Cross-linked polyquaternary ammonium salt type antibiosis monomer, preparation method of cross-linked polyquaternary ammonium salt type antibiosis monomer and application of cross-linked polyquaternary ammonium salt type antibiosis monomer in dentistry repairing materials

Abstract

The invention discloses a cross-linked polyquaternary ammonium salt type antibiosis monomer, a preparation method of the cross-linked polyquaternary ammonium salt type antibiosis monomer and application of the cross-linked polyquaternary ammonium salt type antibiosis monomer in dentistry repairing materials. In the preparation method, monomer bonds are connected to a dentistry resin-based material, so as to endow antibiosis property to the resin-based material. The structure general formula of the cross-linked polyquaternary ammonium salt type antibiosis monomer is shown in the specification. The preparation method comprises the following steps: 1, adding a solvent in tertiary amine substance, and adding halohydrocarbon substance for reflux reaction so as to obtain a product A, adding acyl chloride for reflux reaction by using toluene, benzene, dichloromethane or tetrahydrofuran so as to obtain quaternary ammonium salt B, and purifying the quaternary ammonium salt B; and 2, adding the acyl chloride and tertiary amine substancem by using the toluene, benzene, dichloromethane or tetrahydrofuran as the solvent, adding triethylamine as auxiliary, reacting to obtain the tertiary amine containing C=C, the tertiary amine takes acetone, metjylene dichloride and acetonitrile as the solvents, adding the halohydrocarbon for reflux reaction, and then purifying the quaternary ammonium salt monomer. In the invention, reaction steps are simple, the purity of the monomer is high, and the monomer has better compatibility and higher safety as compared with the common dentistry repairing resin monomer.

Description

technical field [0001] The invention belongs to the field of combination of macromolecular materials and biomedicine, in particular to a new type of cross-linkable polymeric quaternary ammonium salt type antibacterial monomer and its application in dental resin-based restoration materials. Background technique [0002] Quaternary ammonium antibacterial agents are a class of organic antibacterial agents that have been studied more. Compared with other antibacterial agents, quaternary ammonium salts have broad-spectrum antibacterial properties, low toxicity, stable performance, low corrosion, and long-term biological effects. is widely used. However, there are few reports on the application of quaternary ammonium salts in the study of oral biomaterials. [0003] Caries is a disease in which the hard tissue of the tooth body is chronically and progressively destroyed under the influence of various factors mainly including bacteria. The threat of harmful microorganisms in the ...

AI Technical Summary

Problems solved by technology

[0005] (1) Add organic antibacterial agents directly. This type of antibacterial agent has the advantages of fast onset of action, high antibacterial efficacy, and easy dispersion and mixing, but there are generally two disadvantages: first, its release kinetics show that within the first few days , the antibacterial agent is released in a large amount in the form of "burst release effect", and it is difficult to achieve long-term release of antibacterial ingredients; secondly, the mechanical properties of the material are significantly reduced after adding the antibacterial agent

[0006] (2) Wrap inorganic antibacterial agents. Inorganic antibacterial materials have the advantages of broad antibacterial spectrum, low toxicity, no drug resistance, and good chemical stability. However, silver is easy to vulcanize or oxidize, has poor light stability, and is easy to change color, so it is not suitable for shallow water. color materials, and the cost is higher

Therefore, there may be a small amount of antibacterial monomers that do not participate in the copolymerization reaction and are not bonded into the crosslinking system

Dental restoration materials will be used in the oral cavity for a long time, and the dissolution of unreacted monomers caused by long-term immersion will bring potential safety hazards to actual clinical applications.

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