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A kind of hydrogel antibacterial gauze dressing and preparation method thereof

A technology of hydrogel and hydrogel layer is applied in the field of hydrogel antibacterial gauze dressing and its preparation, which can solve the problems of weak toxicity and side effects of nano silver, achieve rapid healing, resist bacterial invasion, and good thermal stability. Effect

Active Publication Date: 2018-06-08
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic research on the toxic and side effects of nano-silver is relatively weak, and the US FDA has explicitly banned the use of nano-silver

Method used

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  • A kind of hydrogel antibacterial gauze dressing and preparation method thereof
  • A kind of hydrogel antibacterial gauze dressing and preparation method thereof
  • A kind of hydrogel antibacterial gauze dressing and preparation method thereof

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preparation example Construction

[0037] The preparation method of hydrogel antibacterial gauze dressing of the present invention can be carried out according to the following steps:

[0038] The first step: disperse the above-mentioned hydrophilic polymer and glycerin in the purified water in sequence, mix and stir evenly, after fully swelling, add the above-mentioned inorganic nano-antibacterial agent by weight, mix and stir again to form a uniform mixture, that is is a hydrogel;

[0039] The second step: uniformly coat the hydrogel obtained in the first step on the support layer to form a hydrogel layer, and then cover the exposed parts of the hydrogel layer and the support layer with a protective layer, to obtain finished product.

[0040] In order to clearly illustrate the purpose of the present invention, the present invention will be described in more detail below through two sets of comparative experiments.

[0041] 1) Change the types of inorganic nano-antibacterial agents

[0042] In the present i...

Embodiment 1

[0081] Weigh 20g of hydroxyethylcellulose and 30g of sodium carboxymethylcellulose and disperse them in 890g of purified water. After fully swelling, add 10g of glycerin, mix well, then add 50g of nano-zinc oxide powder, and stir well to form a uniform mixture. A hydrogel is obtained.

[0082] The hydrogel obtained above is evenly coated on the polyester fiber gauze of the supporting layer, and then the exposed part of the hydrogel layer and the supporting layer is covered with a PE film as a protective layer to obtain the finished product of the present invention.

[0083] The coating weight of hydrogel layer is 500g / m in the present embodiment 2 .

[0084] In order to facilitate portability, a release paper can be arranged on the outside of the protective layer.

[0085] Among them, the molecular weight of hydroxyethyl cellulose is 100,000-30,000, the molecular weight of sodium carboxymethyl cellulose is 15,000-30,000, and the degree of deacetylation is 85%; The average p...

Embodiment 2

[0087] Weigh 10g of sodium carboxymethylcellulose and disperse it in 905g of purified water. After fully swelling, add 35g of glycerin, mix well, then add 50g of nanometer zinc oxide powder, stir well and form a uniform mixture to obtain a hydrogel.

[0088] The hydrogel obtained above is evenly coated on the polyester fiber gauze of the supporting layer, and then the exposed part of the hydrogel layer and the supporting layer is covered with a PU film as a protective layer to obtain the finished product of the present invention.

[0089] The coating weight of hydrogel layer is 550g / m in the present embodiment 2 .

[0090] In order to facilitate portability, a release paper can be arranged on the outside of the protective layer.

[0091] Among them, the molecular weight of sodium carboxymethylcellulose is 50,000-100,000, and the degree of deacetylation is 75%; the average particle size of zinc oxide powder, an inorganic nano-antibacterial agent, is 10-100nm.

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Abstract

The invention belongs to the technical field of medical materials and their preparation. The invention provides a hydrogel antibacterial gauze dressing and a preparation method thereof. The hydrophilic polymer and glycerin are respectively dispersed in purified water, mixed and stirred evenly, after sufficient swelling, an inorganic nano antibacterial agent is added, and the mixture is mixed and stirred again to form a uniform The homogeneous mixture is the hydrogel; then the obtained hydrogel is uniformly coated on the support layer to form a hydrogel layer, and then the exposed part of the hydrogel layer and the support layer is covered with a protective layer, that is get finished product. The hydrogel antibacterial gauze dressing obtained by the invention has good biocompatibility, rapidly promotes wound healing, good stability, no toxic and side effects, and obvious antibacterial effect.

Description

technical field [0001] The invention belongs to the technical field of medical materials and their preparation, and in particular relates to a hydrogel antibacterial gauze dressing and a preparation method thereof. Background technique [0002] The human skin will be traumatized by various external factors, thus losing its natural protective function, and then the tissue will be infected by the invasion and reproduction of microorganisms such as Escherichia coli and Staphylococcus aureus, and cause other complications. The use of medical dressings can largely prevent microorganisms and dust from entering wound tissue, facilitate wound care, and promote rapid wound healing. [0003] Traditional gauze dressings are mainly made of cotton and linen materials through deep processing. They have the advantages of simple manufacturing process, low price, and convenient use. Currently, this type of dressing is widely used in the market. However, traditional gauze dressings cannot ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/46A61L15/42A61L15/44A61L15/26A61F13/02
Inventor 朱天钢刘尧张艳琦
Owner HENAN HUIBO MEDICAL CO LTD
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