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Preparation method of high-strength hydrogel

A hydrogel, high-strength technology, applied in the field of hydrogels, can solve the problems of complex and time-consuming preparation process, restricting the application of high-strength hydrogels, etc., and achieves green and safe preparation process, short preparation process time, and energy consumption. small effect

Inactive Publication Date: 2014-04-23
HENAN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although some important achievements have been made in the design and preparation of high-strength hydrogels, the preparation process of high-strength hydrogels is generally complicated and time-consuming or requires cumbersome steps to synthesize functional monomers, which limits high-strength hydrogels. Application of glue in various fields

Method used

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  • Preparation method of high-strength hydrogel
  • Preparation method of high-strength hydrogel
  • Preparation method of high-strength hydrogel

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preparation example Construction

[0027] A method for preparing a high-strength hydrogel. The specific preparation method is that the high-strength hydrogel adopts a "one-pot cooking" method, that is, the first step required for the preparation of the hydrogel to form a double-network gel. The polymer of the network, the monomer used to polymerize the second network of the double-network hydrogel, the initiator used to initiate the polymerization of the monomer, and the cross-linking reaction to occur simultaneously during the polymerization of the monomer to form the second network hydrogel The heavy network cross-linking agent and water are mixed directly at one time, and all substances are dissolved to form a homogeneous solution through certain stimulating conditions, and then the polymerization is initiated by heat or light to obtain a high-strength hydrogel;

[0028] The polymer used to form the first network of the double network gel is agar, agarose, gelatin, collagen, fibrin, alginate, hyaluronate, cho...

Embodiment 1

[0038] 20 mg agar, 2400 mg acrylamide, 0.0575 g 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 78 μL N,N'-methylenebisacrylamide solution ( 20 mg / mL) was accurately weighed into the reactor, and then 10 mL of deionized water was added. After sealing the reaction liquid, circulate deoxygenation and nitrogen flushing three times, at 90~95 o Heat and stir in an oil bath or water bath in C for 5-10 min to form a homogeneous transparent clear solution, then pour the solution into a reaction mold and allow it to cool to room temperature to form an agar gel. The above agar gel can be obtained after the polymerization reaction is initiated under 365 nm ultraviolet light for 1 h. figure 1 , 2 , 3, and 4 for high-strength hydrogels (gels can be bent, knotted, compressed, and stretched without breaking). The stress-strain curve of agar / polyacrylamide high strength hydrogel (Agar / PAM DN gel) tensile test is as Figure 5 As shown, among the figure a is the stress-strain curve of...

Embodiment 2

[0040] Accurately weigh 50 mg gelatin, 2000 mg acrylamide, and 29 μL N,N'-methylenebisacrylamide solution (20 mg / mL) into the reactor, and then add 10 mL deionized water. After the reaction solution is sealed, the cycle deoxygenation and nitrogen flushing three times, at 60 o Heat and stir in an oil bath or water bath in C for 5-10 min to form a homogeneous transparent clear solution, add 120 μL of ammonium persulfate or potassium persulfate aqueous solution (20 mg / mL) and pour the solution into the reaction mold to make at 60 o C reacted for 2 h and then in 4 o C to cool for 0.5 h. The tensile strength is 1.2 MPa, the tensile modulus is 146 KPa, the elongation at break is 1740%, the compressive strength is about 40 MPa, the compressive modulus is about 155 KPa, the compressive strain is 96%, and the toughness of the gel reaches 800 J / m 2 .

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Abstract

The invention relates to a high-strength hydrogel and a preparation method thereof. The preparation method comprises the steps of directly mixing a polymer, a monomer, an initiator, a cross-linking agent and water once, dissolving all the substances to form a homogeneous solution under a certain simulation condition, and then initiating and polymerizing by using heat or light to obtain the high-strength hydrogel, wherein the polymer is needed for preparation of the hydrogel and used for forming a first double network of a dual-network hydrogel; the monomer is used for polymerizing and forming a second double network of the dual-network hydrogel; the initiator is used for initiating the monomer to be polymerized; the cross-linking agent is used for performing cross-linking reaction in a monomer polymerizing process so as to form the second double network. According to the preparation method, a one-pot method is used for preparing the high-strength hydrogel, so that the method is simple and practicable; the prepared high-strength hydrogel has the characteristics of high strength and high toughness; a tensile strength of the gel is 0.6-1.2MPa, a tensile modulus is 100-200 KPa and a tensile strain reaches 1000-2680%; the prepared high-strength hydrogel can be widely applied to the fields of tissue repair, artificial organ, drug sustained release, sensors and the like.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a preparation method of a high-strength hydrogel. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure formed by chemical cross-linking or physical cross-linking. The polymer network contains a large amount of water and is soft to the touch and can maintain a certain shape. This characteristic has many similarities with biological soft tissues. . Hydrogel usually has both solid and liquid properties, and has the characteristics of changing its shape or state in response to the external environment, so that it can absorb, desorb, transport, and permeate substances, that is, it has the ability to hold, separate, and slow-release substances. function. These unique structures and functions of hydrogels have broad development and application prospects in life sciences, food sciences, selective adsorption, drug controlled release, biosensors, and tissu...

Claims

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Application Information

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IPC IPC(8): C08J3/28C08J3/075C08F220/56C08F220/06
Inventor 陈强朱琳黄丽娜李云飞张记升
Owner HENAN POLYTECHNIC UNIV
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