Pharmaceutical composition for preventing dysbiosis associated with enteral administration of antibiotics

Abstract

In the first variant, the pharmaceutical composition comprises antibiotic and prebiotic in the form of oligosaccharide of a group comprising fructooligosaccharides, galactooligosaccharides, maltooligosaccharides and isomaltooligosaccharides the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic particle size ranges from 20 to 200 mkm and the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. In the second variant, the pharmaceutical composition comprises antibiotic which is in the form of a powder with the particle size ranging from 20 t0 200 mkm and is selected form a group consisting of beta-lactams, including the combination thereof with bacterial betalactamase inhibitors, azalides, fluoroquinalones, amphenicols, glycopeptides, ansamycins, nitrofurans, phosphonic acid derivatives, cycloserine and trimetoprim. The prebiotic is in the form of a powder oligosaccharide, the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. The above-mentioned compositions are used for preventing intestinal dysbiosis during antibiotic therapy and are perorally administered. The inventive composition produces a stimulating effect on intestinal lactobacilli and bifidobacteria simultaneously inhibiting the growth and proliferation of extraneous or pathogenic microflora.

Description

technical field [0001] This group of inventions relates to medicine, ie pharmacy and the development of compositions in pharmaceutical form, including antibiotics and prebiotics, for modulating the composition of the microbial flora in the intestinal tract during antibiotic therapy. Background technique [0002] Therapeutic effects of broad-spectrum antibiotics are often accompanied by gastrointestinal disturbances, which are associated with side effects of the antibiotics on the microflora in the large intestine. Antibiotics have a strong negative effect on the ammonium ion permeability of the biological cell membranes of the large intestine. Thus, antibiotics suppress not only pathogenic bacteria but also beneficial microbial flora in the digestive tract, leading to disturbances in homeostasis and promoting the development of dysbiosis and allergies. Disturbances in the balance of the gut microbiota lead in many cases to disturbances in the immune system and activation of...

AI Technical Summary

Problems solved by technology

Moreover, said compositions are characterized by complex production processes and insufficient potency in application

[0012] The disadvantages of this composition are mainly due to the high degree of polymerization and low purity of fructans hindering the process of fermentation of oligosaccharides by lactobacilli and bifidobacteria and the necessity to use a large amount of prebiotics in the composition