Compound oil-in-water cnidium fruit oil nanoemulsion composition and preparation method thereof

Abstract

The invention discloses a compound oil-in-water cnidium fruit oil nanoemulsion composition. The particle size of the nanoemulsion composition is between 1 nm and 100nm. The nanoemulsion composition comprises the following raw materials in percentage by mass: 0.1 to 9.0 percent of cnidium fruit oil, 0.1 to 3.5 percent of eugenol, 0.1 to 2.0 percent of amitraz, 20.0 to 35.0 percent of surfactant, 0.1 to 6.0 percent of cosurfactant and the balance of distilled water, wherein the total percentage by weight of the raw materials is 100 percent. The compound cnidium fruit oil nanoemulsion has the effects of killing pests, relieving itching and killing bacteria and can be applied to the treatment of parasites (such as sarcoptic mites, psoroptidae, ticks, lice and the like) on body surfaces of animals. Through the compound oil-in-water cnidium fruit oil nanoemulsion composition, the stability and the bioavailability of the medicament are improved, the dosage of the medicament is reduced, the permeability is high, the insecticidal range is wide, the effect is obvious, and the preparation method is simple. Therefore, the compound oil-in-water cnidium fruit oil nanoemulsion composition is convenient to popularize and has wide market prospect in the field of medicaments.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound oil-in-water type cnidium oil nanoemulsion composition and a preparation method thereof, which can be used for treating animal epiparasites (such as scabies mites, itch mites, ticks, lice, etc.). Background technique [0002] Mites, ticks, lice, etc. are common surface parasites in veterinary clinics. They often cause flushing, rash-like nodules on the skin surface of animals, local hair loss, inflammation, secretions and scabs. Animals are extremely itchy and restless , Scratching, biting, rubbing the affected skin. Although simple ectoparasitic diseases do not cause the death of animals, they seriously affect the quality of life and production performance of animals, especially when infected with pathogenic bacteria, fungi, viruses and other pathogens, it may be life-threatening. Some parasites are zoonotic and pose a threat to human health. Therefore, this disease cannot be ...

AI Technical Summary

Problems solved by technology

[0005] At present, people's utilization of Cnidium oil is mainly limited to the original drug. Although the original drug has a certain curative effect, its external skin penetration rate is low, the drug bioavailability is not high, its drug properties have not reached full play, the insecticidal range is limited, and the disease is easy to treat. relapse

Other formulations on the market are also seldom, which directly affects the popularization and use of Cnidium oil

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