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Deamination new process by alkaline hydrolysis of nitrile compounds

A compound and nitrile technology, which is applied in the field of alkaline deamination of nitrile compounds, can solve the problems of difficult recovery of ammonia condensation, high power consumption, high water consumption, and low concentration of ammonia water, so as to reduce equipment investment, improve recovery rate, and improve deamination The effect of ammonia efficiency

Active Publication Date: 2011-03-30
BEIJING ZIGUANG YINGLI CHEM TECH CO LTD
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Decompression deamination not only needs to be equipped with a vacuum system, but also consumes a lot of electricity and water. It is also difficult to condense and recover ammonia, which is one of the more troublesome links in industrial production.
Since the solubility of ammonia in water is more affected by temperature than pressure, to reduce the content of ammonia in the deamination solution, deamination must be carried out at a higher temperature. The boiling point is low, and a large amount of water is easily vaporized and brought out, resulting in a low concentration of ammonia water, poor recovery rate of ammonia, and high energy consumption.

Method used

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  • Deamination new process by alkaline hydrolysis of nitrile compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 4180kg of aminoacetonitrile aqueous solution (containing 1120kg of aminoacetonitrile) was preheated to 60°C through a heat exchanger, and 1895L (specific gravity 1.32) of 32% liquid caustic soda was pumped into the rapid mixing alkaline hydrolysis reactor through a metering pump. The rapid mixing alkaline hydrolysis reactor produces amino acetic acid and releases ammonia during the reaction process. The reaction is an exothermic reaction. Under slight negative pressure, the ammonia produced by the reaction is carried away with water, and at the same time the heat generated by the reaction is taken away. The temperature of the hot water in the jacket is adjusted to maintain the temperature of the reaction material at about 75°C. , The residence time of each batch of aminoacetonitrile hydrolysate in the reactor is 35 minutes. After measuring in the measuring tank, 480L of ammonia water is produced every 35 minutes. The hydrolysis solution and ammonia water were sampled an...

Embodiment 2

[0026] 3960kg of anilinoacetonitrile aqueous solution (containing 1320kg of anilinoacetonitrile) is heated to 50°C and 1420L (specific gravity 1.32) 32% liquid caustic soda is pumped into the hydrolysis reactor through a metering pump respectively. During the reaction, sodium anilinoacetate is formed and ammonia is released. The reaction is exothermic. Under slight negative pressure, the ammonia produced by the reaction entrains water and is taken away, while taking away the heat generated by the reaction. The temperature of the jacketed hot water is adjusted to maintain the temperature of the reaction material at about 65°C. , The residence time of each batch of anilinoacetonitrile hydrolysate in the reactor is 30 minutes. After measuring by the measuring tank, 315L of ammonia water is produced every 30 minutes. The hydrolysis liquid and ammonia water were sampled and analyzed respectively. Among them, the specific gravity of the ammonia water was 0.92, the concentration was ...

Embodiment 3

[0031] Add 3000L of process water to the 5000L dissolving kettle, turn on steam to raise the temperature to 85°C, add 1630kg (15.78kmol) of 92% iminodiacetonitrile solid with stirring, and the temperature in the kettle will be 72°C after dissolution. After 3510L of 30% liquid caustic soda is measured by a metering pump, it and the dissolved iminodiacetonitrile solution are respectively pumped into the rapid mixing alkaline hydrolysis reactor through the metering pump. In the rapid mixing alkaline hydrolysis reactor, through efficient mass transfer and heat transfer, the iminodiacetonitrile and sodium hydroxide in the material fully contact and react, and at the same time release ammonia. The alkaline hydrolysis reaction is an exothermic reaction. Under slight negative pressure, the ammonia produced by the reaction is carried away with water, and at the same time the heat generated by the reaction is taken away. The reaction temperature is maintained at about 70℃. The reactor siz...

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Abstract

The invention provides a new deamination process method for preparing amino acids by alkaline hydrolysis of nitrile compounds (such as aminoacetonitrile, anilinoacetonitrile, iminodiacetonitrile and the like). The method can control the reaction temperature by decompression control of deamination degree, realize continuous fast large-scale alkaline hydrolysis and realize fast and high-efficient complete removal of free ammonia. The method can greatly improve the removal rate of ammonia, the recovery rate of the ammonia and the product quality, reduce material consumption and energy consumption, reduce equipment investment and achieve the purposes of energy conservation and emission reduction.

Description

Technical field [0001] The invention relates to a new process for alkali hydrolysis and deamination of nitrile compounds. Background technique [0002] Alkaline hydrolysis, deamination and acidification of nitriles are important methods for the synthesis of carboxylic acids, especially amino acids, and one of the most important uses of hydrocyanic acid as intermediates in organic synthesis. Hydrocyanic acid reacts with formaldehyde to easily obtain hydroxyacetonitrile. Hydroxyacetonitrile reacts with ammonia or amine to easily obtain aminoacetonitrile, iminobisacetonitrile, anilinoacetonitrile, etc., which can be obtained after alkaline hydrolysis, deamination, acidification, crystallization and separation The corresponding amino acid. [0003] At present, the alkaline hydrolysis and deamination of nitrile are carried out under reduced pressure. Since nitriles are prone to substitution and polymerization reactions in the process of preparing carboxylic acid products by hydrolyzin...

Claims

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Application Information

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IPC IPC(8): C07C227/26C07C227/40C07C229/08C07C229/18C07C229/16
Inventor 崔建斌廖翠莺李星黄仁才喻宏贵尹应武
Owner BEIJING ZIGUANG YINGLI CHEM TECH CO LTD
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