention further provides a preparation method for the compound and uses of the compound in the medicine field, particularly in preparation of anti-tumor and anti-inflammation drugs.

Description

1. Technical field: [0001] The invention relates to the field of natural medicines, in particular to a new saponin extracted and separated from Salicornia saponica, a preparation method thereof, and the anti-tumor and anti-inflammatory activities of the new saponin and its use in the preparation of anti-tumor and anti-inflammatory drugs. 2. Technical background: [0002] Salicornia bigelovii Torr., also known as Salicornia bigelovii Torr., belongs to the genus Salicornia L. of Chenopodiaceae, and can be directly irrigated with seawater. The cultivation of Salicornia is beneficial to improving the ecological environment, constructing ecological wetlands, and providing food and habitat for wild birds. [0003] At the same time, Salicornia has a variety of comprehensive utilization methods. The oil content of its seeds is about 30%, and the unsaturated fatty acid content is as high as 90%. 40 times that of vegetables, and can be used as raw materials for green organic vegetabl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61K31/7028A61P35/00A61P29/00
Inventor 管福琴冯煦赵友谊王奇志单宇印敏王鸣陈雨孙浩
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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