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Composition of malaytea scurfpea extract as well as preparation method and use thereof

A technology of psoralen extract and composition, which is applied in the preparation of traditional Chinese medicine psoralen extract extract powder, and in the field of powder preparation of traditional Chinese medicine extract extract, which can solve the problem of difficulty in forming powder and reducing drug consumption. Containment rate, granule/powder softening, etc.

Inactive Publication Date: 2011-11-02
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extracts of such traditional Chinese medicines often form viscous extracts after concentration, which leads to many problems in the preparation process of preparations: stickiness, difficulty in drying, and difficulty in forming powders suitable for preparations; Difficult to disperse evenly, granules are easy to soften when heated, etc. It is often necessary to add a large amount of excipients to fully absorb the thick paste extract, form a powder, and then prepare a solid preparation
[0004] Various types of psoralen extracts, such as the alcohol extract of psoralen, are usually some extracts with high viscosity, which have many problems of difficult processing when preparing solid preparations, For example, more excipients need to be added for formulation molding, which reduces the drug’s capacity in the formulation, poor fluidity of granules / powders affects accurate dosing, granules / powders generate heat during processing and become soft, etc.

Method used

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  • Composition of malaytea scurfpea extract as well as preparation method and use thereof
  • Composition of malaytea scurfpea extract as well as preparation method and use thereof
  • Composition of malaytea scurfpea extract as well as preparation method and use thereof

Examples

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Effect test

example 1

[0065] Extract Example 1: Preparation of Psoralen Extract

[0066] 1 kg of psoraleae medicinal material (purchased from Henan Xinyang Pharmaceutical Co., Ltd.) was percolated and extracted with 10 times the amount of 70% ethanol for 4 hours, and the ethanol was recovered under reduced pressure to obtain a dark brown viscous oily extract with a relative density of 1.16 (60° C. ), yield 12.4%, serial number: BGZ-1.

[0067] Detected by HPLC, the extract contains psoralen 1.42% (w / w), isopsoralen 1.18% (w / w) and bakuchiol 32.89% (w / w). The chromatogram is shown in the attached figure 2 .

[0068] Extract Example 2: Preparation of Psoralen Extract

[0069] 1 kg of psoraleae medicinal material (purchased from Henan Xinyang Pharmaceutical Co., Ltd.) was crushed into a coarse powder (without sieve), refluxed with 10 times the amount of 95% ethanol as a solvent for extraction for 4 hours, and placed on a macroporous adsorption resin (D101). Elute and purify with 95% ethanol, c...

preparation example 1

[0114] Preparation Example 1: Granules of Psoraleae Extract (calculated in 1000g)

[0115]

[0116]

[0117] [Preparation] After fully mixing the drug and auxiliary materials, use 3% PVP in 80% ethanol solution to make soft materials, pass through a 14-mesh nylon sieve to granulate, dry the wet granules at 40°C, pass the dry granules through a 14-mesh sieve for granulation, and then Sieve through a No. 4 sieve (65 mesh) to remove fine powder, pack separately, and obtain.

preparation example 2

[0118] Preparation Example 2: Capsules of Psoralen Extract (1000 capsules)

[0119]

[0120] [Preparation] After fully mixing the drug and auxiliary materials, use 85% ethanol solution to make a soft material, pass through a 14-mesh nylon sieve to granulate, dry at 70°C until the water content is below 3%, and put it into a No. 3 capsule shell.

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Abstract

The invention discloses a composition of malaytea scurfpea extract as well as the preparation method and use thereof. The composition contains a malaytea scurfpea extract, cyclodextrin and an optional excipient acceptable in the physiology. The extract of the invention has an excellent processing performance.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine products, and relates to a preparation method and application of Chinese medicine extract extract powder, in particular to a preparation method and application of traditional Chinese medicine psoraleae extract powder preparation method. Background technique [0002] Psoralea (Psoralea. corylifolia L.) is an annual erect herb of the genus Psoralea in the family Fabaceae, widely distributed in my country. According to the records of "Flora of China", psoraleae is used as medicine with its seeds, which has the functions of invigorating the kidney and strengthening yang, invigorating the spleen and stomach, and can treat skin diseases such as psoriasis. Vietnam uses its alcohol extract to treat rheumatism. Modern studies have shown that psoraleae has physiological activities such as anti-oxidation, antibacterial, anti-tumor, boosting blood pressure, inducing melanocyte migration, and estrog...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61K47/48A61P5/30A61P9/02A61P31/04A61P35/00A61P39/06
Inventor 王亚静高秀梅刘二伟王跃飞胡利民田慧
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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