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Qingpeng spray preparation for relieving pain and swelling and preparation method thereof

A preparation and propellant technology, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., to achieve the effects of advanced dosage forms, improved dissolution rate, and improved therapeutic effect

Active Publication Date: 2012-12-19
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no reports on the preparation of sprays or aerosols and products based on the prescription of the traditional Tibetan medicine Qingpeng ointment by modifying the dosage form.

Method used

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  • Qingpeng spray preparation for relieving pain and swelling and preparation method thereof
  • Qingpeng spray preparation for relieving pain and swelling and preparation method thereof
  • Qingpeng spray preparation for relieving pain and swelling and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0095] The preparation method of Qingpeng spray or aerosol of the present invention comprises a kind of in following A, B method:

[0096] A method:

[0097] ① Grind musk into fine powder;

[0098] ②Respectively remove impurities, wash Oxytropis chinensis, sub-rhubarb, iron rod hammer, seed myrobalan, myrobalan, emblica, benzoin, and vine, and pulverize them into medicinal powders with a particle size of 0.1-150 μm;

[0099] ③ Dissolve solubilizer, humectant, excipient and emulsifier with 40-90% ethanol, then add the medicated powder obtained in step ②, musk fine powder and preservative obtained in step ①, stir well, add ethanol to make the Alcohol content reaches 40-85%, mix well, fill, seal or fill in propellant, obtain the Qingpeng spray or aerosol of the present invention.

[0100] Method B:

[0101] ① Remove impurities, wash and mix Oxytropis, subrhubarb, iron rod hammer, seed myrobalan, myrobalan, emblical, benzoin, and vine respectively;

[0102] ② Weigh 10%-100% of...

experiment example 1

[0194] Experimental example 1: Experimental example 1: Screening experiment of various excipients

[0195] 1. Optimization experiment of excipients

[0196] ① Selection of excipients

[0197]Weigh 100 parts by weight of Oxytropis, 50 parts by weight of subrhubarb, 75 parts by weight of iron bar hammer, 100 parts by weight of myrobalan, 100 parts by weight of myrobalan, 100 parts by weight of emblica, 35 parts by weight of benzoin, vine vine 150 parts by weight, 25 parts by weight of musk, ground musk into fine powder; reflux extraction with 60% ethanol with 10, 8, and 6 times the total weight of the drug, respectively, for 90, 60, and 30 minutes each time, and collecting and merging The extract is filtered and concentrated into a concentrated solution with a relative density of 1.05-1.15; 150 g of Tween 80, 300 parts by weight of glycerin and 250 g of different types of excipients are dissolved in 90% ethanol, then the concentrated solution and musk powder are added, and the ...

experiment example 2

[0242] Experimental example 2: Qingpeng spray and aerosol of the present invention and Qingpeng ointment transdermal absorption test comparison

[0243] 1. Test sample:

[0244] Traditional Qingpeng ointment: provided by Tibet Qizheng Tibetan Medicine Co., Ltd.;

[0245] Qingpeng ointment 1: Preparation method: ①Pure Oxytropis 100g, subrhubarb 50g, iron rod hammer 75g, chebula 100g, chebula 100g, emblica 100g, benzoin 35g, and vine vine 150g, crush and mix Uniform and ready for use; ②Weigh 50% of the total weight of the above-mentioned mixed raw materials, use 2.13kg of water, decoct 3 times at 85°C, decoct for 2 hours each time, collect the extract and volatile oil respectively; filter, concentrate and extract Add the volatile oil to the concentrated solution; ③ Grind the above-mentioned remaining mixed raw material medicine into a 100 μm powder, and mix it with the above-mentioned concentrated solution containing volatile oil to obtain a mixed solution a; Add liquid a to 5...

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Abstract

The invention provides a spray preparation for relieving pain and swelling, which comprises active ingredients and a substrate, wherein the active ingredients are prepared from the following raw material medicaments in part by weight: 80 to 120 parts of oxytropis, 30 to 70 parts of sub-rhubarb, 50 to 100 parts of tiebangchui aconite tuber, 80 to 120 parts of core removal medicine terminalia fruit, 80 to 120 parts of terminalia bellerica, 80 to 120 parts of emblic leafflower fruit, 20 to 50 parts of benzoin, 130 to 170 parts of Chinese tinospora stem and 10 to 40 parts of musk; and the substrate comprises the following auxiliary materials in part by weight: 100 to 800 parts of excipient and 50 to 500 parts of emulsifier. The spray preparation has the characteristics of advanced formulations, simplicity and convenience for process, quick response and the like. On the basis of ensuring a curative effect, the quality of products is improved, beneficiaries are enlarged, and the quality of the products is safer, more stable and controllable.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical preparation for relieving pain and reducing swelling and a preparation method thereof. Background technique [0002] Qingpeng Ointment is a classic Tibetan medicine prescription composed by Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. The prescription is included in the 95th edition of "Drug Standards issued by the Ministry of Health" The first volume of medicine, 322 pages. [0003] The prescription of Qingpeng ointment is: Oxytropis falciparum 100g, subrhubarb 50g, iron rod hammer 75g, myrobalan 100g, myrobalan 100g, emblical 100g, benzoin 35g, vine vine 150g, musk 25g. [0004] The preparation method is as follows: the above nine flavors, except musk, which are ground into fine powder, the rest are ground into fine powder, sieved, added musk fine powder, mixed evenl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K36/714A61P29/00A61P19/06A61P17/00A61K35/55
Inventor 李晓强张樱山陈丽娟张国霞卢伍党
Owner TIBET QIZHENG TIBETAN MEDICINE
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