Flexible nano realgar liposome as well as preparation method and application thereof

Abstract

The invention discloses a flexible nano realgar liposome as well as a preparation method and application thereof, which is used for solving the problems of unabiding medicine potency, weak targeting performance and the like in medicines for treating cervical carcinoma in the prior art. The flexible nano realgar liposome contains the main drug of realgar and the auxiliary materials of deoxysodium cholate, natural soya lecithin, cholesterol, vitamin E and the like. In the method of the invention, the realgar is processed by using a nano Chinese medicine technique, thereby preparing the realgar into membranous flexible nano realgar liposome. The flexible nano liposome is a targeting medicine carrier with high self deformation, can penetrate through skin pore canals which are multiple times smaller than the liposome, has the characteristics of lipotropy, hydrophilicity, high permeation efficiency, high flexibility, high compatibility and the like, and has great potential in the field of targeting administration therapy for cervical carcinoma.

Description

Technical field [0001] The present invention relates to the technical field of a medicine and its preparation method and application, in particular to a flexible nano-realgar liposome and its preparation method and application. The product is suitable for cervix and other solid malignant entities capable of transdermal or mucosal administration. Tumor. Background technique [0002] The incidence of cervical cancer ranks first among malignant tumors of the female genital tract. The latest global data show that among women around the world, the number of new cases each year is 46,000, and 80% of the cases occur in developing countries. my country has 131,500 new cases each year, accounting for about 28.8% of the world’s new cases of cervical cancer. After decades of extensive gynecological surveys, the incidence and mortality of cervical cancer have been reduced by nearly 68%, but the prevalence of cervical cancer still ranks first among women in my country, and the incidence of ...

AI Technical Summary

Problems solved by technology

But ① there is currently no research to track and mark the anti-tumor molecular components of realgar in vitro and in vivo; ② realgar is sensitive to temperature and light, has unstable properties, and is easily converted into arsenic (that is, produced by As 4 S 4 Convert to As 2 o 3 ); ③As 4 S 4 and As 2 o 3 The anti-tumor and toxicity mechanisms are the same. As binds to the sulfhydryl group of the enzyme protein, interferes with the activity of sulfhydryl enzymes, affects cell biological metabolism, stress repair, oncogene expression, induces cancer cell apoptosis, and inhibits cancer cell cycle progression, etc. ; ④As 2+ Extremely difficult to dissolve in water, poor absorption in the gastrointestinal tract, low bioavailability, difficult to achieve anti-tumor effect; ⑤As 2 o 3 Compared with As 4 S 4 More toxic, which is the necessary basis for arsenic preparations to inhibit vigorous cancer cells in small doses and in a short-term manner

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