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Embolic agent and preparation method thereof

An embolic agent and embolization technology, applied in the field of materials, can solve problems such as high embolism density, mass effect, and patient discomfort, and achieve the effects of promoting cell differentiation, preventing blood recanalization, and accelerating vascular endothelialization

Active Publication Date: 2014-05-21
MICROPORT NEUROTECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liquid embolic material disclosed in the prior art is solidified in the blood to form an embolic body with a relatively high density, causing a huge space-occupying effect when the aneurysm is completely embolized, causing great discomfort to the patient

Method used

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preparation example Construction

[0027] The present invention also provides a preparation method of embolic agent, comprising:

[0028] Physically doping or chemically bonding the degradable polymer and the liquid embolic material to obtain a first solution;

[0029] A contrast agent is added to the first solution to obtain an embolic agent.

[0030] According to the present invention, the temperature at which the degradable polymer is physically doped or chemically bonded with the liquid embolic material is preferably 40-80°C, more preferably 50-70°C. The physical doping or chemical bonding of the degradable polymer and the liquid embolic material is preferably carried out under the protection of argon, preferably by stirring to achieve the purpose of thorough mixing, and the stirring time is preferably 1-12 hours, more preferably 2-10 hours. The adding of the contrast agent to the first solution is preferably carried out under the protection of argon, preferably by stirring, and there is no special limitat...

Embodiment 1

[0034] Add 10 g of ethylene vinyl alcohol polymer (EVOL) with a number average molecular weight of 60,000 to 100 ml of dimethyl sulfoxide (DMSO), and stir for 2 hours at a temperature of 50°C in an argon atmosphere; add 3 g of Polylactic acid with an average molecular weight of 150,000 was stirred at a temperature of 70°C in an argon atmosphere for 5 hours to obtain a uniform solution; 30g of tantalum powder was added to the above uniform solution, and stirred until it was evenly dispersed; put it into a container, seal it, and extinguish it. Store after sterilization.

Embodiment 2

[0036] Add 10 g of cellulose acetate polymer (CAP) with a number average molecular weight of 60,000 to 100 ml of DMSO, and stir for 2 hours at a temperature of 50° C. in an argon atmosphere; add 3 g of polyethylene glycol with a number average molecular weight of 150,000 to the above solution. For lactide, stir for 5 hours at a temperature of 70°C in an argon atmosphere to obtain a uniform solution; add 30g of tantalum powder to the above uniform solution, stir until uniformly dispersed; put it in a container, seal it, and store it after sterilization.

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PUM

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Abstract

An embolic agent and a preparation method therefore are disclosed. The embolic agent comprises a liquid embolic material, a degradable polymer, and a contrast agent. The preparation method comprises physically blending a degradable polymer and a liquid embolic material, or chemically bonding the degradable polymer to the liquid embolic material, to obtain a first solution; adding a contrast agent to the first solution, to obtain the embolic agent. Due to the gradual degradation of the degradable polymer, an embolic body forms a system with a porous structure, thereby lowering the density of the embolic agent and effectively relieving the mass effect.

Description

technical field [0001] The present invention relates to the technical field of materials, and more specifically relates to an embolic agent and a preparation method thereof. Background technique [0002] Due to internal and external factors such as mechanical injury, vascular sclerosis, high blood pressure, proliferation of vascular smooth muscle cells, bacterial or viral infection, induction of venous valve disease, or blood flow impact, hemangiomas will form in arteriovenous vessels. Hemangiomas are classified into aneurysms and venous aneurysms, and among them, aneurysms with rounded convex walls that occur in the brain are called cerebral aneurysms. Cerebral aneurysms can easily induce subarachnoid hemorrhage when they rupture, leading to stroke in patients; even, 80% or more patients will die after recurrent cerebral aneurysm rupture. Therefore, embolization or closure of cerebral aneurysm as early as possible is the best cure. [0003] In the method of embolization o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/18
CPCA61L24/0042A61L2430/36A61L31/148A61K47/12A61L31/18A61L24/001A61K9/0019
Inventor 李雨康亚红金巧蓉谢志永罗七一
Owner MICROPORT NEUROTECH SHANGHAI
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