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Preparation method of gynecological inflammation clearing vaginal effervescent tablet

An effervescent tablet and vaginal technology is applied in the field of preparation of Fuyanping vaginal effervescent tablets, which can solve the problems of product instability, insufficient hardness, sticking and punching, etc., so as to solve the problem of gas production, improve product hardness, and improve product quality and productivity effects

Active Publication Date: 2013-04-03
JIANGXI JIMINKEXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are Fuyanping San, Fuyanping Capsules, Fuyanping Vaginal Effervescent Tablets and other dosage forms, among which Fuyanping Vaginal Effervescent Tablets have a fast onset of action, directly reach the focus of the disease, and achieve the purpose of treatment. Because of Fuyanping vaginal effervescent There are many problems in the production of tablets, such as sticking, slitting, insufficient hardness, and gas production during storage, which makes the product unstable

Method used

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  • Preparation method of gynecological inflammation clearing vaginal effervescent tablet
  • Preparation method of gynecological inflammation clearing vaginal effervescent tablet
  • Preparation method of gynecological inflammation clearing vaginal effervescent tablet

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Experimental program
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Effect test

Embodiment 1

[0061] The prescription of Fuyanping vaginal effervescent tablets is as follows:

[0062] Sophora flavescens 500g Bitterwood 400g Cnidium 400g Dry alum 100g Pearl layer powder 5g

[0063] Borneol 10g Menthol 4g Berberine hydrochloride 40g Boric acid 60g

[0064] The above nine flavors, 200g of Sophora flavescens, bitter wood and Fructus Cnidii are crushed into medium powder, according to the percolation method under the item of extract and liquid extract (Appendix IO of Chinese Pharmacopoeia 2010 Edition), use 80% ethanol as solvent, impregnate After 48 hours, carry out percolation at a speed of 3ml / kg·min, collect the percolation liquid, recover ethanol and concentrate it into a thick paste, add berberine hydrochloride, nacre powder and sodium carboxymethyl starch, mix well, and heat at 80°C Dried and set aside; to obtain dry cream powder.

[0065] Craft 1

[0066]

[0067]

[0068] (1) Preparation of sodium bicarbonate coating agent: Weigh 48g of PEG6000 and 96g of ...

Embodiment 2

[0092] Sophora flavescens 500g Bitterwood 400g Cnidium 400g Dry alum 100g Pearl layer powder 5g

[0093] Borneol 10g Menthol 4g Berberine hydrochloride 40g Boric acid 60g,

[0094] The selected auxiliary materials are: sodium carboxymethyl starch, citric acid, sodium bicarbonate, polysorbate 80, povidone K30, ethanol, menthol, magnesium stearate.

[0095] The preparation method is as follows:

[0096] The above nine flavors, 200g of Sophora flavescens, bitter wood and Fructus Cnidii are crushed into medium powder, according to the percolation method under the item of extract and liquid extract (Appendix IO of Chinese Pharmacopoeia 2010 Edition), use 80% ethanol as solvent, impregnate After 48 hours, carry out percolation at a speed of 3ml / kg min, collect 6600ml of percolation liquid, reclaim ethanol and concentrate into a thick paste, add berberine hydrochloride, nacre powder and sodium carboxymethyl starch, mix well, and Dry at 80°C and set aside to obtain dry cream powder....

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Abstract

The invention belongs to the field of pharmacy, and particularly relates to a gynecological inflammation clearing vaginal effervescent tablet. The tablet is prepared from the following Chinese medicinal bulk pharmaceutical chemicals: 500g of sophora flavescens, 400g of quassia, 400g of common cnidium fruit, 100g of dried alum, 5g of pearl stratum powder, 10g of borneol, 4g of menthol, 40g of berberine hydrochloride and 60g of boric acid. The gynecological inflammation clearing vaginal effervescent tablet contains auxiliary components which comprise acid, alkali, a filler, a disintegrating agent, a lubricant and a coating agent.

Description

technical field [0001] The invention relates to a preparation method of Fuyanping vaginal effervescent tablets, belonging to the technical field of medicine. technical background [0002] Vaginitis is a common gynecological disease in gynecology. Fuyanping preparation composed of Sophora flavescens, bitter wood, cnidium, alum, nacre powder, borneol, menthol, berberine hydrochloride, boric acid and other ingredients has the effect of clearing away heat and detoxifying , dry dampness to stop belt, kill insects and relieve itching. For liver meridians with damp heat, profuse leukorrhagia, yellowish pus, or foamy rice swill, foul smell, genital flushing, swelling, itching, vexation, less sleepiness, bitter mouth and chest tightness; vaginitis caused by trichomonas, fungi, and bacteria , Vulvitis see the above symptoms. [0003] At present, there are Fuyanping San, Fuyanping Capsules, Fuyanping Vaginal Effervescent Tablets and other dosage forms, among which Fuyanping Vaginal E...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K36/534A61K31/045A61K31/4375A61K33/06A61K33/22A61K35/56A61K47/36A61K47/38A61P15/02A61K35/618
Inventor 文万江
Owner JIANGXI JIMINKEXIN PHARMA
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