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Method for extracting tripterygium glycosides, and product and inclusion compound and medicinal composition thereof

A technology of tripterygium glycosides and extraction methods, which is applied in the fields of extraction methods of tripterygium glycosides and the obtained products and their clathrates and pharmaceutical compositions, and can solve the problems of complex components of the extract, high labor intensity, and complicated operations, etc. Achieve the effects of improving bioavailability, reducing energy consumption, and reducing production costs

Active Publication Date: 2011-03-30
上海复旦复华药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The technical problem to be solved by the present invention is to overcome the poor selectivity of the existing tripterygium glycosides extraction method, the obtained extract has complex components, high toxicity, low content of active ingredients, and further separation and purification is required for preparation production. Defects; or during the extraction, large amounts of water and organic solvents are used, a lot of waste, serious environmental pollution, and large energy consumption; or there are many steps in the extraction process, complicated operations, time-consuming and labor-intensive, and other defects. Provided is a method for extracting tripterygium glycosides, the obtained product, its clathrate and pharmaceutical composition

Method used

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  • Method for extracting tripterygium glycosides, and product and inclusion compound and medicinal composition thereof
  • Method for extracting tripterygium glycosides, and product and inclusion compound and medicinal composition thereof
  • Method for extracting tripterygium glycosides, and product and inclusion compound and medicinal composition thereof

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Experimental program
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Effect test

Embodiment 1

[0045] Get dry, mildew-free, peeled Tripterygium wilfordii root coarse powder (10kg), mix evenly with 200 mesh chromatography silica gel (15kg) of 1.5 times of weight, pulverize, make it all cross 200 mesh sieves. The homogeneous mixture of the pulverization of Tripterygium wilfordii and adsorbent is packed into a chromatographic column (inner diameter × length is a stainless steel column of 300mm × 1500mm) filled with equal weight chromatographic silica gel (25kg), compacted, and 75kg of medicinal chloroform ( (approximately more than 20cm of solid material) impregnated for 24 hours, and then eluted with chloroform until the eluent was basically colorless, and checked by silica gel G thin plate chromatography, using a mixture of cyclohexane and acetone with a volume ratio of 5:3 as the developer , after unfolding and drying, after confirming that the blue fluorescent spots at the front extension have disappeared, elute with a chloroform solution containing 5% ethanol mass perc...

Embodiment 2

[0047] Get dry, mildew-free, peeled tripterygium root coarse powder (10kg), mix evenly with 1.5 times the weight of chromatographic silica gel (15kg), pulverize, and make it all pass through a 200-mesh sieve. The pulverized homogeneous mixture of Tripterygium wilfordii and adsorbent is packed into a chromatographic column (300 × 1500mm stainless steel column) filled with equal weight chromatographic silica gel (25kg), compacted, and 75kg of medicinal chloroform (about 20cm above the solid material) is added. ) for 24 hours, and then eluted with chloroform until the eluent is basically colorless, checked by silica gel G thin plate chromatography, using a mixture of cyclohexane and acetone with a volume ratio of 5:3 as the developer, and dried in the air after development. After confirming the disappearance of the blue fluorescent spots at the front extension, elute with a chloroform solution containing 5% ethanol by mass until the eluate is colorless, and collect and combine the...

Embodiment 3

[0050] Take by weighing the Tripterygium wilfordii polyglycoside 50g of embodiment 1 gained, and auxiliary material starch 98.2g, dextrin 5g, calcium hydrogen phosphate 250g, low-substituted hydroxypropyl cellulose 40g, get the starch of 13.2g and make 8% starch slurry altogether 165g, Mix with other substances, shake and granulate with 18 mesh, put it in an oven, dry at 60°C, granulate through 18 mesh, then add 4.4g of magnesium stearate, mix for 10 minutes, and calculate as each tablet contains 10mg tripterygium glycosides Tablet weight, with a 5.5mm round shallow punched tablet. The average tablet weight is 0.088-0.089g / tablet, and the content of triptolide A is 0.82mg / g.

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Abstract

The invention discloses a method for extracting tripterygium glycosides, and a product and an inclusion compound and a medicinal composition thereof. The method for extracting the tripterygium glycosides comprises the following steps of: loading a uniform mixture obtained by crushing common threewingnut root and an adsorbent to a silicagel column, adding chloroform for impregnating, eluting by using the chloroform until eluent is colorless, eluting by using mixed liquor of ethanol and the chloroform in a mass ratio of 4.5:95.5-10:90, and collecting ethanol and chloroform eluent. In the extraction method, the steps are simple, the using amount of an organic solvent is small, waste water is hardly generated, the organic solvent can be basically recycled, pollution is reduced, energy consumption is greatly reduced, and production cost is reduced; and the prepared tripterygium glycosides have high active ingredient content, particularly high wilforlide A content, and meet the national standard; a medicinal preparation can be directly prepared without the separation and purification of the tripterygium glycosides; and tripterygium glycoside tablets have high dissolution rate and bioavailability.

Description

technical field [0001] The invention relates to a method for extracting tripterygium wilfordii polyglycoside and the obtained product, its clathrate and pharmaceutical composition. Background technique [0002] Tripterygium wilfordii Hook f. According to "Chinese Medicine Plants", it is the whole plant of Tripterygium wilfordii Hook f. in the Euonymus family. There are three main types in my country, including Tripterygium wilfordii Hook f., Kunming Begonia (Tripterygium hypoglaucum Hutch) and Northeast Tripterygium (Tripterygium regelii Spraque et Tak.), the main production areas are Fujian, Zhejiang, Jiangsu, Anhui, Hunan and other places; the nature and flavor are bitter, pungent, cold, very poisonous, and return to the liver and kidney channels; Its medicinal part is the root xylem of the split layer bark, which has the functions of expelling wind and dampness, promoting blood circulation and dredging collaterals, reducing swelling and pain, killing insects and detoxifying...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K47/48A61P29/00A61P37/06A61P19/02A61P19/04A61P13/12A61P1/16A61K47/69
Inventor 朱泽龙任昉
Owner 上海复旦复华药业有限公司
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