Nasosinusitis soft capsule pharmaceutical preparation and preparation method thereof
A soft capsule and biyuan technology, applied in the field of traditional Chinese medicine, can solve the problems of difficult disintegration and many missed pills, and achieve the effects of preserving active ingredients, fast extraction and high efficiency.
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Embodiment 1
[0039] 1) Extract volatile oil
[0040] The parameters of supercritical carbon dioxide extraction of volatile oil are as follows: crush 93.75 kg of dried magnolia, 31.25 kg of honeysuckle, and 31.25 kg of wild chrysanthemum into 40 meshes, mix them and put them into a supercritical carbon dioxide extraction kettle in batches, adjust the temperature of the extraction kettle to 50°C, and the pressure 25MPa; the temperature of the separation tank is 15°C, and the pressure is 8MPa; the flow rate of carbon dioxide gas in the pipeline is adjusted to 20±5Kg / h for volatile oil extraction. The extraction time is 2.5 hours. Under this condition, the volatile oil is about 480g, and the yield is 3.1%, which is higher than the general steam distillation and hot water reflux method.
[0041] 2) Preparation of Biyuan Soft Capsules
[0042] The method for preparing Biyuan soft capsule according to claim 1, may further comprise the steps:
[0043] (1) Preparation of contents
[0044] 1. The...
Embodiment 2
[0059] 1) Extract volatile oil
[0060] The parameters of supercritical carbon dioxide extraction of volatile oil are as follows: crush 75kg of dried magnolia, 25kg of honeysuckle, and 25kg of wild chrysanthemum to 20 meshes, mix them and put them into a supercritical carbon dioxide extraction kettle in batches, adjust the temperature of the extraction kettle to 35°C, and the pressure to 30MPa; The temperature of the kettle is 20°C, and the pressure is 6MPa; the flow rate of carbon dioxide gas in the pipeline is adjusted to 25±5Kg / h, and the volatile oil is extracted. The extraction time was 2 hours. Under this condition, the volatile oil was about 377g, and the yield was 3.0%.
[0061] 2) Preparation of Biyuan Soft Capsules
[0062] (1) Preparation of content
[0063] ① Mix about 377g of the volatile oil extracted from magnolia, honeysuckle, and wild chrysanthemum with 2kg of safflower seed oil, and mix well;
[0064] ② Add 1 kg of beeswax to 8 kg of safflower oil, heat to...
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