Bioprotein sponge and preparation method thereof

Abstract

The invention discloses bioprotein sponge and a preparation method thereof. According to the characteristics that internal cells of a human body and an animal body adapt to cell growth environments, the bioprotein is freezed into a dry sponge shape through freeze drying technology by utilizing intercellular substances as controlled-release carrieres of growth factors and acts on the trauma of the human body or the animal body in controlled-release medicament feeding mode. The preparation method of the bioprotein sponge changes the traditional preparation process, adopts S / D virus inactivation, and adds protective agent to reduce probability of virus cross infection of people and livestock simultaneously. The CM cation chromatographic purification process improves purity of bioprotein, promotes stanching and tissue union effect of the bioprotein sponge and reduces clinical side effect. An ultrafiltration process is adopted to replace a dialysis process, so that preparation period is shortened, activity of the bioprotein is protected, and production cost is reduced. A method of heating inactivation virus replaces the method of cobalt60 radiation sterilization, so that the fact that radiation rays bring damage to products is avoided, the activity of the bioprotein is protected, and safe and reliable use of products in clinical application is achieved.

Description

technical field [0001] The present invention relates to a kind of biological protein sponge for medical clinical operation and human body trauma and its manufacturing method; especially relates to a kind of hemostasis that is used for the fresh wound of human body and animal body, promotes the ability of cell growth and proliferation, and the biological protein sponge of blood vessel and organ tissue repair. Protein sponge and preparation method thereof. Background technique [0002] In the medical field, wound repair and postoperative body growth and regeneration are a related pathophysiological process. It is well known that after clinical surgery and other trauma repairs, it includes a series of biochemical, physiological and morphological changes in the human body. Usually, from the beginning of blood coagulation to inflammatory response, cell infiltration, neovascularization, and extracellular matrix production, each stage is an orderly process of interdependence. These...

AI Technical Summary

Problems solved by technology

[0006] It can be clearly seen from the prior art disclosed above that the products produced by the preparation method can only use one of the characteristics of a single performance. Although it also reflects some characteristics of the growth factor, it is necessary for the maximum application growth There are no substantial breakthroughs and applications in terms of the biological activity of factors, slow release of growth factors, activation of repair ability of tissue cells, and safety during clinical application; therefore, in the process of clinical application, there are single, Issues such as limited comprehensive applications