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Szechuan lovage rhizome total phthalide extract

A technology for total phthalides and extracts, applied in the field of total phthalides of Chuanxiong Rhizoma Rhizoma Chuanxiong and its preparation, can solve the problems of undefined technical quality standards, strict standards for raw material selection, and large differences in pharmacological activity. , to achieve significant pharmacological activity, significant curative effect, and low toxicity

Active Publication Date: 2011-02-23
广东泰康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] ① Due to the wide range of production of Chuanxiong, the phthalide compounds contained in it are quite different, resulting in a large difference in its pharmacological activity, or even ineffectiveness, and no strict standards have been established for the selection of raw materials;
[0008] ②The technical quality standard that the total phthalide extract of Chuanxiong Rhizoma Rhizoma Rhizoma Chuanxiong should have for the treatment of ischemic stroke has not been clearly defined; a wide range of changes in active ingredients will inevitably lead to changes in curative effect and uncertainty in safety
[0011] Although these existing Chuanxiong extracts have a certain curative effect, they all have the problems of insignificant or unstable clinical curative effect and poor safety.

Method used

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  • Szechuan lovage rhizome total phthalide extract
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  • Szechuan lovage rhizome total phthalide extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]After the Rhizoma Chuanxiong medicinal material was removed from impurities, washed and dried, 100kg was taken and pulverized into fine powder. The Rhizoma Chuanxiong fine powder was measured by high-performance liquid chromatography, and the main component ligustilide (ligustilide) accounted for 1.61% of the original medicinal material; n-butyl- The total content of 4,5-dihydrophthalide (Senkyunolide A) and neocnidilide (neocnidilide) is measured by the external standard of n-butyl-4,5-dihydrophthalide (Senkyunolide A), accounting for 0.64% of the original medicinal material; The ratio of ligustilide to the sum of n-butyl-4,5-dihydrophthalide (Senkyunolide A) and neocnidilide (neocnidilide) is 2.5:1. Conform to the relevant requirements of feeding. Wet the Rhizoma Chuanxiong fine powder with 100kg of 85% ethanol, then evenly add it into the percolation tank, add 2 times the weight of 200kg of ethanol at the same concentration, soak for 1 hour, and drip at a rate of 1.5m...

Embodiment 2

[0037] After removing impurities, washing and drying the Rhizoma Chuanxiong medicinal material, take 100kg and pulverize it into a fine powder. The Ligusticum Rhizoma Chuanxiong fine powder is determined by high performance liquid chromatography, and the main component ligustilide accounts for 1.35% of the original medicinal material; n-butyl-4,5 - The total content of dihydrophthalide and neocnilide is measured by n-butyl-4,5-dihydrophthalide external standard, accounting for 0.56% of the original medicinal material; ligustilide and n-butyl-4,5-dihydrophthalide The ratio of the sum of hydrophthalide and neocnilide is 2.41:1. Conform to the relevant requirements of feeding. Wet the Rhizoma Chuanxiong fine powder with 100kg of 90% ethanol, which is 1 times the weight, and then evenly add it to the percolation tank, then add 2 times the weight, 200kg, of the same concentration of ethanol, soak for 1 hour, and drip at a rate of 1.5ml / kg min The seepage liquid is collected, and t...

Embodiment 3

[0039] After removing impurities, washing and drying the Rhizoma Chuanxiong medicinal material, take 100kg and grind it into a fine powder. The fine powder of Rhizoma Chuanxiong is determined by high performance liquid chromatography, and the main component ligustilide accounts for 0.28% of the original medicinal material; n-butyl-4,5 - The total content of dihydrophthalide and neocnilide is measured by n-butyl-4,5-dihydrophthalide external standard, accounting for 0.12% of the original medicinal material; ligustilide and n-butyl-4,5-dihydrophthalide The ratio of the sum of hydrophthalide and neocnilide is 2.33:1. Does not meet the relevant requirements for feeding. Wet the Rhizoma Chuanxiong fine powder with 100kg of 85% ethanol, then evenly add it into the percolation tank, add 2 times the weight of 200kg of ethanol at the same concentration, soak for 1 hour, and drip at a rate of 1.5ml / kg min The seepage liquid is collected, and the seepage liquid is concentrated under red...

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Abstract

The invention relates to a szechuan lovage rhizome total phthalide extract and a preparation method thereof. The extract comprises the following main components of: ligustilide, n-butyl-4,5-dyhydrophthalide and new cnidium monnier lactone, wherein the ligustilide accounts for 20 to 50 percent of the total phthalide; the n-butyl-4,5-dyhydrophthalide and the new cnidium monnier lactone account for 10 to 40 percent of the total phthalide; the ratio of the ligustilide to the sum of the n-butyl-4,5-dyhydrophthalide and the new cnidium monnier lactone is 1.5:1-3.5:1; and fatty acid accounts for 20 to 40 percent of the total composition. The szechuan lovage rhizome total phthalide extract has high quality reliability, stable pharmacological activity and repeatability of clinic effect.

Description

technical field [0001] The invention relates to a total phthalide extract of Rhizoma Chuanxiong with a specific ratio and a preparation method thereof Background technique [0002] The traditional Chinese medicine Chuanxiong is the dried rhizome of Chuanxiong, a plant belonging to the genus Artemisia in the Umbelliferae family. It is widely used clinically to treat headache, chest and rib pain, amenorrhea abdominal pain, bruises, coronary heart disease, cerebrovascular disease, etc. The medicinal active ingredient of Rhizoma Chuanxiong is mainly total phthalide of Rhizoma Chuanxiong, which is composed of ligustilide, n-butyl-4,5-dihydrophthalide and its derivative polymers, including: ligustilide, n-butyl Base-4,5-dihydrophthalide, butenylphthalide, neocnilide, 3-butylphthalide, cnidactone, 4-hydroxy-3-butylphthalide, 3-butene Base-7-hydroxyphthalide, cis-6,7-dihydroxyligustilide, trans-6,7-dihydroxyligustilide, ligusticol, 3-butyl-3,6,7-trihydroxy - phthalide dimers such...

Claims

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Application Information

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IPC IPC(8): A61P9/10C07D307/88A61K36/236
Inventor 刘俊魏玉平
Owner 广东泰康制药有限公司
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