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Compound Omeprazole tablets and preparation method thereof

A technology of omeprazole tablets and omeprazole, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, pill delivery, etc., can solve the problem of high energy consumption and unsuitable Large-scale industrial production, large amount of antacids, etc.

Inactive Publication Date: 2012-02-01
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the dosage of antacid in the preparation is very large, and the energy consumption of micro-differentiated sodium bicarbonate and magnesium hydroxide is large, and the loss is serious, so it is not suitable for large-scale industrial production

Method used

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  • Compound Omeprazole tablets and preparation method thereof
  • Compound Omeprazole tablets and preparation method thereof
  • Compound Omeprazole tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Prescription:

[0023] Omeprazole

2kg

sodium bicarbonate

75kg

magnesium hydroxide

34.3kg

Titanium dioxide

1kg

5% sodium carboxymethylcellulose solution

50L

Crospovidone

2kg

Sodium stearyl fumarate

0.5g

A total of 100,000 pieces were made

[0024] 2. Process steps:

[0025] Omeprazole and titanium dioxide powder are dispersed in 5% sodium carboxymethylcellulose aqueous solution, after stirring evenly, carry out spray drying with spray drier, obtain dry omeprazole polymer material fusion, standby (spray condition: Inlet air temperature: 125°C; outlet air temperature: 76°C; feeding rate: 0.5L / min). Mix omeprazole polymer material fusion, sodium bicarbonate, magnesium hydroxide, croscarmellose sodium and sodium stearyl fumarate through a 100-mesh sieve, mix evenly and directly compress into tablets with a hardness of 10 -16kg.

[0026] Influencing factors and stability...

Embodiment 2

[0041] 1. Prescription:

[0042] Omeprazole

2kg

sodium bicarbonate

100kg

magnesium hydroxide

20kg

Titanium dioxide

1kg

8% hypromellose solution

50L

Croscarmellose Sodium Starch

2kg

Sodium stearyl fumarate

0.5g

A total of 100,000 pieces were made

[0043] 2. Process steps:

[0044] Omeprazole and titanium dioxide powder are dispersed in 5% hypromellose aqueous solution, after stirring evenly, carry out spray drying with spray drier, promptly obtain dry omeprazole polymer material fusion, standby (spray condition: advance Air temperature: 125°C; outlet air temperature: 76°C; feeding rate: 0.5L / min). Mix omeprazole polymer material fusion, sodium bicarbonate, magnesium hydroxide, croscarmellose sodium starch sodium and sodium stearyl fumarate through a 100-mesh sieve, mix evenly and directly compress into tablets with a hardness of 10- 16kg.

[0045] Investigation of influencin...

Embodiment 3

[0055] 1. Prescription:

[0056] Omeprazole 4kg

[0057] Sodium bicarbonate 500kg

[0058] Magnesium hydroxide 650kg

[0059] Titanium dioxide 3kg

[0060] 8% hydroxypropyl cellulose solution 25L

[0061] Croscarmellose Sodium 4kg

[0062] Sodium stearyl fumarate 1kg

[0063]

[0064] A total of 100,000 pieces were made

[0065] 2. Process steps:

[0066] Omeprazole and titanium dioxide powder are dispersed in 8% hydroxypropyl cellulose aqueous solution, carry out spray drying with spray drier after stirring, obtain dry omeprazole polymer material fusion (spray condition: inlet air temperature: 125°C; air outlet temperature: 76°C; feeding rate: 0.5L / min), for standby. Mix omeprazole polymer material fusion, sodium bicarbonate, magnesium hydroxide, croscarmellose sodium starch sodium and sodium stearyl fumarate through a 100-mesh sieve, mix evenly and directly compress into tablets with a ...

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Abstract

The invention discloses compound Omeprazole tablets, comprising the following ingredients: 20-40 weight portions of Omeprazole, 500-1000 weight portions of sodium bicarbonate, 200-652 weight portions of magnesium hydroxide, 10-30 weight portions of opacifier, 20-40 weight portions of water-soluble polymer material, 20-40 weight portions of disintegrating agent, and 5-10 weight portions of lubricant. The dissolution time of Omeprazole in the compound Omeprazole tablets is slightly lagged, so that antacid is dissolved in advance to neutralize the gastric acid, and the purposes of reducing drug degradation, gastricsolubility and quick release are achieved; and simultaneously, the light stability is increased, and the production operation and storage is convenient.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound omeprazole tablet and a preparation method thereof. Background technique [0002] Digestive system disease is one of common frequently-occurring diseases, wherein is based on ulcer disease, and total sickness rate accounts for about 10~20% of population. About 10% of patients with peptic ulcer disease in the United States, 12.3% in Germany; According to a survey in a few areas in my country, the incidence of digestive tract diseases is 11.43%, of which the incidence of peptic ulcer is 4.54%. [0003] With the social development of our country, environmental changes, changes in population structure and people's lifestyles, mainly due to smoking, drinking, emotional stress, drug stimulation, etc., the incidence of peptic ulcer has gradually increased, becoming a common and frequently-occurring disease. It causes great suffering to the patients and le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4439A61K47/38A61K47/04A61P1/04
Inventor 王国华梅勇刘萍杨勇罗磊杨莉
Owner 重庆健能医药开发有限公司
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