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Medical ultrasonic probe sterilizing gel and preparation method thereof

A technology of disinfecting gel and ultrasonic probe, applied in botany equipment and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems affecting the transparency, safety and stability of gel products , Inability to achieve quick-acting bactericidal effect, poor water solubility of disinfectant, etc., to achieve long-lasting bactericidal effect, less foam, and excellent bactericidal performance

Inactive Publication Date: 2011-03-23
北京财之源科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Including the above-mentioned prior art disclosures, most of the couplers currently claiming to have disinfection and sterilization functions are mostly gel matrix cross-linked polyacrylic resin, sodium alginate and disinfectant triclosan, chlorhexidine acetate or monochlorohydrin. Chain quaternary ammonium salt fungicides such as benzalkonium chloride are compatible to provide sterilization and disinfection functions, but triclosan hydroxydiphenyl ether and chlorhexidine acetate are low-efficiency disinfectants in these disinfectants, and they need to be used in combination with ethanol to enhance the sterilization performance , the experimental results show that when used alone, a lower dose cannot achieve a good quick-acting bactericidal effect
The reason is that the use of ethanol is obviously limited due to the contact of the coupling agent with human skin and organs; on the other hand, these disinfectants have poor water solubility and have a strong Incompatibility, higher dosage will affect the transparency, safety and stability of the gel product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Weigh 1-2g of gel matrix hydroxypropylmethylcellulose or hydroxyethylcellulose according to the weight percentage of the formula, add 40-50ml of distilled water heated to 70-80°C, stir to dissolve;

[0027]2) Weigh 0.2-0.4g of chlorhexidine acetate, dissolve in 15-20ml of distilled water, heat to make it completely dissolved, slowly add to the solution prepared in step 1, and continue stirring;

[0028] 3. Add 10ml of double-chain quaternary ammonium salt fungicide didecyldimethylammonium chloride aqueous solution with an absorption content of 1-2% (V / V) into the above solution, and stir to mix;

[0029] 4. Add 1ml~2ml propylene glycol to the above solution, and continue to stir and mix well.

[0030] 5. Make up distilled water to 100ml, slowly add a few drops of 1mol / L sodium hydroxide solution in the stirring state, and adjust the pH value to 7.0-8.0.

[0031] 6. Let it stand for 24 hours or overnight, until the air bubbles are eliminated, and then you can get a s...

Embodiment 2

[0041] 1. Weigh 15g of the gel base poloxamer P407 according to the weight percentage of the formula, add 50-60ml of distilled water cooled to 5-10°C, stir to fully dissolve it, then place it at room temperature to return to normal temperature.

[0042] 2. Weigh 0.2-0.4g of chlorhexidine acetate, dissolve it in 15-20ml of distilled water, heat it to dissolve completely, slowly add it into the solution prepared in step 1, and continue stirring.

[0043] 3. Add 10 ml of an aqueous solution of double-chain quaternary ammonium bis(dodecyldimethyl)ethylene diammonium ammonium bromide with an absorption content of 1-2% (v / v) into the above solution, and stir to mix.

[0044] 4. Add 0.5ml~1ml propylene glycol to the above solution, and continue to stir and mix.

[0045] 5. Make up distilled water to 100ml, slowly add a few drops of 1mol / L sodium hydroxide solution in the stirring state, and adjust the pH value to 7.0-8.0.

[0046] 6. Let it stand for 24 hours or overnight, until the...

Embodiment 3

[0049] Same as raw material and preparation process of embodiment 1, but make the content of chlorhexidine acetate be 0.2% (g / ml) in the gel product, and the content of double-chain quaternary ammonium salt bactericide is 0.1% (v / v) .

[0050] The properties and effects of the gel are similar to the examples.

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Abstract

The invention provides a medical ultrasonic probe stelrizing gel and a preparation method thereof. The gel comprises the following components of 0.5-5 percent (w / v) of non-ionic cellulose material or 5-20 percent (w / v) of poloxamer, 0.1-0.5 percent (w / v) of chlorhexidine acetate, 0.1-0.5 percent (w / v) of double-chain quaternary ammonium salt sterilizing agent, 0.5-2 percent (v / v) of wetting agent and the balance of water. The sterilizing agent has the function of sterilizing and disinfecting a medical ultrasonic probe and the skin; and a soluble medical ultrasonic probe sterilizing gel with better acoustical property, safety and stability can be used as a coupling agent, can realize high-efficiency sterilization within short time and concurrent disinfection on the ultrasonic probe, and achieves the purpose of reducing cross infection risk caused possibly in the clinical ultrasonic detection process.

Description

technical field [0001] The invention relates to a gel product with disinfection and sterilization functions for medical ultrasonic probes and human skin and a preparation method thereof. Background technique [0002] A number of investigations and studies have shown that with the widespread application of clinical ultrasound examinations, medical ultrasound probes are frequently in contact with different groups of people, including healthy checkups, infectious disease patients, skin disease patients, infants, pregnant women, etc. If they are not timely and regularly disinfected In clinical examination, probes often carry a variety of common nosocomial infection microorganisms, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, multidrug-resistant bacteria MRSA, MRSE, etc., causing iatrogenic cross-infection. The "Disinfection Management Measures" promulgated by the Ministry of Health of my country stipulates that all instruments and supplies that touc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A01N47/44A01N33/12A61K31/155A61K31/14A61K47/38A61K47/34A01P1/00A61P31/04A61P31/10A61K47/10
Inventor 韩艳霞魏秋华姚楚水王长德
Owner 北京财之源科技有限公司
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