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Mineral absorption accelerator and iron deficiency anemia improver or food composition

A technology of absorption enhancers and minerals, applied in the direction of drug combination, food science, active ingredients of heterocyclic compounds, etc., can solve problems such as unimproved side effects, side effects of digestive organs, etc.

Active Publication Date: 2011-03-02
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, various pharmaceutical preparations have been invented as iron compound pharmaceutical preparations for the prevention or treatment of anemia, but side effects of digestive organs caused by iron such as loss of appetite, nausea, vomiting, abdominal pain, Constipation, diarrhea, etc.
[0005] Hitherto, it was found that the recovery of hemoglobin was promoted when iron products and proline were simultaneously administered to anemia model rats (J. Nutr. Sci. Vitaminol., 49, 7-12, 2003), and the use of yeast cell wall polysaccharides has been reported. method (JP-A-2002-255832), a method of simultaneously using a set of isoleucine, valine, leucine and arginine, and an iron product (JP-A-2008-50277), etc., these methods Has the effect of improving iron absorption, but does not improve the above-mentioned side effects

Method used

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  • Mineral absorption accelerator and iron deficiency anemia improver or food composition
  • Mineral absorption accelerator and iron deficiency anemia improver or food composition
  • Mineral absorption accelerator and iron deficiency anemia improver or food composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Root and stem parts of Salacia reticulata and Salacia oblonga were pulverized and subjected to a hot water extraction process, and the liquid thus obtained was spray-dried to obtain Salacia extract powder.

[0051] Also, 300 g of dry mulberry leaf powder was extracted by adding 1 L of 25% ethanol, and the filtrate was dried by removing the solvent under reduced pressure, thereby obtaining a mulberry leaf extract.

[0052] The dried guava leaf powder was extracted by adding hot water at 95° C., and the filtrate was dried by removing the solvent under reduced pressure, thereby obtaining a guava leaf extract.

[0053] Powders having the formulations shown in Table 1 were prepared using the extract powder thus obtained, and the sucrase IC50 values ​​thereof were measured by the method described in [Test method 1].

[0054] In addition, tablets of Sample 1 to Sample 13 were prepared by forming the formulation powder of Table 1 into tablets.

[0055] Table 1: α-Glucosidase I...

Embodiment 2

[0065] Salacinol was isolated from the Salacia extract powder prepared in Example 1 by the method described by Yoshikawa in Bioorganic & Medicinal Chemistry, 10 (2002) 1547-1554. Using this substance and the alpha-glucosidase inhibitors voglibose and acarbose, the following assays were performed.

[0066] SD rats (male) aged 4 weeks after birth were bred in advance for 1 week, and then randomly divided into a control group and six sample intake groups, each consisting of 6 animals, based on body weight. In the rats of the salacinol-administered group, a 0.1% salacinol aqueous solution was orally administered at a dose of 2.0 g / day / unit weight of the rat. In the rats in the voglibose-administered group, 0.4% voglibose aqueous solution was orally administered at a dose of 2.0 g / day / unit weight of rats. In the rats in the acarbose-administered group, 0.4% acarbose aqueous solution was orally administered at a dose of 2.0 g / day / unit weight of rats. In the rats of the Salacia ext...

Embodiment 3

[0081] Tablets were prepared using Salacia extract powder.

[0082] By preparing tablets using the formulation shown in Table 6, the supplements to which the shellac coating was applied were prepared.

[0083] Table 6: Examples of tablet formulations using extract powders of the invention

[0084] Raw material name

[0085] The effects shown in Example 1 were obtained by ingesting tablets of this formulation. In addition, the volunteers who ingested it reported that "the physical condition has become lighter" and "the feeling of fatigue has been reduced".

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PUM

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Abstract

A mineral absorption accelerator, and an anemia improving agent, food and drink or food and drink material containing the mineral absorption accelerator are provided, the mineral absorption accelerator including: an a-glucosidase inhibitory component.

Description

technical field [0001] The present invention relates to a mineral absorption enhancer, an iron deficiency anemia improver, or a food composition comprising a component having an α-glucosidase inhibitory action or a pulverized product or extract of a plant of the genus Salacia. Background technique [0002] In recent years, the food situation of the Japanese has improved to such a level that the average intake of almost all nutrients has reached the necessary nutritional quantity, but the intake of minerals such as iron, calcium, zinc, copper has not reached the necessary level (National Nutrition Survey, 2001). [0003] Especially in the case of iron, when insufficient intake thereof is sustained, iron deficiency anemia may be caused due to underlying iron deficiency without symptoms of anemia. It is said that this iron deficiency anemia usually occurs mainly in adult women, and about half of adult women are affected by underlying iron deficiency or iron deficiency anemia. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A23L1/30A61K31/10A61K31/133A61K31/381A61K31/445A61K31/7034A61K36/00A61P3/02A61P7/06A61P43/00C12N9/34C12N9/99
CPCA61K36/48A61K36/37A61K36/82A61K36/61A61K36/45A23L1/30A23L1/3002A23L33/10A23L33/105A61P3/00A61P3/02A61P43/00A61P7/06A61K2300/00
Inventor 植田文教
Owner FUJIFILM CORP
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